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                       SECURITIES AND EXCHANGE COMMISSION

                             WASHINGTON, D.C. 20549

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                                    FORM 8-K

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                                 CURRENT REPORT

                     Pursuant to Section 13 or 15(d) of the

                         Securities Exchange Act of 1934

     Date of Report (Date of the earliest event reported): November 27, 2001


                          NEUROCRINE BIOSCIENCES, INC.
             (Exact name of registrant as specified in its charter)

    DELAWARE                      0-28150                      33-0525145
(State or other            (Commission File Number)           (IRS Employer
 jurisdiction of                                          Identification Number)
 incorporation)

    10555 SCIENCE CENTER DRIVE, SAN DIEGO, CA                      92121
     (Address of principal executive offices)                   (Zip Code)

       Registrant's telephone number, including area code: (858) 658-7600



                                       N/A
         (Former name or former address, if changed since last report.)

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     This Current Report on Form 8-K is filed by Neurocrine Biosciences, Inc., a
Delaware  corporation (the "Company"),  in connection with the matters described
herein.


ITEM 5.  OTHER EVENTS

         On November 27, 2001,  the Company  announced that it intends to file a
preliminary   prospectus   supplement  to  its  $200  million   universal  shelf
registration  statement with the Securities and Exchange  Commission relating to
the proposed  underwritten  public  offering of  3,250,000  shares of its common
stock. A copy of the Company's press release  announcing its intention to file a
preliminary prospectus  supplement,  dated November 27, 2001, is attached hereto
as Exhibit 99.1 and incorporated herein by reference.

ITEM 7.  EXHIBITS

         (c)      Exhibits.   The following exhibits are filed herewith:


                 Exhibit
                 Number       Description of Exhibit
                ------------  -----------------------------------------
                 99.1         Press Release, dated November 27, 2001.






                                   SIGNATURES

     Pursuant to the  requirements  of the  Securities and Exchange Act of 1934,
the  registrant  has duly  caused  this report to be signed on its behalf by the
undersigned thereunto duly authorized.

Dated:   November 27, 2001                        /s/ Paul W. Hawran
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                                                  Paul W. Hawran
                                                  Executive Vice President and
                                                  Chief Financial Officer





EXHIBIT INDEX EXHIBIT NUMBER DESCRIPTION - -------- ------------------------------------------------------------ 99.1 Press Release, dated November 27, 2001.

                                                                    Exhibit 99.1

FOR IMMEDIATE RELEASE
Contact at Neurocrine Biosciences
Elizabeth Foster or Paul Hawran
(858) 658-7600


              NEUROCRINE BIOSCIENCES TO FILE PRELIMINARY PROSPECTUS
                 SUPPLEMENT FOR 3,250,000 SHARE PUBLIC OFFERING

San Diego,  CA, November 27,  2001-Neurocrine  Biosciences,  Inc.  (NASDAQ:NBIX)
today announced that it intends to file a preliminary  prospectus  supplement to
its $200 million universal shelf registration  statement with the Securities and
Exchange  Commission  relating to the proposed  underwritten  public offering of
3,250,000  shares of its common  stock.  The company  also  proposes to grant an
option to the  underwriters  to  purchase up to 487,500  shares of common  stock
solely to cover over-allotments.  All of the shares are being sold by Neurocrine
Biosciences.

The joint  bookrunning  managers for the offering  announced  today are Deutsche
Banc Alex. Brown and Credit Suisse First Boston Corporation. Co-managers of this
offering are CIBC World Markets  Corp.,  Lehman  Brothers  Inc., and UBS Warburg
LLC.

A preliminary  prospectus  supplement relating to the shares referenced above is
expected to be filed with the Securities and Exchange Commission tomorrow. These
securities  may not be sold nor may offers to buy be accepted  prior to the time
that the prospectus supplement is final. This communication shall not constitute
an offer to sell or the  solicitation  of an offer to buy nor shall there be any
sale of these securities in any state in which such offer,  solicitation or sale
would be unlawful prior to  registration of  qualification  under the securities
laws of any such state.

Neurocrine  Biosciences,  Inc.  is  a  product-based  biopharmaceutical  company
focused on  neurological  and  endocrine  diseases  and  disorders.  Our product
candidates  address  some of the  largest  pharmaceutical  markets  in the world
including insomnia, anxiety,  depression,  malignant brain tumors and peripheral
cancers,  diabetes,   multiple  sclerosis,   irritable  bowel  syndrome,  eating
disorders, pain, stroke, and certain female health disorders.

Copies  of the  preliminary  prospectus  supplement  may be  obtained  from  the
Prospectus   Departments  at  Deutsche  Banc  Alex.  Brown,  One  South  Street,
Baltimore,  MD 21202,  (410) 895-2070,  Credit Suisse First Boston  Corporation,
Eleven Madison Avenue, New York, NY 10010, (212) 325-2000 or from the offices of
any of the managing underwriters identified above.

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