Management of CAH involves not only replacing cortisol deficiency but also managing elevated adrenal androgen levels, which are responsible for the detrimental symptoms associated with hyperandrogenism, such as virilization in females and abnormalities in growth leading to short stature and early puberty. Current treatment guidelines recommend a target daily hydrocortisone dose of ≤25 mg (or equivalent dose of prednisone, prednisolone, or dexamethasone) in adult (fully grown) patients with CAH. However, hydrocortisone doses of >25 mg are often necessary to lower adrenal androgens in CAH. Thus, physicians treating CAH patients typically face a difficult dilemma of trying to manage the androgen excess while also trying to avoid the well-known consequences of chronic glucocorticoid overexposure.
The post hoc analyses examined total glucocorticoid daily dose and
"These analyses help demonstrate the impact of modified-release hydrocortisone as a potential treatment for adults with congenital adrenal hyperplasia by delivering cortisol in a manner that matches the body's natural circadian rhythm," said Eiry W. Roberts, M.D., Chief Medical Officer at
About Modified-Release Hydrocortisone
About Congenital Adrenal Hyperplasia
Congenital adrenal hyperplasia is a group of rare genetic disorders in which a gene mutation results in the deficiency of one of the enzymes that is involved in the production of adrenal hormones. The most common mutation is to the gene encoding the adrenal enzyme 21-hydroxylase, which is responsible for the synthesis of cortisol in the adrenal glands. The disorder is associated with low cortisol levels that can be life-threatening and excess adrenal androgen that can lead to virilization in females and abnormalities in growth leading to short stature and early puberty.
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