Entity Central Index Key Document And Entity Information. Document And Entity Information [Abstract] Document Type Document Type Amendment Flag Amendment Flag Document Period End Date Document Period End Date Document Fiscal Year Focus Document Fiscal Year Focus Document Fiscal Period Focus Document Fiscal Period Focus Trading Symbol Trading Symbol Entity Registrant Name Entity Registrant Name Entity Central Index Key Current Fiscal Year End Date Current Fiscal Year End Date Entity Well-known Seasoned Issuer Entity Well Known Seasoned Issuer Entity Current Reporting Status Entity Current Reporting Status Entity Voluntary Filers Entity Voluntary Filers Entity Filer Category Entity Filer Category Entity Small Business Entity Small Business Entity Emerging Growth Company Entity Emerging Growth Company Entity Shell Company Entity Shell Company Entity Common Stock, Shares Outstanding Entity Common Stock Shares Outstanding Entity Public Float Entity Public Float The noncurrent portion of deferred gains on the sale of real estate. Statement Of Financial Position [Abstract] ASSETS Assets [Abstract] Current assets: Assets Current [Abstract] Cash and cash equivalents Cash And Cash Equivalents At Carrying Value Short-term investments, available-for-sale Available For Sale Securities Debt Securities Current Accounts receivable Accounts Receivable Net Current Inventory Inventory Net Other current assets Other Assets Current Total current assets Assets Current Property and equipment, net Property Plant And Equipment Net Long-term investments, available-for-sale Available For Sale Securities Debt Securities Noncurrent Restricted cash Restricted Cash And Cash Equivalents Noncurrent Total assets Assets LIABILITIES AND STOCKHOLDERS’ EQUITY Liabilities And Stockholders Equity [Abstract] Current liabilities: Liabilities Current [Abstract] Accounts payable and accrued liabilities Accounts Payable And Accrued Liabilities Current Other current liabilities Other Liabilities Current Total current liabilities Liabilities Current Deferred gain on sale of real estate Deferred Gain On Sale Of Real Estate Noncurrent Deferred revenue Deferred Revenue Noncurrent Deferred rent Deferred Rent Credit Noncurrent Convertible senior notes Convertible Debt Noncurrent Total liabilities Liabilities Commitments and contingencies Commitments And Contingencies Stockholders’ equity: Stockholders Equity [Abstract] Preferred stock, $0.001 par value; 5,000,000 shares authorized; no shares issued and outstanding Preferred Stock Value Common stock, $0.001 par value; 220,000,000 shares authorized; issued and outstanding shares were 90,797,087 and 88,793,903 at December 31, 2018 and 2017, respectively Common Stock Value Additional paid-in capital Additional Paid In Capital Common Stock Accumulated other comprehensive loss Accumulated Other Comprehensive Income Loss Net Of Tax Accumulated deficit Retained Earnings Accumulated Deficit Total stockholders’ equity Stockholders Equity Total liabilities and stockholders’ equity Liabilities And Stockholders Equity Preferred stock, par value Preferred Stock Par Or Stated Value Per Share Preferred stock, shares authorized Preferred Stock Shares Authorized Preferred stock, shares issued Preferred Stock Shares Issued Preferred stock, shares outstanding Preferred Stock Shares Outstanding Common stock, par value Common Stock Par Or Stated Value Per Share Common stock, shares authorized Common Stock Shares Authorized Common stock, shares issued Common Stock Shares Issued Common stock, shares outstanding Common Stock Shares Outstanding Investment income and other net. Income Statement [Abstract] Statement [Table] Statement [Table] Product and Service Product Or Service [Axis] Product and Service Products And Services [Domain] Product sales, net Product [Member] Collaboration revenue. Collaboration revenue Collaboration Revenue [Member] Statement [Line Items] Statement [Line Items] Revenues: Revenues [Abstract] Revenues Revenue From Contract With Customer Excluding Assessed Tax Operating expenses: Operating Expenses [Abstract] Cost of sales Cost Of Goods And Services Sold Type of Cost, Good or Service [Extensible List] Type Of Cost Good Or Service Extensible List Research and development Research And Development Expense Sales, general and administrative Selling General And Administrative Expense Total operating expenses Operating Expenses Income (loss) from operations Operating Income Loss Other (expense) income: Nonoperating Income Expense [Abstract] Interest expense Interest Expense Investment income and other, net Investment Income And Other Net Total other (expense) income Nonoperating Income Expense Income (loss) before provision for income taxes Income Loss From Continuing Operations Before Income Taxes Extraordinary Items Noncontrolling Interest Provision for income taxes Income Tax Expense Benefit Net income (loss) Net Income Loss Net income (loss) per share: Earnings Per Share [Abstract] Basic Earnings Per Share Basic Diluted Earnings Per Share Diluted Shares used in the calculation of net income (loss) per share: Weighted Average Number Of Shares Outstanding [Abstract] Weighted average common shares outstanding, basic Weighted Average Number Of Shares Outstanding Basic Weighted average common shares outstanding, diluted Weighted Average Number Of Diluted Shares Outstanding Other comprehensive income (loss): Other Comprehensive Income Loss Net Of Tax Period Increase Decrease [Abstract] Net income (loss) Unrealized (loss) gain on available-for-sale securities Other Comprehensive Income Unrealized Holding Gain Loss On Securities Arising During Period Net Of Tax Comprehensive income (loss) Comprehensive Income Net Of Tax Statement Of Stockholders Equity [Abstract] Equity Components Statement Equity Components [Axis] Equity Component Equity Component [Domain] Common Stock Common Stock [Member] Additional Paid in Capital Additional Paid In Capital [Member] Accumulated Other Comprehensive (Loss) Gain Accumulated Other Comprehensive Income [Member] Accumulated Deficit Retained Earnings [Member] Begining balance Begining balance (in shares) Shares Outstanding Unrealized gains (losses) on available for sale investments Share-based compensation expense Adjustments To Additional Paid In Capital Sharebased Compensation Requisite Service Period Recognition Value Issuance of common stock for vested restricted stock units Stock Issued During Period Value Share Based Compensation Issuance of common stock for vested restricted stock units (in shares) Stock Issued During Period Shares Share Based Compensation Issuance of common stock for stock option exercises Stock Issued During Period Value Stock Options Exercised Issuance of common stock for stock option exercises (in shares) Stock Issued During Period Shares Stock Options Exercised Equity component of convertible debt, net of issuance costs Adjustments To Additional Paid In Capital Equity Component Of Convertible Debt Ending balance Ending balance (in shares) The amount of increase (decrease) in cease-use expense during the period, including amounts related to sublease agreements. Increase (decrease) in reimbursements of tenant improvements. Statement Of Cash Flows [Abstract] CASH FLOWS FROM OPERATING ACTIVITIES Net Cash Provided By Used In Operating Activities [Abstract] Net income (loss) Profit Loss Reconciliation of net income (loss) to net cash provided by (used in) operating activities: Adjustments To Reconcile Net Income Loss To Cash Provided By Used In Operating Activities [Abstract] Depreciation and amortization Depreciation And Amortization Amortization of debt discount Amortization Of Debt Discount Premium Amortization of debt issuance costs Amortization Of Financing Costs Amortization of premiums on investments Accretion Amortization Of Discounts And Premiums Investments Share-based compensation expense Share Based Compensation Deferred rent Increase Decrease In Deferred Liabilities Gain on sales of assets, net Gains Losses On Sales Of Assets Cease-use expense Increase Decrease In Cease Use Expense Change in operating assets and liabilities: Increase Decrease In Operating Capital [Abstract] Accounts receivable Increase Decrease In Accounts Receivable Inventory Increase Decrease In Inventories Reimbursements for tenant improvements Increase Decrease In Reimbursements Of Tenant Improvements Accounts payable and accrued liabilities Increase Decrease In Accounts Payable And Accrued Liabilities Other current assets and liabilities, net Increase Decrease In Other Current Assets And Liabilities Net Net cash provided by (used in) operating activities Net Cash Provided By Used In Operating Activities CASH FLOWS FROM INVESTING ACTIVITIES Net Cash Provided By Used In Investing Activities [Abstract] Purchases of investments Payments To Acquire Investments Sales and maturities of investments Proceeds From Sale And Maturity Of Marketable Securities Purchases of property and equipment Payments To Acquire Property Plant And Equipment Proceeds from sales of property and equipment Proceeds From Sale Of Property Plant And Equipment Net cash (used in) provided by investing activities Net Cash Provided By Used In Investing Activities CASH FLOWS FROM FINANCING ACTIVITIES Net Cash Provided By Used In Financing Activities [Abstract] Issuance of common stock Proceeds From Issuance Of Common Stock Proceeds from issuance of senior convertible notes, net Proceeds From Convertible Debt Net cash provided by financing activities Net Cash Provided By Used In Financing Activities Net change in cash, cash equivalents, and restricted cash Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Period Increase Decrease Including Exchange Rate Effect Cash, cash equivalents, and restricted cash at beginning of the period Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Cash, cash equivalents, and restricted cash at end of the period SUPPLEMENTAL DISCLOSURES Supplemental Cash Flow Information [Abstract] Cash paid for interest Interest Paid Net Non-cash capital expenditures Capital Expenditures Incurred But Not Yet Paid Accounting Policies [Abstract] ORGANIZATION AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES Business Description And Accounting Policies [Text Block] The entire disclosure for revenue recognition and collaborative research and development arrangements in which the entity is a participant, including a) information about the nature of the collaborative and license arrangements; and b) the amounts attributable to transactions arising from these collaborative arrangements. Text Block [Abstract] SIGNIFICANT COLLABORATIVE RESEARCH AND DEVELOPMENT AGREEMENTS Significant Collaborative Research And Development Agreements [Text Block] Investments Debt And Equity Securities [Abstract] INVESTMENTS Investments In Debt And Marketable Equity Securities And Certain Trading Assets Disclosure [Text Block] Fair Value Disclosures [Abstract] FAIR VALUE MEASUREMENTS Fair Value Disclosures [Text Block] Debt Disclosure [Abstract] CONVERTIBLE SENIOR NOTES Debt Disclosure [Text Block] Other balance sheet details. Other Balance Sheet Details [Abstract] OTHER BALANCE SHEET DETAILS Supplemental Balance Sheet Disclosures [Text Block] NET INCOME (LOSS) PER SHARE Earnings Per Share [Text Block] Disclosure Of Compensation Related Costs Sharebased Payments [Abstract] SHARE-BASED COMPENSATION Disclosure Of Compensation Related Costs Share Based Payments [Text Block] Income Tax Disclosure [Abstract] INCOME TAXES Income Tax Disclosure [Text Block] Leases [Abstract] LEASES Leases Of Lessee Disclosure [Text Block] Compensation And Retirement Disclosure [Abstract] RETIREMENT PLAN Pension And Other Postretirement Benefits Disclosure [Text Block] Commitments And Contingencies Disclosure [Abstract] COMMITMENTS AND CONTINGENCIES Commitments And Contingencies Disclosure [Text Block] Subsequent Events [Abstract] SUBSEQUENT EVENTS Subsequent Events [Text Block] Quarterly Financial Information Disclosure [Abstract] SELECTED QUARTERLY FINANCIAL DATA (UNAUDITED) Quarterly Financial Information [Text Block] Business Description Policy [Text Block] Business Activities Business Description Policy [Text Block] Principles of Consolidation Consolidation Policy [Text Block] Use of Estimates Use Of Estimates Industry Segment and Geographic Information Segment Reporting Policy Policy [Text Block] Cash Equivalents Cash And Cash Equivalents Policy [Text Block] Short-Term and Long-Term Investments Available-for-Sale Marketable Securities Policy Accounts Receivable Receivables Policy [Text Block] Fair Value of Financial Instruments Fair Value Of Financial Instruments Policy Inventory Inventory Policy [Text Block] Property and Equipment Property Plant And Equipment Policy [Text Block] Impairment of Long-Lived Assets Impairment Or Disposal Of Long Lived Assets Policy [Text Block] Revenue Recognition Revenue From Contract With Customer Policy [Text Block] Concentration of Credit Risk Concentration Risk Credit Risk Cost of Sales Cost Of Sales Policy [Text Block] Research and Development Expenses Research And Development Expense Policy Advertising Expense Advertising Costs Policy [Text Block] Share-Based Compensation Share Based Compensation Option And Incentive Plans Policy Net Income (Loss) Per Share Earnings Per Share Policy [Text Block] Recently Adopted Accounting Pronouncements New Accounting Pronouncements Policy Policy [Text Block] Recently issued accounting pronouncements. Recently Issued Accounting Pronouncements Recently Issued Accounting Pronouncements Policy [Text Block] Investments Schedule [Abstract] Investments Debt Securities Available For Sale Table [Text Block] Summary of Investments Classified as Available-For-Sale Securities Schedule Of Available For Sale Securities Reconciliation Table [Text Block] Gross Unrealized Losses and Fair Value Available-For-Sale Investments in Unrealized Loss Position Debt Securities Available For Sale Unrealized Loss Position Fair Value Table [Text Block] Assets Measured at Fair Value on Recurring Basis Fair Value Assets Measured On Recurring Basis [Text Block] Convertible Senior Notes Net of Discounts and Deferred Financing Costs Schedule Of Debt Instruments [Text Block] Summary of Inventory Schedule Of Inventory Current Table [Text Block] Property and Equipment Property Plant And Equipment [Text Block] Accounts Payable and Accrued Liabilities Schedule Of Accounts Payable And Accrued Liabilities Table [Text Block]