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                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                              _____________________


                                    FORM 10-Q

(Mark One)

[X] QUARTERLY  REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES AND
    EXCHANGE ACT OF 1934

                  For the quarterly period ended September 30, 2001

                                       OR

[ ] TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES AND
    EXCHANGE ACT OF 1934

For the transition period from ______________________ to ____________________


                         COMMISSION FILE NUMBER 0-28150


                            NEUROCRINE BIOSCIENCES, INC.
             (Exact name of registrant as specified in its charter)

              DELAWARE                                   33-0525145
   (State or other jurisdiction of            (IRS Employer Identification No.)
    incorporation or organization)

                           10555 SCIENCE CENTER DRIVE
                           SAN DIEGO, CALIFORNIA 92121
                    (Address of principal executive offices)

                                (858) 658-7600
              (Registrant's telephone number, including area code)


     Indicate  by check mark  whether the  registrant  (1) has filed all reports
required to be filed by Section 13 or 15(d) of the  Securities  Exchange  Act of
1934  during  the  preceding  12 months  (or for such  shorter  period  that the
registrant was required to file such reports),  and (2) has been subject to such
filing requirements for the past 90 days:

                              Yes X              No

     The number of  outstanding  shares of the  registrant's  Common Stock,  par
value of $0.001, was 26,212,635 as of October 31, 2001.

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                           NEUROCRINE BIOSCIENCES, INC.
                                 FORM 10-Q INDEX


                                                                          PAGE
PART I.  FINANCIAL INFORMATION

  ITEM 1:  Financial Statements.............................................3

           Condensed Balance Sheets as of September 30, 2001
              and December 31, 2000.........................................3

           Condensed Statements of Operations for the three and nine months
              ended September 30, 2001 and 2000.............................4

           Condensed Statements of Cash Flows for nine months
              ended September 30, 2001 and 2000.............................5

           Notes to the Condensed Financial Statements......................6

  ITEM 2:  Management's Discussion and Analysis of Financial Condition
              and Results of Operations.....................................7

  ITEM 3:  Quantitative and Qualitative Disclosures About Market Risk......11

PART II. OTHER INFORMATION

  ITEM 6:  Exhibits and Reports on Form 8-K................................11

           SIGNATURES......................................................11




                         PART I. FINANCIAL INFORMATION

ITEM 1.  Financial Statements

                          NEUROCRINE BIOSCIENCES, INC.
                            CONDENSED BALANCE SHEETS
                                 (in thousands)


                                                      September 30, December 31,
                                                          2001         2000
                                                       (unaudited)
                                                      ------------- ------------


                                   ASSETS
Current assets:
  Cash and cash equivalents .............................$  11,946    $  21,078
  Short-term investments, available-for-sale ............  129,309      143,592
  Receivables under collaborative agreements ............   19,710        5,974
  Other current assets ..................................    1,704        1,761
                                                         ----------   ----------
       Total current assets .............................  162,669      172,405

Property and equipment, net .............................   12,653       11,300
Licensed technology and patent applications costs, net ..      245          362
Other assets ............................................    2,387        1,895
                                                         ----------   ----------
       Total assets .....................................$ 177,954    $ 185,962
                                                         ==========   ==========


                     LIABILITIES AND STOCKHOLDERS' EQUITY
Current liabilities:
  Accounts payable ......................................$   1,354    $   1,065
  Accrued liabilities ...................................   11,119       11,135
  Deferred revenues .....................................    8,243        1,172
  Current portion of long-term debt .....................      149          149
  Current portion of capital lease obligations ..........    1,545        1,438
                                                         ----------   ----------
     Total current liabilities ..........................   22,410       14,959

Long-term debt, net of current portion ..................       37          162
Capital lease obligations, net of current portion .......    2,005        2,121
Deferred rent ...........................................    4,996        1,646
Deferred revenues .......................................    2,075        2,890
Other liabilities .......................................      898          976
                                                         ----------   ----------
       Total liabilities  ...............................   32,421       22,754

Stockholders' equity:
  Preferred stock, $0.001 par value; 5,000,000 shares
     authorized; no shares issued and outstanding .......        -            -
  Common stock, $0.001 par value; 50,000,000 shares
     authorized; issued and outstanding shares were
     26,187,852 in 2001 and 25,314,470 in 2000 ..........       26           25
  Additional paid in capital ............................  238,880      233,565
  Deferred compensation .................................     (444)         (59)
  Stockholder notes  ....................................     (104)        (104)
  Accumulated other comprehensive income (loss) .........      (45)         261
  Accumulated deficit  ..................................  (92,780)     (70,480)
                                                         ----------   ----------
       Total stockholders' equity  ......................  145,533      163,208
                                                         ----------   ----------
       Total liabilities and stockholders' equity .......$ 177,954    $ 185,962
                                                         ==========   ==========

          See accompanying notes to the condensed financial statements.



                          NEUROCRINE BIOSCIENCES, INC.
                       CONDENSED STATEMENTS OF OPERATIONS
              (unaudited; in thousands except per share data)


                                       Three Months Ended    Nine Months Ended
                                         September 30,         September 30,
                                      --------------------  --------------------
                                        2001       2000       2001       2000
                                                (restated)            (restated)
                                      --------------------  --------------------
Revenues:
  Sponsored research and development .$  5,104   $  1,887   $ 10,948   $  4,943
  License and option fees ............     501        152        959      2,152
  Milestones .........................  15,500          -     15,500          -
  Grant income and other revenues ....     488        386      1,002      1,050
                                      --------------------  --------------------
      Total revenues .................  21,593      2,425     28,409      8,145

Operating expenses:
  Research and development ...........  18,327     12,499     49,583     28,404
  General and administrative .........   2,073      2,509      7,304      6,930
                                      --------------------  --------------------
     Total operating expenses ........  20,400     15,008     56,887     35,334

                                       -------------------  --------------------
Income (loss) from operations ........   1,193    (12,583)   (28,478)   (27,189)

Other income and (expenses):

  Interest income ....................   1,254      1,431      5,965      4,466
  Interest expense ...................     (79)       (61)      (223)      (173)
  Other income and expenses, net .....     139        282        436        926
                                       -------------------  --------------------


Income (loss) before income taxes ....   2,507    (10,931)   (22,300)   (21,970)


Income taxes .........................       -        102          -        302
                                       -------------------  --------------------

Net income (loss) ....................$  2,507   $(11,033)  $(22,300)  $(22,272)
                                      ====================  ====================

Income (loss) per common share:
  Basic                               $   0.10   $  (0.50)  $  (0.87)  $  (1.02)
  Diluted                             $   0.09   $  (0.50)  $  (0.87)  $  (1.02)

Shares used in the calculation of loss per common share:
  Basic                                 25,816     22,032     25,575     21,900
  Diluted                               27,972     22,032     25,575     21,900





          See accompanying notes to the condensed financial statements.



                          NEUROCRINE BIOSCIENCES, INC.
                        CONDENSED STATEMENTS OF CASH FLOWS
                            (unaudited; in thousands)

                                                             Nine Months Ended
                                                               September 30,
                                                         -----------------------
                                                            2001         2000
                                                                      (restated)
                                                         ----------   ----------
CASH FLOW FROM OPERATING ACTIVITIES
Net loss ................................................$ (22,300)   $ (22,272)
Adjustments to reconcile net loss to net cash
  provided by/(used in) operating activities:
      Loss on asset disposal ............................       51            -
      Depreciation and amortization .....................    1,918        1,618
      Deferred revenues .................................    9,177        2,791
      Deferred expenses .................................      352          785
      Compensation expenses for stock options ...........    1,585        1,986
      Change in operating assets and liabilities:
           Accounts receivable and other current assets .  (13,680)         545
           Other non-current assets .....................     (238)         837
           Accounts payable and accrued liabilities .....    1,188          886
                                                         ----------   ----------
Net cash flows used in operating activities .............  (21,947)     (12,824)

CASH FLOW FROM INVESTING ACTIVITIES
Purchases of short-term investments .....................  (73,953)     (25,140)
Sales/maturities of short-term investments ..............   87,930       26,775
Purchases of property and equipment .....................   (3,459)      (1,688)
                                                         ----------   ----------
Net cash flows provided by/(used in) investing activities   10,518          (53)

CASH FLOW FROM FINANCING ACTIVITIES
Issuance of common stock ................................    2,431        2,816
Proceeds from capital lease financing ...................    1,011          650
Principal payments on long-term obligations .............   (1,145)        (706)
Payments received on notes receivable from stockholders .        -           15
                                                         ----------   ----------
Net cash flows provided by financing activities .........    2,297        2,775
                                                         ----------   ----------
Net decrease in cash and cash equivalents ...............   (9,132)     (10,102)

Cash and cash equivalents at beginning of the period ....   21,078       21,265
                                                         ----------   ----------
Cash and cash equivalents at end of the period ..........$  11,946    $  11,163
                                                         ==========   ==========






          See accompanying notes to the condensed financial statements.



                          NEUROCRINE BIOSCIENCES, INC.
                   NOTES TO THE CONDENSED FINANCIAL STATEMENTS
                                   (unaudited)


1.   BASIS OF PRESENTATION

     The condensed financial  statements included herein are unaudited.  Certain
reclassifications  have  been  made to prior  year  amounts  to  conform  to the
presentation  for the three and nine months  ended  September  30,  2001.  These
statements have been prepared in accordance with generally  accepted  accounting
principles for interim  financial  information and with the  instructions of the
Securities  and  Exchange  Commission  (SEC)  on Form  10-Q  and  Rule  10-01 of
Regulation  S-X.  Accordingly,  they do not include all of the  information  and
footnotes  required by generally  accepted  accounting  principles  for complete
financial statements.  In the opinion of management,  these financial statements
include all adjustments  (consisting of normal recurring  adjustments) necessary
for a fair presentation of the financial  position,  results of operations,  and
cash flows for the periods presented.

     The results of operations for the interim  periods shown in this report are
not necessarily  indicative of results expected for the full year. The financial
statements should be read in conjunction with the audited  financial  statements
and notes for the year ended December 31, 2000, included in our Annual Report on
Form 10-K filed with the SEC.


2.   USE OF ESTIMATES

     The  preparation  of financial  statements  in  conformity  with  generally
accepted  accounting  principles  requires  management  to  make  estimates  and
assumptions  that affect the reported  amounts of assets and  liabilities at the
date of the  financial  statements  and the  reported  amounts of  revenues  and
expenses during the period. Actual results could differ from those estimates.


3.   NET EARNINGS OR LOSS PER COMMON SHARE

     Basic  net  earnings  or loss per  common  share is  calculated  using  the
weighted average number of common shares outstanding during the period.  Diluted
net  earnings  or loss per  common  share is  calculated  by  adding  the  total
incremental  number of common share  equivalents and the weighted average number
of common shares  outstanding during the period using the treasury stock method.
Except for the quarter ending September 30, 2001, the incremental  shares of the
common  share   equivalents  for  all  other  periods  were  excluded  from  the
calculation of diluted net loss per share as their effects were antidilutive.


4.   COMPREHENSIVE INCOME

     Our  comprehensive  losses consist of net losses and  unrealized  gains and
losses  on  investments.  The  accumulated  balances  of  these  components  are
disclosed as a separate component of stockholders' equity.


5.   REVENUE RECOGNITION

     During the fourth  quarter of 2000, the Company  adopted SAB 101,  "Revenue
Recognition  in Financial  Statements".  SAB 101  provides,  among other revenue
items,  guidance in the recognition of nonrefundable,  up-front fees received in
conjunction  with a  research  and  development  agreement.  The  result  of the
adoption of SAB 101 was to reduce  recognition of license fee revenues  reported
during the third quarter of 2000 by $2.9 million,  increasing net loss per share
by $0.13 for the three and nine months ended September 30, 2000.  These revenues
were deferred and will be recognized as income, ratably over the estimated lives
of the respective agreements.



     Milestones are recognized as revenue when earned.  The earnings  process is
considered  complete  when the  milestone  coincides  with the  occurrence  of a
contract specified event and represents the completion of a substantive  element
of an  arrangement.  In July  2001,  the  Company  and Glaxo  Group  Limited,  a
subsidiary  of  GlaxoSmithKline  (GSK),  signed a  worldwide  collaboration  and
license agreement to engage in the research,  development and  commercialization
of Corticotropin  Releasing Factor Receptor Antagonist Compounds.  Under the GSK
agreement,  we completed and  recognized a $15.5 million  milestone in September
2001.


6.   NEW ACCOUNTING PRONOUNCEMENTS

     In July 2001, the Financial  Accounting  Standards Board (FASB) issued FASB
Statements Nos. 141 and 142 (FAS 141 and FAS 142),  "Business  Combinations" and
"Goodwill and Other  Intangible  Assets." FAS 141 replaces APB 16 and eliminates
pooling-of-interests  accounting  prospectively.  It also  provides  guidance on
purchase  accounting  related  to  the  recognition  of  intangible  assets  and
accounting  for negative  goodwill.  FAS 142 changes the accounting for goodwill
from an  amortization  method to an  impairment  only  approach.  Under FAS 142,
goodwill  will be reviewed  annually and also whenever  events or  circumstances
occur  indicating  that  goodwill  might  be  impaired.  FAS 141 and FAS 142 are
effective  for all business  combinations  completed  after June 30, 2001.  Upon
adoption of FAS 142, amortization of goodwill recorded for business combinations
consummated  prior to July 1, 2001 will cease,  and intangible  assets  acquired
prior to July 1, 2001 that do not meet the  criteria for  recognition  under FAS
141 will be  reclassified  to goodwill.  Companies are required to adopt FAS 142
for fiscal  years  beginning  after  December 15,  2001,  but early  adoption is
permitted  under certain  circumstances.  The adoption of these standards is not
expected to have a material  impact on the Company's  results of operations  and
financial position.


ITEM 2:  MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND
            RESULTS OF OPERATIONS

     The following  Management's  Discussion and Analysis of Financial Condition
and Results of Operations  section  contains  forward-looking  statements  which
involve  risks  and   uncertainties,   pertaining   generally  to  the  expected
continuation of our collaborative  agreements,  the receipt of research payments
there under, the future achievement of various milestones in product development
and the receipt of payments  related thereto,  the potential  receipt of royalty
payments,  pre-clinical  testing and clinical trials of potential products,  the
period  of time  that our  existing  capital  resources  will  meet our  funding
requirements, and our financial results and operations. Our actual results could
differ materially from those anticipated in these forward-looking  statements as
a result of various factors,  including those set forth below and those outlined
in our 2000  Annual  Report on Form 10-K and the most recent Form S-3 filed with
the SEC.


OVERVIEW

     We  incorporated  in California in 1992 and  reincorporated  in Delaware in
1996.  Since  we were  founded,  we  have  been  engaged  in the  discovery  and
development  of novel  pharmaceutical  products  for  neurologic  and  endocrine
diseases  and  disorders.  Our product  candidates  address  some of the largest
pharmaceutical  markets in the world including  insomnia,  anxiety,  depression,
cancer and  diabetes.  To date, we have not generated any revenues from the sale
of  products,  and we do not expect to  generate  any  product  revenues  in the
foreseeable future. We have funded our operations  primarily through private and
public  offerings of our common stock and payments  received  under research and
development  agreements.  We are  developing a number of products with corporate
collaborators and will rely on existing and future collaborators to meet funding
requirements.  We expect to  generate  future  net  losses  in  anticipation  of
significant  increases in operating  expenses as product candidates are advanced
through the various stages of clinical development. As of September 30, 2001, we
have  incurred  a  cumulative  deficit  of $92.8  million  and  expect  to incur
operating losses in the future, which may be greater than losses in prior years.





RESULTS OF OPERATIONS

                 THREE MONTHS ENDED SEPTEMBER 30, 2001 AND 2000

     Revenues for the third  quarter of 2001 were $21.6  million  compared  with
$2.4 million for the same period last year.  The increase in revenues  from last
year  to  this  year  resulted   primarily  from  revenues  received  under  the
GlaxoSmithKline (GSK) and Taisho  Pharmaceuticals Co., Ltd. (Taisho) agreements.
On July 20, 2001,  the Company and Glaxo Group  Limited,  a  subsidiary  of GSK,
signed  a  worldwide  collaboration  and  license  agreement  to  engage  in the
research,  development and  commercialization of Corticotropin  Releasing Factor
Receptor  Antagonist  Compounds.  Under the GSK  agreement,  we recognized  $1.6
million in license and sponsored  research and  development  funding and a $15.5
million  milestone.  We also  recognized  $2.5 million in license and  sponsored
development  fees,  and  $713,000 in  sponsored  research  related to the Taisho
agreement this quarter compared to $538,000 in license and sponsored development
fees in the same  quarter  last  year.  The  increase  in  revenues  from  these
agreements  was partially  offset by the  completion  of the sponsored  research
portion of the 1999  Janssen  Pharmaceutica,  N.V.  (Janssen)  agreement.  These
activities  concluded,  as  scheduled,  in  February  2001.  Under  the  Janssen
agreement, we received $743,000 in sponsored research and development during the
third quarter of 2000.

     Research and development  expenses increased to $18.3 million for the third
quarter of 2001 compared with $12.5 million for the  respective  period in 2000.
Increased  expenses  primarily  reflect higher costs  associated  with expanding
development  activities and the addition of scientific and clinical  development
personnel.  Currently,  we have 15  programs  in our  research  and  development
pipeline. Five of these programs are in clinical development, three programs are
in  advanced  pre-clinical  development  and  seven  are in  various  stages  of
research.  We expect to incur  significant  increases in future periods as later
phases of development typically involve an increase in the scope of studies, the
number of patients  treated and the number of scientific  personnel  required to
manage the clinical trials.

     General and administration expenses decreased to $2.1 million for the third
quarter of 2001 compared with $2.5 million during the same period last year. The
decrease  resulted  primarily from lower  management  consulting fees associated
with the Taisho agreement.

     Interest income  decreased to $1.3 million during the third quarter of 2001
compared to $1.4  million  for the same  period last year.  Even though the cash
balance  was higher in the third  quarter  of 2001  compared  to 2000,  interest
income was lower as a result of declining interest rates in 2001.

     Net income for the third  quarter  of 2001 was $2.5  million,  or $0.10 per
share,  compared to a net loss $11.0 million,  or $0.50 per share,  for the same
period in 2000.  The  increase to a net income was  primarily  the result of the
GlaxoSmithKline  revenue  recognized in the third quarter of 2001. The increased
revenue  was  partially  offset  from the cost of  expanded  testing of our five
clinical  programs  and the  addition of  scientific  and  clinical  development
personnel.  We expect net losses in the fourth  quarter and year-end 2001 as our
programs  continue to advance  through the various  stages of the  research  and
clinical development processes.

     To date,  the  Company's  revenues  have  come  from  funded  research  and
achievements of milestones under corporate collaborations. The nature and amount
of these revenues from period to period may lead to substantial  fluctuations in
the  results of  quarterly  revenues  and  earnings.  Accordingly,  results  and
earnings of one period are not predictive of future periods.

                NINE MONTHS ENDED SEPTEMBER 30, 2001 AND 2000

     Revenues for the nine months ended  September  30, 2001 were $28.4  million
compared  with $8.1 million in 2000.  The  increase  from last year to this year
resulted  primarily from revenues received under the GSK and Taisho  agreements.
Under the new GSK agreement, we recognized $1.6 million in license and sponsored
research and development  funding and a $15.5 million milestone in 2001. We also
recognized $7.0 million in sponsored  research and development,  and $579,000 in
license fees related to the Taisho  agreement in the nine months ended September
30, 2001  compared to $2.2  million in option and license  fees and  $388,000 in
sponsored  development fees for the respective period last year. The increase in
revenues from these  agreements  was partially  offset by the  completion of the
sponsored research portion of the Janssen agreement. These activities concluded,
as  scheduled,  in  February  2001.  Under the  Janssen  agreement,  we received
$342,000 and $2.2 million for the nine months ended September 30, 2001 and 2000,
respectively.



     Research and development  expenses increased to $49.6 million for the first
nine months of 2001  compared with $28.4  million for the  respective  period in
2000.   Increased  expenses  primarily  reflect  higher  costs  associated  with
expanding  development  activities  and the addition of scientific  and clinical
development  personnel.  Currently,  we have 15  programs  in our  research  and
development pipeline. Five of these programs are in clinical development,  three
programs  are in  advanced  pre-clinical  development  and seven are in  various
stages of research.  We expect to incur significant  increases in future periods
as later  phases of  development  typically  involve an increase in the scope of
studies,  the number of patients treated and the number of scientific  personnel
required to manage the clinical trials.

     General and administration  expenses increased to $7.3 million for the nine
months ended  September  30, 2001  compared  with $6.9  million  during the same
period last year. The increase resulted from additional administrative personnel
expenses,   primarily  recruiting  and  relocation,   and  professional  service
expenses,  predominantly  legal  costs to  support  the  expanded  research  and
clinical  development  efforts.  The  increase  was  partially  offset  by lower
management consulting fees associated with the Taisho agreement.

     Interest  income  increased  to $6.0  million  for the first nine months of
2001,  compared to $4.5  million for the same  period last year.  Despite  lower
interest rates in 2001 compared to 2000,  interest income  increased  because of
higher  investment  balances  achieved through offerings of our common stock. In
December 2000, we sold 3.2 million shares in a public  offering,  which resulted
in net proceeds of $90.4 million. Due to the increase in cash reserves generated
from this  transaction,  we  anticipate  interest  income  for this year will be
higher than that of last year.

     Net loss for the first nine months of 2001 was $22.3 million,  or $0.87 per
share  compared  to $22.3  million,  or $1.02 per share,  for the same period in
2000.  Higher costs in 2001 from expanded testing of our five clinical  programs
and the addition of scientific and clinical development personnel were offset by
the increase in third quarter revenues. Net losses are expected to increase this
year as our  programs  continue to advance  through  the  various  stages of the
research and clinical development processes.

     To date,  the  Company's  revenues  have  come  from  funded  research  and
achievements of milestones under corporate collaborations. The nature and amount
of these revenues from period to period may lead to substantial  fluctuations in
the  results of  quarterly  revenues  and  earnings.  Accordingly,  results  and
earnings of one period are not predictive of future periods.



LIQUIDITY AND CAPITAL RESOURCES

     At  September  30,  2001,  our  cash,  cash  equivalents,   and  short-term
investments  totaled $141.3 million compared with $164.7 million at December 31,
2000.  The decrease in cash balances at September  30, 2001  resulted  primarily
from funding of operations.

     Net  cash  used by  operating  activities  during  the  nine  months  ended
September 30, 2001 was $21.9 million compared with $12.8 million during the same
period last year.  The increase in cash used in  operations  resulted  primarily
from the  increase  in  clinical  development  activities  and the  addition  of
scientific and clinical development personnel.

     Net cash  provided by  investing  activities  during the nine months  ended
September  30, 2001 was $10.5  million  compared to net cash used of $53,000 for
the first nine months of 2000.  This  fluctuation  resulted  primarily  from the
timing  differences  in the  investment  purchases,  sales,  maturities  and the
fluctuations  in our  portfolio  mix between  cash  equivalents  and  short-term
investment  holdings.  We expect  similar  fluctuations  to  continue  in future
periods. Capital equipment purchases for 2001 will be financed primarily through
leasing  agreements and are expected to be approximately $4.0 million this year,
of which $3.5 million has been incurred in the nine months ending  September 30,
2001.

     Net cash provided by financing  activities  during the first nine months of
2001 was $2.3 million compared with $2.8 million for the respective  period last
year.  Cash proceeds from the issuance of common stock under option and employee
purchase  programs  was $2.4  million and $2.8  million in the nine months ended
September 30, 2001 and 2000, respectively.  In addition, capital lease financing



provided  $1.0 million in cash during the first nine months of 2001 and $650,000
for the same period in 2000. We expect similar  fluctuations to occur throughout
the  year,  as the  amount  and  frequency  of  stock-related  transactions  are
dependent upon the market performance of our common stock.

     We believe that our existing  capital  resources,  together  with  interest
income and future payments due under our strategic alliances, will be sufficient
to satisfy our current and projected funding  requirements for at least the next
12 months.  However,  we cannot  guarantee  that  these  capital  resources  and
payments will be sufficient to conduct our research and development  programs as
planned. The amount and timing of expenditures will vary depending upon a number
of factors, including progress of our research and product development programs.

     We will  require  additional  funding to continue  our research and product
development  programs,  to conduct pre-clinical studies and clinical trials, for
operating expenses,  to pursue regulatory  approvals for our product candidates,
for the costs  involved  in  filing  and  prosecuting  patent  applications  and
enforcing or defending patent claims,  if any, the cost of product  in-licensing
and  any  possible  acquisitions,  and  we may  require  additional  funding  to
establish manufacturing and marketing capabilities in the future. We may seek to
access the public or private equity markets  whenever  conditions are favorable.
We may also  seek  additional  funding  through  strategic  alliances  and other
financing  mechanisms.  We  cannot  assure  you that  adequate  funding  will be
available  on terms  acceptable  to us,  if at all.  If  adequate  funds are not
available,  we may be  required  to  curtail  significantly  one or  more of our
research or  development  programs or obtain  funds  through  arrangements  with
collaborators or others.  This may require us to relinquish rights to certain of
our technologies or product candidates.


     We expect to incur  operating  losses  over the next  several  years as our
research,  development,  pre-clinical  studies  and  clinical  trial  activities
increase.  To the extent that we are unable to obtain  third  party  funding for
such expenses, we expect that increased expenses will result in increased losses
from  operations.  We  cannot  assure  you  that we will  be  successful  in the
development  of our product  candidates,  or that, if  successful,  any products
marketed will generate sufficient revenues to enable us to earn a profit.


INTEREST RATE RISK

     We are exposed to interest rate risk on our short-term  investments  and on
our long-term  debt. The primary  objective of our  investment  activities is to
preserve   principal   while  at  the  same  time   maximizing   yields  without
significantly  increasing  risk. To achieve this objective,  we invest in highly
liquid and high quality  government and other debt  securities.  To minimize our
exposure  due to  adverse  shifts in  interest  rates,  we invest in  short-term
securities and ensure that the maximum average  maturity of our investments does
not exceed 40 months. If a 10% change in interest rates were to have occurred on
September 30, 2001, this change would not have had a material effect on the fair
value of our  investment  portfolio  as of that date.  Due to the short  holding
period of our  investments,  we have  concluded  that we do not have a  material
financial market risk exposure.

     Interest risk exposure on long-term debt relates to our note payable, which
bears a floating  interest  rate of prime  plus one  quarter  percent  (6.25% at
September  30, 2001 and 9.75% at December 31,  2000).  At September 30, 2001 and
December 31, 2000,  the note  balance was $186,000 and  $311,000,  respectively.
This note is payable in equal monthly  installments  through January 2003. Based
on the balance of our  long-term  debt,  we have  concluded  that we do not have
material financial market risk exposure.


CAUTION ON FORWARD-LOOKING STATEMENTS

     Our business is subject to significant risks, including but not limited to,
the risks  inherent in our research and  development  activities,  including the
successful  continuation  of  our  strategic   collaborations,   the  successful
completion of clinical trials,  the lengthy,  expensive and uncertain process of
seeking regulatory approvals,  uncertainties  associated both with the potential
infringement of patents and other intellectual property rights of third parties,
and  with   obtaining  and   enforcing  our  own  patents  and  patent   rights,
uncertainties   regarding   government   reforms  and  of  product  pricing  and
reimbursement  levels,  technological  change  and  competition,   manufacturing



uncertainties  and dependence on third parties.  Even if our product  candidates
appear promising at an early stage of development, they may not reach the market
for numerous reasons.  Such reasons include the  possibilities  that the product
will be  ineffective  or unsafe  during  clinical  trials,  will fail to receive
necessary  regulatory  approvals,  will be difficult to  manufacture  on a large
scale,   will  be   uneconomical   to   market   or  will  be   precluded   from
commercialization  by proprietary rights of third parties.  For more information
about the risks we face, see "Risk Factors"  included in Part I of our Form 10-K
filed with the SEC.


ITEM 3. QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK

     A discussion of the Company's  exposure to, and  management of, market risk
appears  in Part 1,  Item 2 of this  Quarterly  Report  on Form  10-Q  under the
heading "Interest Rate Risk".


                           PART II: OTHER INFORMATION

ITEM 6. EXHIBITS AND REPORTS ON FORM 8-K

(A)  Exhibits.  The following exhibit is filed as part of this report:

      10.1 Employment  Agreement dated October 17, 2001,  between the Registrant
           and Henry Pan, MD, PhD.

(B)  Reports on Form 8-K.  There were no current reports on Forms 8-K filed this
     quarter.



                                   SIGNATURES

Pursuant to the  requirements  of the  Securities  and Exchange Act of 1934, the
registrant  has  duly  caused   this  report  to be signed on its behalf  by the
undersigned thereunto duly authorized.

     Dated:   11/12/01                                 /s/ Paul W. Hawran
           ------------                            ----------------------------
                                                   Paul W. Hawran
                                                   Executive Vice President and
                                                   Chief Financial Officer




                              EMPLOYMENT AGREEMENT

EMPLOYMENT AGREEMENT, dated as of October 17, 2001 (the "Effective Date") by and
between  NEUROCRINE  BIOSCIENCES,  INC.,  10555 Science Center Drive, San Diego,
California 92121  (hereinafter the "Company"),  and Henry Pan, MD, PhD., 14 East
Shore Drive Princeton, NJ 08540 (hereinafter "Executive").

                                R E C I T A L S

     WHEREAS,  the Company and Executive wish to set forth in this Agreement the
terms and conditions  under which  Executive is to be employed by the Company on
and after the date hereof; and

     NOW, THEREFORE,  the Company and Executive,  in consideration of the mutual
promises set forth herein, agree as follows:

                                   ARTICLE 1

                               TERM OF AGREEMENT

     1.1 Commencement  Date.  Executive's  fulltime  employment with the Company
under this Agreement shall commence as of October 15, 2001 ("Commencement Date")
and this  Agreement  shall  expire  after a period of three  (3) years  from the
Commencement Date, unless terminated earlier pursuant to Article 6.

     1.2 Renewal. The term of this Agreement shall be automatically  renewed for
successive, additional three (3) year terms unless either party delivers written
notice to the other at least ninety (90) days prior to the end of any term of an
intention  to  terminate  this  Agreement or to renew it for a term of less than
three (3) years but not less  than (1) year.  If the term of this  Agreement  is
renewed  for a term of less than three (3) years,  then  thereafter  the term of
this  Agreement  shall  be  automatically  renewed  for  successive,  additional
identical terms unless either party delivers a written notice to the other of an
intention to terminate this Agreement or to renew it for a different term of not
less than one (1) year,  such notice to be  delivered  at least ninety (90) days
prior to the end of any term.  The Company's  failure to renew this Agreement at
the end of any term shall be considered a termination without Cause as set forth
in Section 6.4 below.

                                   ARTICLE 2

                               EMPLOYMENT DUTIES

     2.1  Title/Responsibilities.  Executive hereby accepts  employment with the
Company pursuant to the terms and conditions  hereof.  Executive agrees to serve
the Company in the position of Executive Vice President,  Clinical  Research and




Chief Medical Officer.  Executive shall have the powers and duties  commensurate
with such position,  including but not limited to hiring personnel  necessary to
carry out the  responsibilities  for such  position  as set forth in the  annual
business plan approved by the Board of Directors.

     2.2 Full Time  Attention.  Executive  shall devote his best efforts and his
full business time and attention to the performance of the services  customarily
incident to such office and to such other services as the President or Board may
reasonably request.

     2.3  Other  Activities.  Except  upon  the  prior  written  consent  of the
President & Chief  Executive  Officer,  Executive shall not during the period of
employment  engage,  directly  or  indirectly,  in any other  business  activity
(whether or not pursued for pecuniary  advantage)  that is or may be competitive
with, or that might place him in a competing  position to that of the Company or
any other  corporation  or entity  that  directly  or  indirectly  controls,  is
controlled  by, or is under  common  control  with the Company  (an  "Affiliated
Company"),  provided  that  Executive  may own less than two percent (2%) of the
outstanding securities of any such publicly traded competing corporation.


                                   ARTICLE 3

                                  COMPENSATION

     3.1 Base Salary. Executive shall receive a Base Salary at an annual rate of
three hundred and fifteen thousand dollars ($315,000),  payable  semi-monthly in
equal  installments in accordance with the Company's  normal payroll  practices.
The Chief  Executive  Officer shall provide  Executive  with annual  performance
reviews,  and, thereafter,  Executive shall be entitled to such increase in Base
Salary as the Chief  Executive  Officer and Board of Directors  may from time to
time establish in their sole discretion.

     3.2  Incentive  Bonus.  In  addition to any other  bonus  Executive  may be
awarded by the Company's Board of Directors,  the Company shall pay Executive an
annual  bonus as  determined  by the  Company's  Board of  Directors  and  Chief
Executive  Officer based upon achievement of Executive in meeting personal goals
approved by the Chief  Executive  Officer/ Board of Directors and achievement by
the Company of  corporate  goals  approved by the Board of  Directors  annually.
Executive's  personal goals and the Company's  corporate goals will be set forth
in writing by the Chief  Executive  Officer  and Board  within  ninety (90) days
after the start of the Company's  fiscal year.  The Board of Directors and Chief
Executive Officer shall, in their sole discretion, determine whether Executive's
personal goals have been  obtained.  The Board of Directors  shall,  in its sole
discretion, determine whether the corporate goals have been obtained.

     3.3 Equity.
      (a) Initial Grant.  Pursuant to a Consulting Agreement dated September 25,
          2001,  the Executive  was granted an option  pursuant to the Company's
          1992 Stock  Incentive  Plan,  as  amended,  to  purchase  two  hundred
          thousand  ($200,000) shares of the Company's common stock which option
          vests over a four-year period with  twenty-five  percent (25%) of such



          vesting occurring on September 25, 2002 and 1/48 per month thereafter.
          The  Executive's  Consulting  Agreement  will  be  superceded  by this
          Employment  Agreement and the stock options  granted  thereunder  will
          continue  to vest in  accordance  with the 1992 Stock  Incentive  Plan
          during the term of this Employment Agreement.
      (b) Signing  Bonus.  As  special  consideration  for  entering  into  this
          Agreement,  on the Effective  Date of this  Agreement the Company will
          sell to Executive 7500 shares of Company stock ("Signing Shares"). The
          Signing  Shares will be held by the Company as  restricted  shares not
          available  for  resale  until  such  time as the  Signing  Shares,  or
          installment  thereof as provided below, have been paid for in full and
          delivered to Executive.  Executive will purchase the Signing Shares by
          providing to Company a note for the market value of the Signing Shares
          (the  "Note").  The Note  will  bear  interest  payable  by  Executive
          annually in arrears. The principal amount of the Note will be forgiven
          in  four  (4)  equal  installments  on  each  of the  first  four  (4)
          anniversaries  of the  Effective  Date  provided  there  has  been  no
          termination of this Agreement. Upon forgiveness of each installment of
          the principal of the Note, the Signing Shares  relating  thereto shall
          be deemed paid for in full and will be delivered to Executive  free of
          restrictions. In the event this Agreement shall be terminated prior to
          the  fourth  anniversary  of  the  Effective  Date,  the  Company  may
          repurchase  the Signing Shares for the then  outstanding  principal of
          the Note.
      (c) Annual Grants. Each year for the term of this Agreement, the Executive
          will be eligible to receive a Stock Option  award under the  Company's
          1992  Incentive  Stock  Option  Plan,  as amended,  with the number of
          shares  and  exercise  price as shall be  determined  by the  Board of
          Directors.

     3.4  Withholdings.  All  compensation  and  benefits  payable to  Executive
hereunder and the Agreement  shall be subject to all federal,  state,  local and
other withholdings and similar taxes and payments required by applicable law.

                                    ARTICLE 4

                     EXPENSE ALLOWANCES AND FRINGE BENEFITS

     4.1 Vacation. Executive shall be entitled to the greater of three (3) weeks
of annual paid vacation or the amount of annual paid vacation to which Executive
may become  entitled under the terms of Company's  vacation policy for employees
during the term of this Agreement.

     4.2  Benefits.  During the term of this  Agreement,  the Company shall also
provide Executive with the usual health insurance benefits it generally provides
to its other  senior  management  employees.  As Executive  becomes  eligible in
accordance with criteria to be adopted by the Company, the Company shall provide
Executive  with the right to  participate  in and to receive  benefit from life,
accident, disability, medical, pension, bonus, stock, profit-sharing and savings
plans and similar benefits made available  generally to employees of the Company
as such plans and benefits may be adopted by the Company.  The amount and extent
of benefits to which  Executive  is entitled  shall be governed by the  specific
benefit plan as it may be amended from time to time.



     4.3  Business  Expense  Reimbursement.  During the term of this  Agreement,
Executive shall be entitled to receive proper  reimbursement  for all reasonable
out-of-pocket  expenses  incurred by him (in  accordance  with the  policies and
procedures  established  by the Company for its senior  executive  officers)  in
performing  services  hereunder.  Executive  agrees to  furnish  to the  Company
adequate  records  and other  documentary  evidence  of such  expense  for which
Executive seeks  reimbursement.  Such expenses shall be reimbursed and accounted
for under the policies and procedure established by the Company.

     4.4  Relocation  Expense.  The Company will  reimburse  the  Executive  for
reasonable and customary out of pocket expenses relating to:
      (a) Travel.  Travel  from  Princeton,  NJ to San Diego for  Executive  and
          spouse for the final  move.  If by auto,  the Company  will  reimburse
          mileage ($0.10/mile), lodging and meals.
      (b) Temporary  Housing.  Temporary  housing  in San Diego for up to twelve
          (12) months to be arranged by the Company.
      (c) Moving Household Goods. Movement and storage (up to six (6) months) of
          household goods by authorized  Company  carrier,  to be coordinated by
          the Company.
      (d) Relocation  Expenses.  Reimbursement  of  up to  twenty-five  thousand
          dollars ($25,000.00) for miscellaneous  documented relocation expenses
          payable upon the purchase or rental of a home in San Diego.
      (e) Real Estate  Commissions.  Reimbursement  of reasonable  and customary
          real estate  commission  and closing costs on the sale of  Executive's
          home in Princeton;
      (f) Taxes.  The Company will reimburse the Executive for federal and state
          income taxes  associated  with items (a) through (e), except for those
          expenses  which  are  deductible  for  federal  and state  income  tax
          purposes.  In addition the company will retain, at company expense,  a
          tax  specialist  who will  provide tax guidance  associated  with your
          relocation for up to three years.


     4.5 Home Loan. In connection with Executive's purchase of a home in the San
Diego area,  the Company  will provide to Executive a loan of up to four hundred
thousand dollars ($400,000) repayable in full upon the first to occur of (a) the
four (4) year  anniversary of the loan, (b) termination of this  Agreement,  (c)
sale of by Executive of any NBI security,  or (d) refinancing or sale of the San
Diego  home.  The loan will bear  interest  at a rate of five  percent (5% p.a.)
payable  annually in arrears and will be secured with a second  mortgage deed on
the San Diego  home.  For so long as the loan  remains  outstanding,  twelve and
one-half percent (12.5%) of the outstanding principal amount of the loan will be
forgiven on each of the first four  anniversaries  of the date of the loan for a
total  forgiveness of fifty percent  (50%).  It shall be a condition of the loan
that Executive shall have provided a down payment on purchase of the home in San
Diego of at least ten percent (10%) excluding the proceeds of the Company loan.



     4.6 Purchase of San Diego Home.
      (a) Points. The Company will reimburse Executive up to three (3) points of
          the principal  balance of the Executive's new mortgage relating to the
          purchase of a home in the San Diego area.
      (b) Mortgage  Equalization.  In connection  with the purchase of a home in
          the San Diego area,  for a period of three (3) years the Company  will
          provide to Executive  annual  mortgage  equalization  payments for the
          amount by which the purchase  price of the San Diego area home exceeds
          the selling  price of  Executive's  New Jersey home up to a maximum of
          three hundred thousand dollars ($300,000).  The equalization  payments
          will  be a  percentage  of the  incremental  interest  to be  paid  by
          Executive by reason of the amount by which the  purchase  price of the
          San Diego home exceeds the selling price of the Executive's New Jersey
          home (up to three  hundred  thousand  dollars  $300,000).  Such annual
          equalization payments will be as follows from the date of purchase and
          payable  semi-monthly  (i) Year One - one  hundred  percent  (100%) of
          incremental  interest;  (ii)  Year Two - sixty  six  percent  (66%) of
          incremental  interest;  (iii)  Year  Three -  thirty  three  (33%)  of
          incremental interest.
      (c) Interest  Reimbursement.  If  Executive  purchases a home in San Diego
          before he has sold his New Jersey  home,  the Company  will  reimburse
          Executive for the lesser of the his mortgage  interest  payment on his
          New Jersey  home and his  mortgage  interest  payment on his San Diego
          home (after taking into consideration  payments under Sections 4.5 and
          4.6  hereof),  provided,  Company  is not at that time also  providing
          Executive with temporary  housing in San Diego and,  provided further,
          that such reimbursement will only be provided for the period beginning
          on the  Effective  Date of this  Agreement  and ending on the one year
          anniversary  thereof.  Thereafter,  at such time as Executive's spouse
          relocates  from New  Jersey to San Diego and in  connection  therewith
          Executive's  New Jersey  home is listed  for sale,  the  Company  will
          reimburse  Executive  for  the  lesser  of the his  mortgage  interest
          payment on his New Jersey home and his  mortgage  interest  payment on
          his San Diego home (after  taking into  consideration  payments  under
          Sections  4.5 and 4.6  hereof)  for a  period  not to  exceed  six (6)
          months.

     4.7 Personal Travel. For the first twelve (12) months of this Agreement the
Company will provide to Executive one round trip Coach Class airline  ticket San
Diego- New Jersey per month for  Executive's  personal  travel and,  during such
twelve  (12) month  period,  up to six (6)  additional  round  trip Coach  Class
airline tickets San Diego- New Jersey for Executive's spouse. These tickets will
be booked  through the Company's  corporate  travel account and the Company will
provide Business Class upgrades for such tickets on an as available basis.

     4.8 Taxes. Executive will be responsible for the payment of all federal and
state income taxes on all  allowances,  loans and loan  forgiveness  accruing to
Executive pursuant to this Article 4.




                                    ARTICLE 5

                                 CONFIDENTIALITY

     5.1 Proprietary Information.  Executive represents and warrants that he has
previously  executed  and  delivered  to  the  Company  the  Company's  standard
Proprietary  Information  and  Inventions  Agreement in form  acceptable  to the
Company's counsel.

     5.2 Return of Property. All documents,  records,  apparatus,  equipment and
other  physical  property  which is furnished to or obtained by Executive in the
course of his employment  with the Company shall be and remain the sole property
of the Company.  Executive  agrees that, upon the termination of his employment,
he shall  return all such  property  (whether or not it pertains to  Proprietary
Information as defined in the Proprietary Information and Inventions Agreement),
and agrees not to make or retain copies,  reproductions or summaries of any such
property.

     5.3  No  use  of  Prior  Confidential   Information.   Executive  will  not
intentionally  disclose  to the  Company or use on its  behalf any  confidential
information belonging to any of his former employers or any other third party.


                                    ARTICLE 6

                                   TERMINATION

     6.1 By Death. The period of employment shall terminate  automatically  upon
the death of  Executive.  In such event,  all stock options held by Executive at
the time of  termination  will  continue  to vest for a period of six (6) months
following  termination.  All stock options held by Executive  that are vested at
the time of termination or within six (6) months  thereafter will be exercisable
in  accordance  with  their  terms  for a for a  period  of one  year  following
termination.  In addition, the Company shall pay to Executive's beneficiaries or
his estate, as the case may be, any accrued Base Salary,  any bonus compensation
to the extent earned, any vested deferred  compensation (other than pension plan
or  profit-sharing  plan  benefits  which  will be paid in  accordance  with the
applicable plan), any benefits under any plans of the Company in which Executive
is a participant to the full extent of Executive's  rights under such plans, any
accrued vacation pay and any appropriate business expenses incurred by Executive
in  connection  with  his  duties  hereunder,  all to the  date  of  termination
(collectively Accrued Compensation),  but no other compensation or reimbursement
of  any  kind,  including,  without  limitation,   severance  compensation,  and
thereafter, the Company's obligations hereunder shall terminate.

     6.2 By Disability.  If Executive is prevented from properly  performing his
duties hereunder by reason of any physical or mental  incapacity for a period of
120  consecutive  days, or for 180 days in the aggregate in any 365-day  period,
then, to the extent  permitted by law, the Company may terminate the  employment
of Executive at such time. In such event, all stock options held by Executive at
the time of  termination  will  continue  to vest for a period of six (6) months



following  termination.  All stock options held by Executive  that are vested at
the time of termination or within six (6) months  thereafter will be exercisable
in  accordance  with  their  terms  for a for a  period  of one  year  following
termination.  In  addition,  the  Company  shall pay to  Executive  all  Accrued
Compensation,  and shall continue to pay to Executive the Base Salary until such
time),  as  Executive  shall  become  entitled to receive  disability  insurance
payments under the disability insurance policy maintained by the Company, but no
other compensation or reimbursement of any kind,  including without  limitation,
severance compensation, and thereafter the Company's obligations hereunder shall
terminate.  Nothing in this Section  shall affect  Executive's  rights under any
disability plan in which he is a participant.

     6.3 By  Company  for Cause.  The  Company  may  terminate  the  Executive's
employment for Cause (as defined  below)  without  liability at any time with or
without advance notice to Executive. The Company shall pay Executive all Accrued
Compensation,  but no other compensation or reimbursement of any kind, including
without  limitation,   severance  compensation,  and  thereafter  the  Company's
obligations  hereunder shall terminate.  Termination shall be for "Cause" in the
event of the occurrence of any of the following:  (a) any intentional  action or
intentional  failure to act by Executive which was performed in bad faith and to
the material detriment of the Company;  (b) Executive  intentionally  refuses or
intentionally fails to act in accordance with any lawful and proper direction or
order of the Chief Executive Officer;  (c) Executive and habitually neglects the
duties of employment;  or (d) Executive is convicted of a felony crime involving
moral  turpitude,  provided that in the event that an of the foregoing events is
capable of being cured,  the Company shall provide  written  notice to Executive
describing the nature of such event and Executive shall thereafter have ten (10)
business days to cure such event.

     6.4  Termination  Without Cause. At any time, the Company may terminate the
employment of Executive without liability other than as set forth below, for any
reason not  specified in Section 6.3 above,  by giving  thirty (30) days advance
written  notice to  Executive.  If the  Company  elects to  terminate  Executive
pursuant to this Section 6.4,
      (a) the Company shall pay to Executive all Accrued Compensation,
      (b) the Company  shall  continue to pay to  Executive  as provided  herein
          Executive's  Base Salary over the period equal to nine (9) months from
          the date of such termination as severance compensation,
      (c) the Company  shall make a lump sum payment to  Executive  in an amount
          equal to a pro rata  portion of the  Executive's  annual  actual  cash
          incentive  bonus  for  Company's  fiscal  year  preceding  the year of
          termination  based on the number of  completed  months of  Executive's
          employment in the fiscal year plus nine (9),
      (d) the vesting of all  outstanding  stock options held by Executive shall
          be  accelerated  so that the amount of shares vested under such option
          shall equal that number of shares  which would have been vested if the
          Executive had continued to render services to the Company for nine (9)
          continuous months after the date of his termination of employment, and
      (e) the Company shall pay all costs which the Company would otherwise have
          incurred  to  maintain  all of  Executive's  health and  welfare,  and
          retirement  benefits (either on the same or  substantially  equivalent



          terms  and  conditions)  if the  Executive  had  continued  to  render
          services to the Company for nine (9) continuous  months after the date
          of his  termination of  employment.  The Company shall have no further
          obligations  to Executive  other than those set forth in the preceding
          sentence.  During the period when such severance compensation is being
          paid to  Executive,  Executive  shall  not  (i)  engage,  directly  or
          indirectly,  in providing  services to any other  business  program or
          project that is competitive to a program or project being conducted by
          the Company or any Affiliated  Company at the time of such  employment
          termination  (provided  that  Executive  may own less than two percent
          (2%)  of  the   outstanding   securities   of  any   publicly   traded
          corporation),  or (ii) hire,  solicit, or attempt to solicit on behalf
          of himself or any other party or any employee or exclusive  consultant
          of the  Company.  If the  Company  terminates  this  Agreement  or the
          employment  of  Executive  with the  Company  other than  pursuant  to
          Section 6.1, 6.2 or 6.3, then this section 6.4 shall apply.

     6.5 Constructive Termination. A Constructive Termination shall be deemed to
be a termination  of employment of Executive  without cause  pursuant to Section
6.4. For Purposes of this Agreement, a "Constructive Termination" means that the
Executive  voluntarily  terminates his employment  except in connection with the
termination  of  his  employment  for  death,  disability,   retirement,  fraud,
misappropriation,  embezzlement  (or  any  other  occurrence  which  constitutes
"Cause" under section 6.3) or any other  voluntary  termination of employment by
Executive other than a Constructive  Termination  after any of the following are
undertaken without Executive's express written consent:
      (a) the  assignment to Executive of any duties or  responsibilities  which
          result in any  diminution of position as judged against the duties and
          responsibilities  assigned to executives with Executive's  position in
          the Company's peer group of companies and shall not include (i) duties
          and responsibilities assigned to Executive with the understanding that
          as the Company grows and management  staff  increases in number,  such
          duties and responsibilities  will eventually be reassigned in a manner
          consistent with the Company's peer group of companies,  (ii) change in
          reporting  relationship  that does not change in any  material way the
          Executive's duties and  responsibilities or (iii) any change in duties
          or responsibilities or reporting relationships that Executive does not
          identify as Constructive Termination to the Chief Executive Officer in
          writing  within  15  days  following  the  Chief  Executive  Officer's
          proposal of such change to Executive;
      (b) a  reduction  by the  Company in  Executive's  annual  Base  Salary by
          greater than five percent (5%);
      (c) a relocation of Executive or the Company's principal executive offices
          if Executive's principal office is at such offices, to a location more
          than forty (40) miles from the  location  at which  Executive  is then
          performing his duties,  except for an opportunity to relocate which is
          accepted by Executive in writing;
      (d) any material breach by the Company of any provision of this Agreement;
          or



      (e) any failure by the Company to obtain the  assumption of this Agreement
          by any successor or assign of the Company.

     6.6 Termination  Following Change in Control. Upon a Change in Control, the
Company shall pay to Executive a lump sum  severance  payment in an amount equal
to one (1.0)  times  (Executive's  then Base  Salary  plus  annual  actual  cash
incentive  bonus for Company's  fiscal year  preceding the year of  termination)
plus  reimbursement  for federal and state income taxes  payable by Executive by
reason  of  the  such  severance  payment.  In  addition,  the  vesting  of  all
outstanding  stock options held by Executive  shall be  accelerated  so that the
options are immediately exercisable in full.

     6.7  Change in  Control.  For  purposes  of this  Agreement,  a "Change  in
Control"  shall have  occurred  if at any time  during  the term of  Executive's
employment hereunder, any of the following events shall occur:
      (a) The Company is merged,  or  consolidated.  or reorganized into or with
          another  corporation  or other legal  person,  and as a result of such
          merger,  consolidation or reorganization less than 50% of the combined
          voting power of the then-outstanding securities of such corporation or
          person immediately after such transaction are held in the aggregate by
          the holders of voting  securities of the Company  immediately prior to
          such transaction;
      (b) The Company sells all or substantially  all of its assets or any other
          corporation or other legal person and thereafter, less than 50% of the
          combined voting power of the then-outstanding voting securities of the
          acquiring  or  consolidated  entity are held in the  aggregate  by the
          holders of voting securities of the Company  immediately prior to such
          sale;
      (c) There is a report  filed after the date of this  Agreement on Schedule
          13 D or schedule 14 D-1 (or any successor  schedule,  form or report),
          each as promulgated  pursuant to the  Securities  Exchange Act of l934
          (the "Exchange Act")  disclosing that any person (as the term "person"
          is used in Section  13(d)(3) or Section  14(d)(2) of the exchange Act)
          has  become  the  beneficial  owner (as the term  beneficial  owner is
          defined  under  Rule  13d-3  or  any  successor   rule  or  regulation
          promulgated  under the Exchange Act)  representing  50% or more of the
          combined voting power of the then-outstanding voting securities of the
          Company;
      (d) The Company shall file a report or proxy statement with the Securities
          and Exchange  Commission  pursuant to the Exchange Act  disclosing  in
          response to item 1 of Form 8-X  thereunder or Item 5(f) of Schedule 14
          A  thereunder  (or any  successor  schedule,  form or  report  or item
          therein)  that the change in control  of the  Company  has or may have
          occurred  or  will  or  may  occur  in  the  future  pursuant  to  any
          then-existing contract or transaction; or
      (e) During any period of two (2) consecutive years, individuals who at the
          beginning of any such period  constitute  the directors of the Company



          cease for any reason to constitute at least a majority  thereof unless
          the  election  to  the   nomination  for  election  by  the  Company's
          shareholders of each director of the Company first elected during such
          period was approved by a vote of at least  two-thirds of the directors
          of the Company then still in office who were  directors of the Company
          at the beginning of such period.

     6.8  Termination  by  Executive.  At any time,  Executive may terminate his
employment by giving thirty (30) days advance written notice to the Company. The
Company shall pay Executive all Accrued Compensation,  but no other compensation
or  reimbursement  of  any  kind,   including  without   limitation,   severance
compensation,   and  thereafter  the  Company's   obligations   hereunder  shall
terminate.

     6.9 Mitigation. Except as otherwise specifically provided herein, Executive
shall not be required to mitigate the amount of any payment  provided under this
Agreement by seeking other employment or  self-employment,  nor shall the amount
of any payment  provided for under this Agreement be reduced by any compensation
earned by Executive  as a result of  employment  by another  employer or through
self-employment  or  by  retirement  benefits  after  the  date  of  Executive's
termination of employment from the Company.

     6.10  Coordination.  If upon termination of employment,  Executive  becomes
entitled to rights under other plans,  contracts or arrangements entered into by
the Company, this Agreement shall be coordinated with such other arrangements so
that  Executive's  rights under this  Agreement  are not  reduced,  and that any
payments  under  this  Agreement  offset the same  types of  payments  otherwise
provided under such other arrangements, but do not otherwise reduce any payments
or benefits under such other arrangements to which Executive becomes entitled.


                                    ARTICLE 7

                               GENERAL PROVISIONS

     7.1  Governing  Law.  The  validity,   interpretation,   construction   and
performance of this Agreement and the rights of the parties  thereunder shall be
interpreted and enforced under California law without reference to principles of
conflicts of laws.  The parties  expressly  agree that inasmuch as the Company's
headquarters  and principal  place of business are located in California,  it is
appropriate that California law govern this Agreement.

     7.2 Assignment; Successors Binding Agreement.
      (a) Executive  may not  assign,  pledge or encumber  his  interest in this
          Agreement or any part thereof.
      (b) The Company will require any successor (whether direct or indirect, by
          purchase, merger,  consolidation or otherwise) to all or substantially
          all of the business and/or assets of the Company,  by operation of law



          or by  agreement  in form and  substance  reasonably  satisfactory  to
          Executive,  to assume and agree to perform this  Agreement in the same
          manner and to the same extent  that the  Company  would be required to
          perform it if no such succession had taken place.
      (c) This  Agreement  shall inure to the benefit of and be  enforceable  by
          Executive's    personal   or   legal    representatives,    executors,
          administrators, successors, heirs, distributee, devisees and legatees.
          If  Executive  should die while any amount is at such time  payable to
          his hereunder,  all such amounts,  unless  otherwise  provided herein,
          shall be paid in  accordance  with  the  terms  of this  Agreement  to
          Executive's devisee, legates or other designee or, if there be no such
          designee, to his estate.

     7.3 Certain Reduction of Payments. In the event that any payment or benefit
received or to be received by Executive under this Agreement would result in all
or a  portion  of such  payment  to be  subject  to the  excise  tax on  "golden
parachute  payments" under Section 4999 of the Internal Revenue Code of 1986, as
amended (the  "Code"),  then  Executive's  payment  shall be either (a) the full
payment  or (b) such  lesser  amount  which  would  result in no  portion of the
payment being subject to excise tax under Section 4999 of the Code, whichever of
the foregoing  amounts,  taking into account the applicable  Federal,  state and
local employment taxes, income taxes, and the excise tax imposed by Section 4999
of the Code,  results in the receipt by Executive on an after-tax  basis, of the
greatest amount of the payment  notwithstanding  that all or some portion of the
payment may be taxable under Section 4999 of the Code.

     7.4  Notice.  For the  purposes  of this  Agreement,  notices and all other
communications  provided for in this Agreement  shall be in writing and shall be
deemed  to have been duly  given  when  delivered  or  mailed  by  certified  or
registered mail,  return receipt  requested,  postage prepaid,  addressed to the
respective  addresses  set forth below or to such other  address as either party
may have furnished to the other in writing in accordance  herewith,  except that
notice of change of address shall be effective only upon receipt.

     To the Company:
      Neurocrine Biosciences, Inc.
      10555 Science Center Drive
      San Diego, CA 92121
      Attn.: President & Chief Executive Officer

     To Executive:
      Henry Pan, M.D.
      14 East Shore Drive
      Princeton, New Jersey 08540

     7.5 Modification; Waiver; Entire Agreement. No provisions of this Agreement
may be  modified,  waived or  discharged  unless such  waiver,  modification  or
discharge is agreed to in writing signed by Executive and such officer as may be
specifically  designated by the Board of the Company.  No waiver by either party



hereto at any time of any breach by the other party of, or compliance  with, any
condition  or  provision  of this  Agreement to be performed by such other party
shall be deemed a waiver of similar or  dissimilar  provisions  or conditions at
the same or any prior or subsequent time. No agreements or representations, oral
or otherwise, express or implied, with respect to the subject matter hereof have
been made by either party which are not expressly set forth in this Agreement.

     7.6 Validity.  The invalidity or  unenforceability of any provision of this
Agreement shall not affect the validity or enforceability of any other provision
of this Agreement, which shall remain in full force and effect.

     7.7 Controlling  Document.  Except to the extent described in Section 6.l0,
in case of conflict between any of the terms and condition of this Agreement and
the document  herein  referred to, the terms and  conditions  of this  Agreement
shall control.

     7.8  Executive  Acknowledgment.  Executive  acknowledges  (a)  that  he has
consulted with or has had the opportunity to consult with independent counsel of
his own choice  concerning this Agreement,  and has been advised to do so by the
Company, and (b) that he has read and understands the Agreement,  is fully aware
of its legal effect, and has entered into it freely based on his own judgment.

     7.9 Remedies.
      (a) Injunctive  Relief. The parties agree that the services to be rendered
          by Executive hereunder are of a unique nature and that in the event of
          any  breach or  threatened  breach of any of the  covenants  contained
          herein, the damage or imminent damage to the value and the goodwill of
          the Company's business will be irreparable and extremely  difficult to
          estimate,   making  any  remedy  at  law  or  in  damages  inadequate.
          Accordingly,  the parties  agree that the Company shall be entitled to
          injunctive  relief  against  Executive  in the event of any  breach or
          threatened breach of any such provisions by Executive,  in addition to
          any other relief  (including  damage)  available to the Company  under
          this Agreement or under law.
      (b) Exclusive.  Both  parties  agree that the remedy  specified in Section
          7.9.1  above is not  exclusive  of any other  remedy for the breach by
          Executive of the terms hereof.

     7.10  Counterparts.   This  Agreement  may  be  executed  in  one  or  more
counterparts,  all of which taken  together  shall  constitute  one and the same
Agreement.

     7.11 Prevailing Party Expenses.  In the event that any action or proceeding
is commenced to enforce the provisions of the Agreement,  the court adjudicating
such  action or  proceeding  shall award to the  prevailing  party all costs and
expenses thereof, including, but not limited to, all reasonable attorneys' fees,
court costs, and all other related expenses.



Executed by the parties as of the day and year first above written.

      EXECUTIVE                              NEUROCRINE BIOSCIENCES, INC

      By: \s\ Henry Pan                       By: \s\ Gary A. Lyons
          -----------------------                 -----------------------
          Henry Pan, M.D.,Ph.D.                   Gary A. Lyons