AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON MAY 23, 1996 
 
                                                     REGISTRATION NO. 333-
- -------------------------------------------------------------------------------
- -------------------------------------------------------------------------------
                      SECURITIES AND EXCHANGE COMMISSION
                            WASHINGTON, D.C. 20549
                               ---------------
                            REGISTRATION STATEMENT
                                     UNDER
                          THE SECURITIES ACT OF 1933
                               ---------------
                         NEUROCRINE BIOSCIENCES, INC.
            (EXACT NAME OF REGISTRANT AS SPECIFIED IN ITS CHARTER)
                               ---------------
        DELAWARE                     8731                   33-0525145
     (STATE OR OTHER     (PRIMARY STANDARD INDUSTRIAL   (I.R.S. EMPLOYER
     JURISDICTION OF     CLASSIFICATION CODE NUMBER)   IDENTIFICATION NO.)
    INCORPORATION OR
      ORGANIZATION)
                               ---------------
                            3050 SCIENCE PARK ROAD
                          SAN DIEGO, CALIFORNIA 92121
                                (619) 658-7600
  (ADDRESS, INCLUDING ZIP CODE, AND TELEPHONE NUMBER, INCLUDING AREA CODE, OF
                   REGISTRANT'S PRINCIPAL EXECUTIVE OFFICES)
                               ---------------
                                 GARY A. LYONS
                     PRESIDENT AND CHIEF EXECUTIVE OFFICER
                         NEUROCRINE BIOSCIENCES, INC.
                            3050 SCIENCE PARK ROAD
                          SAN DIEGO, CALIFORNIA 92121
                                (619) 658-7600
(NAME, ADDRESS, INCLUDING ZIP CODE, AND TELEPHONE NUMBER, INCLUDING AREA CODE,
                             OF AGENT FOR SERVICE)
                               ---------------
                                  COPIES TO:
      MICHAEL J. O'DONNELL, ESQ.               ALAN C. MENDELSON, ESQ.
   WILSON SONSINI GOODRICH & ROSATI            FREDERICK T. MUTO, ESQ.
       PROFESSIONAL CORPORATION        COOLEY GODWARD CASTRO HUDDLESON & TATUM
          650 PAGE MILL ROAD                    FIVE PALO ALTO SQUARE           
   PALO ALTO, CALIFORNIA 94304-1050              3000 EL CAMINO REAL        
            (415) 493-9300                PALO ALTO, CALIFORNIA 94306-2155  
                                                     (415) 843-5000          
                               ---------------     
  APPROXIMATE DATE OF COMMENCEMENT OF PROPOSED SALE TO THE PUBLIC: As soon as
practicable after the effective date of this Registration Statement.
  If any of the securities being registered on this Form are to be offered on
a delayed or continuous basis pursuant to Rule 415 under the Securities Act of
1933, check the following box. [_]
  If this Form is filed to register additional securities for an offering
pursuant to Rule 462(b) under the Securities Act, please check the following
box and list the Securities Act registration statement number of the earlier
effective registration statement for the same offering. [X] 333-03172
  If this Form is a post-effective amendment filed pursuant to Rule 462(c)
under the Securities Act, check the following box and list the Securities Act
registration number of the earlier effective registration statement for the
same offering. [_]
  If delivery of the prospectus is expected to be made pursuant to Rule 434,
please check the following box. [_]

CALCULATION OF REGISTRATION FEE ===================================================================================================================== Proposed Proposed Maximum Maximum Title of Each Class of Securities Amount to be Offering Price Aggregate Amount of to be Registered Registered(1) Per Share(2) Offering Price(2) Registration Fee - --------------------------------------------------------------------------------------------------------------------- Common Stock, $0.001 par value... 575,000 $10.50 $6,037,500 2,082 =====================================================================================================================
(1) Includes 75,000 shares which the Underwriters have the option to purchase solely to cover over-allotments, if any. (2) Estimated solely for the purpose of computing the amount of the registration fee in accordance with Rule 457(a) under the Securities Act of 1933. -------------------------- THE REGISTRANT HEREBY AMENDS THIS REGISTRATION STATEMENT ON SUCH DATE OR DATES AS MAY BE NECESSARY TO DELAY ITS EFFECTIVE DATE UNTIL THE REGISTRANT SHALL FILE A FURTHER AMENDMENT WHICH SPECIFICALLY STATES THAT THIS REGISTRATION STATEMENT SHALL THEREAFTER BECOME EFFECTIVE IN ACCORDANCE WITH SECTION 8(a) OF THE SECURITIES ACT OF 1933 OR UNTIL THE REGISTRATION STATEMENT SHALL BECOME EFFECTIVE ON SUCH DATE AS THE COMMISSION, ACTING PURSUANT TO SAID SECTION 8(a) MAY DETERMINE. - ------------------------------------------------------------------------------- - ------------------------------------------------------------------------------- EXPLANATORY NOTE Incorporated by reference herein is, in its entirety, the Registration Statement on Form S-1 (File No. 333-03172) of Neurocrine Biosciences, Inc., which was declared effective by the Securities and Exchange Commission on May 22, 1996. SIGNATURES Pursuant to the requirements of the Act, the Registrant has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of San Diego, State of California, on the 22nd day of May, 1996. NEUROCRINE BIOSCIENCES, INC. By: /s/ Gary A. Lyons ---------------------------------- Gary A. Lyons President and Chief Executive Officer POWER OF ATTORNEY KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints, jointly and severally, Gary A. Lyons and Paul W. Hawran, C.P.A., and each one of them, individually and without the other, his attorney-in-fact, each with the power of substitution, for him in any and all capacities, to sign any and all amendments to this Registration Statement (including post effective amendments), and to file the same, with exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, hereby ratifying and confirming all that each of said attorneys-in-fact, or his substitute or substitutes, may do or cause to be done by virtue hereof. Pursuant to the requirements of the Act, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.
SIGNATURE TITLE DATE --------- ----- ---- /s/ Gary A. Lyons President, Chief Executive May 22, 1996 ____________________________________ Officer and Director Gary A. Lyons (Principal Executive Officer) /s/ Paul W. Hawran Senior Vice President and Chief May 22, 1996 ____________________________________ Financial Officer (Principal Paul W. Hawran Financial and Accounting Officer) /s/ Harry F. Hixson, Jr., Ph.D. Director May 22, 1996 ____________________________________ Harry F. Hixson, Jr., Ph.D. /s/ Howard Birndorf Director May 22, 1996 ____________________________________ Howard Birndorf /s/ David Robinson Director May 22, 1996 ____________________________________ David Robinson /s/ David Schnell, M.D. Director May 22, 1996 ____________________________________ David Schnell, M.D. /s/ Wylie W. Vale, Ph.D. Director May 22, 1996 ____________________________________ Wylie W. Vale, Ph.D.
II-1 EXHIBIT INDEX
SEQUENTIALLY EXHIBIT NUMBERED NUMBER EXHIBIT DESCRIPTION PAGE - ------- ------------------- ------------ 5.1 Opinion of Wilson, Sonsini, Goodrich & Rosati................................ 23.1 Consent of Ernst & Young LLP. Independent Auditors........................... 23.2 Consent of Wilson, Sonsini, Goodrich & Rosati (included in Exhibit 5.1)...... 24.1 Power of Attorney Included in Signature Page................................. - ------------------------


               [LETTERHEAD OF WILSON SONSINI GOODRICH & ROSATI]
 
                                                                     EXHIBIT 5.1

                                  May 22, 1996


Neurocrine Biosciences, Inc.
3050 Science Park Road
San Diego, California 92121-1102

     RE: 462(b) REGISTRATION STATEMENT ON FORM S-1

Ladies and Gentlemen:

     We have examined the Registration Statement on Form S-1 which is being 
filed with the Securities and Exchange Commission (the "Registration 
Statement"), in connection with the registration under the Securities Act of 
1933, as amended, of 575,000 shares of your Common Stock (the "Shares"), all 
of which are authorized but heretofore unissued.  The Shares are to be sold to 
the underwriters for resale to the public as described in the Registration 
Statement and pursuant to the Underwriting Agreement being filed as an exhibit 
thereto.  As your counsel, we have examined the proceedings proposed to be 
taken in connection with said sale and issuance of the Shares.

     It is our opinion that, upon completion of the proceedings being taken or
contemplated by us, as your counsel, to be taken prior to the issuance of
Shares, and upon completion of the proceedings being taken in order to permit
such transactions to be carried out in accordance with the securities laws of
the various states, where required, the Shares, when issued and sold in the
manner referred to in the Registration Statement will be legally and validly
issued, fully paid and nonassessable.

     We consent to the use of this opinion as an exhibit to the Registration 
Statement, and further consent to the use of our name wherever appearing in the 
Registration Statement, including the Prospectus constituting a part thereof, 
and any amendment thereto.

                                      Very truly yours,
                             
                                      /s/ Wilson Sonsini Goodrich & Rosati

                                      WILSON SONSINI GOODRICH & ROSATI
                                      Professional Corporation

 
                                                                   EXHIBIT 23.1
 
              CONSENT OF ERNST & YOUNG LLP, INDEPENDENT AUDITORS
 
The Board of Directors and Stockholders
Neurocrine Biosciences, Inc.

     We consent to the reference to our firm under the captions "Experts" and
"Selected Financial Data" and to the use of our reports dated February 9, 1996,
except for Note 8, as to which the date is March 29, 1996, with respect to
Neurocrine Biosciences, Inc., and April 3, 1996, with respect to Neuroscience
Pharma (NPI) Inc., in the Registration Statement (Form S-1 dated May 23, 1996)
and related Prospectus of Neurocrine Biosciences, Inc. for the registration of
575,000 shares of its common stock.

                                         ERNST & YOUNG LLP
 
San Diego, California
May 22, 1996