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Disclosure - SIGNIFICANT COLLABORATIVE RESEARCH AND DEVELOPMENT AGREEMENTS link:calculationLink link:presentationLink link:definitionLink 100080 - Disclosure - INVESTMENTS link:calculationLink link:presentationLink link:definitionLink 100090 - Disclosure - FAIR VALUE MEASUREMENTS link:calculationLink link:presentationLink link:definitionLink 100100 - Disclosure - CONVERTIBLE SENIOR NOTES link:calculationLink link:presentationLink link:definitionLink 100110 - Disclosure - OTHER BALANCE SHEET DETAILS link:calculationLink link:presentationLink link:definitionLink 100120 - Disclosure - NET INCOME (LOSS) PER SHARE link:calculationLink link:presentationLink link:definitionLink 100130 - Disclosure - SHARE-BASED COMPENSATION link:calculationLink link:presentationLink link:definitionLink 100140 - Disclosure - INCOME TAXES link:calculationLink link:presentationLink link:definitionLink 100150 - Disclosure - LEASES link:calculationLink link:presentationLink link:definitionLink 100160 - Disclosure - 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Disclosure - NET INCOME (LOSS) PER SHARE (Tables) link:calculationLink link:presentationLink link:definitionLink 100260 - Disclosure - SHARE-BASED COMPENSATION (Tables) link:calculationLink link:presentationLink link:definitionLink 100270 - Disclosure - INCOME TAXES (Tables) link:calculationLink link:presentationLink link:definitionLink 100280 - Disclosure - SELECTED QUARTERLY FINANCIAL DATA (UNAUDITED) (Tables) link:calculationLink link:presentationLink link:definitionLink 100290 - Disclosure - Organization and Summary of Significant Accounting Policies - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100300 - Disclosure - Significant Collaborative Research and Development Agreements - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100310 - Disclosure - Investments (Detail) link:calculationLink link:presentationLink link:definitionLink 100320 - Disclosure - Summary of Investments Classified as Available-For-Sale Securities (Detail) link:calculationLink link:presentationLink link:definitionLink 100330 - Disclosure - Gross Unrealized Losses and Fair Value Available-For-Sale Investments in Unrealized Loss Position (Detail) link:calculationLink link:presentationLink link:definitionLink 100340 - Disclosure - Assets Measured at Fair Value on Recurring Basis (Detail) link:calculationLink link:presentationLink link:definitionLink 100350 - Disclosure - Fair Value Measurements - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100360 - Disclosure - Convertible Senior Notes - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100370 - Disclosure - Convertible Senior Notes - Convertible Senior Notes, Net of Discounts and Deferred Financing Costs (Detail) link:calculationLink link:presentationLink link:definitionLink 100380 - Disclosure - Other Balance Sheet Details - Summary of Inventory (Detail) link:calculationLink link:presentationLink link:definitionLink 100390 - Disclosure - Other Balance Sheet Details - 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Disclosure - Summary and Changes in Stock Options Outstanding (Detail) link:calculationLink link:presentationLink link:definitionLink 100470 - Disclosure - Summary and Changes in Restricted Stock Units Outstanding (Detail) link:calculationLink link:presentationLink link:definitionLink 100480 - Disclosure - Components of Income Tax Expense for Continuing Operations (Detail) link:calculationLink link:presentationLink link:definitionLink 100490 - Disclosure - Provision for Income Taxes on Earnings Subject to Income Taxes Differs from Statutory Federal Rate (Detail) link:calculationLink link:presentationLink link:definitionLink 100500 - Disclosure - Provision for Income Taxes on Earnings Subject to Income Taxes Differs from Statutory Federal Rate (Parenthetical) (Detail) link:calculationLink link:presentationLink link:definitionLink 100510 - Disclosure - Income Taxes - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100520 - Disclosure - Components of Deferred Tax Assets (Detail) link:calculationLink link:presentationLink link:definitionLink 100530 - Disclosure - Activity Related to Unrecognized Tax Benefits (Detail) link:calculationLink link:presentationLink link:definitionLink 100540 - Disclosure - Leases - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100550 - Disclosure - Retirement Plan - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100560 - Disclosure - Commitments and Contingencies - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100570 - Disclosure - Subsequent Events - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100580 - Disclosure - Summary of Quarterly Results of Operations (Detail) link:calculationLink link:presentationLink link:definitionLink