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                       SECURITIES AND EXCHANGE COMMISSION

                             WASHINGTON, D.C. 20549

                              ---------------------


                                    FORM 8-K

                              ---------------------


                                 CURRENT REPORT

                     Pursuant to Section 13 or 15(d) of the

                         Securities Exchange Act of 1934

     Date of Report (Date of the earliest event reported): January 14, 2002


                          NEUROCRINE BIOSCIENCES, INC.
             (Exact name of registrant as specified in its charter)


          DELAWARE                      0-28150                33-0525145
 (STATE OR OTHER JURISDICTION    (COMMISSION FILE NUMBER)    (I.R.S. EMPLOYER
       OF INCORPORATION)                                     IDENTIFICATION NO.)


                 10555 SCIENCE CENTER DRIVE, SAN DIEGO, CA 92121
               (Address of principal executive offices) (Zip Code)

       Registrant's telephone number, including area code: (858) 658-7600



                                       N/A

              (Former name or former address, if changed since last
                                    report.)

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     This Current Report on Form 8-K is filed by Neurocrine Biosciences, Inc., a
Delaware  corporation (the "Company"),  in connection with the matters described
herein.


ITEM 5.  OTHER EVENTS

     On January 11,  2002,  the Company  announced  that its Board of  Directors
approved an  amendment  of its  shareholder  rights plan to increase the initial
exercise price of the rights issued  pursuant to the plan from $51.75 to $350.00
per right.

     The intent of the increase is to preserve the  effectiveness of the plan in
view  of the  recent  appreciation  of  the  company's  stock  price.  No  other
amendments  were made to the plan.  The  shareholder  rights plan was originally
approved in April 1997. The Company was advised by Robertson Stephens, Inc.

ITEM 7.  EXHIBITS

     (a)  Exhibits. The following exhibits are filed herewith:

           Exhibit
           Number     Description of Exhibit
           ------     ----------------------
             4.1      Amended and Restated Preferred Shares Rights Agreement
            99.1      Press Release dated January 11, 2002



                                   SIGNATURES

     Pursuant to the  requirements  of the  Securities and Exchange Act of 1934,
the  registrant  has duly  caused  this report to be signed on its behalf by the
undersigned thereunto duly authorized.

Date: January 14, 2002                     NEUROCRINE BIOSCIENCES, Inc.



                                   By:     /s/ PAUL W. HAWRAN
                                           -----------------------------------
                                           Paul W. Hawran
                                           Executive Vice President and
                                           Chief Financial Officer


                          NEUROCRINE BIOSCIENCES, INC.
                                       AND
                             AMERICAN STOCK TRANSFER
                                 & TRUST COMPANY
                                  RIGHTS AGENT
                              AMENDED AND RESTATED
                        PREFERRED SHARES RIGHTS AGREEMENT
                          DATED AS OF JANUARY 11, 2002




                                TABLE OF CONTENTS

                                                                         PAGE

Section 1.     Certain Definitions                                        -1-

Section 2.     Appointment of Rights Agent                                -7-

Section 3.     Issuance of Rights Certificates                            -7-

Section 4.     Form of Rights Certificates                                -9-

Section 5.     Countersignature and Registration                         -10-

Section 6.     Transfer, Split Up, Combination and Exchange
               of Rights Certificates; Mutilated, Destroyed,
               Lost or Stolen Rights Certificates                        -11-

Section 7.     Exercise of Rights; Exercise Price;
               Expiration Date of Rights                                 -11-

Section 8.     Cancellation and Destruction of Rights Certificates       -13-

Section 9.     Reservation and Availability of Preferred Shares          -14-

Section 10.    Record Date                                               -15-

Section 11.    Adjustment of Exercise Price, Number of
               Shares or Number of Rights                                -15-

Section 12.    Certificate of Adjusted Exercise Price or
               Number of Shares                                          -22-

Section 13.    Consolidation, Merger or Sale or Transfer of
               Assets or Earning Power                                   -22-

Section 14.    Fractional Rights and Fractional Shares                   -26-

Section 15.    Rights of Action                                          -27-

Section 16.    Agreement of Rights Holders                               -28-

Section 17.    Rights Certificate Holder Not Deemed a Stockholder        -28-

Section 18.    Concerning the Rights Agent                               -28-

Section 19.    Merger or Consolidation or Change of Name of
               Rights Agent                                              -29-

Section 20.    Duties of Rights Agent                                    -29-

Section 21.    Change of Rights Agent                                    -31-

Section 22.    Issuance of New Rights Certificates                       -32-

Section 23.    Redemption                                                -33-

Section 24.    Exchange                                                  -33-

Section 25.    Notice of Certain Events                                  -35-

Section 26.    Notices                                                   -35-

Section 27.    Supplements and Amendments                                -36-


Section 28.    Successors                                                -37-

Section 29.    Determinations and Actions by the
               Board of Directors, etc.                                  -37-

Section 30.    Benefits of this Agreement                                -37-

Section 31.    Severability                                              -37-

Section 32.    Governing Law                                             -38-

Section 33.    Counterparts                                              -38-

Section 34.    Descriptive Headings                                      -38-



                                 EXHIBITS

Exhibit A      Form of Certificate of Designation

Exhibit B      Form of Rights Certificate

Exhibit C      Summary of Rights





                              AMENDED AND RESTATED

                                RIGHTS AGREEMENT

     Amended and Restated Rights Agreement, dated as of January 11, 2002, by and
between NEUROCRINE BIOSCIENCES, INC., a Delaware corporation, and American Stock
Transfer & Trust  Company (the  "Agreement"),  amending and restating the Rights
Agreement,  dated as of May 27, 1997 as amended  July 19,  1999,  by and between
NEUROCRINE  BIOSCIENCES,  INC.,  a  Delaware  corporation,  and  American  Stock
Transfer & Trust Company.

     On April 10, 1997 (the "RIGHTS DIVIDEND  DECLARATION  DATE"),  the Board of
Directors of the Company (the "Board of  Directors")  authorized  and declared a
dividend of one Preferred Share Purchase Right (a "RIGHT") for each Common Share
(as hereinafter  defined) of the Company outstanding as of the Close of Business
(as  hereinafter  defined)  on June 15,  1997 (the  "RECORD  DATE"),  each Right
representing  the right to purchase  one  one-thousandth  of a share of Series A
Participating  Preferred  Stock (as such number may be adjusted  pursuant to the
provisions of this Agreement), having the rights, preferences and privileges set
forth in the form of  Certificate of  Designations  of Rights,  Preferences  and
Privileges of Series A Participating  Preferred Stock attached hereto as Exhibit
A, upon the terms and subject to the  conditions  herein set forth,  and further
authorized  and  directed  the  issuance  of one  Right (as such  number  may be
adjusted  pursuant to the  provisions  of this  Agreement)  with respect to each
Common  Share that shall  become  outstanding  between  the Record  Date and the
earlier  of the  Distribution  Date and the  Expiration  Date (as such terms are
hereinafter defined), and in certain circumstances after the Distribution Date.

     NOW, THEREFORE,  in consideration of the promises and the mutual agreements
herein set forth, the parties hereby agree as follows:

Section 1 Certain Definitions.

     For  purposes of this  Agreement,  the  following  terms have the  meanings
indicated:

(a)  "ACQUIRING  PERSON"  shall mean any Person who or which,  together with all
     Affiliates and Associates of such Person,  shall be the Beneficial Owner of
     15% or more of the Common  Shares then  outstanding,  but shall not include
     the Company,  any Subsidiary of the Company or any employee benefit plan of
     the Company or of any  Subsidiary  of the  Company,  or any entity  holding
     Common   Shares   for  or   pursuant   to  the  terms  of  any  such  plan.
     Notwithstanding the foregoing, no Person shall be deemed to be an Acquiring
     Person as the  result of an  acquisition  of Common  Shares by the  Company
     which,  by  reducing  the  number  of  shares  outstanding,  increases  the
     proportionate  number of shares beneficially owned by such Person to 15% or
     more of the  Common  Shares  of the  Company  then  outstanding;  provided,
     however,  that if a Person shall become the Beneficial Owner of 15% or more
     of the Common  Shares of the Company  then  outstanding  by reason of share
     purchases  by the  Company  and shall,  after such share  purchases  by the
     Company, become the Beneficial Owner of any additional Common Shares of the
     Company (other than pursuant to a dividend or distribution  paid or made by
     the Company on the  outstanding  Common Shares in Common Shares or pursuant
     to a split or  subdivision of the  outstanding  Common  Shares),  then such
     Person shall be deemed to be an Acquiring  Person  unless upon becoming the
     Beneficial  Owner of such  additional  Common  Shares of the  Company  such
     Person does not  beneficially  own 15% or more of the Common  Shares of the



     Company then outstanding.  Notwithstanding the foregoing,  (i) if the Board
     of Directors  determines in good faith that a Person who would otherwise be
     an "Acquiring  Person," as defined pursuant to the foregoing  provisions of
     this  paragraph  (a),  has become such  inadvertently  (including,  without
     limitation,  because (A) such Person was unaware that it beneficially owned
     a percentage of the Common Shares that would otherwise cause such Person to
     be an "Acquiring Person," or (B) such Person was aware of the extent of the
     Common  Shares it  beneficially  owned but had no actual  knowledge  of the
     consequences of such beneficial ownership under this Agreement) and without
     any  intention of changing or  influencing  control of the Company,  and if
     such Person  divested or divests as promptly as  practicable  a  sufficient
     number  of  Common  Shares  so that  such  Person  would  no  longer  be an
     "Acquiring  Person,"  then such Person shall not be deemed to be or to have
     become an "Acquiring  Person" for any purposes of this Agreement;  and (ii)
     if, as of the date  hereof,  any Person is the  Beneficial  Owner of 15% or
     more of the Common Shares  outstanding,  such Person shall not be or become
     an  "Acquiring  Person,"  unless and until such time as such  Person  shall
     become  the  Beneficial  Owner of  additional  Common  Shares  (other  than
     pursuant to a dividend or  distribution  paid or made by the Company on the
     outstanding  Common  Shares in  Common  Shares  or  pursuant  to a split or
     subdivision of the outstanding  Common Shares),  unless,  upon becoming the
     Beneficial Owner of such additional Common Shares,  such Person is not then
     the Beneficial Owner of 15% or more of the Common Shares then outstanding.

(b)  "ADJUSTMENT  FRACTION" shall have the meaning set forth in Section 11(a)(i)
     hereof.

(c)  "AFFILIATE" and "ASSOCIATE" shall have the respective  meanings ascribed to
     such terms in Rule 12b-2 of the  General  Rules and  Regulations  under the
     Exchange Act, as in effect on the date of this Agreement.

(d)  A Person shall be deemed the  "BENEFICIAL  OWNER" of and shall be deemed to
     "BENEFICIALLY OWN" any securities:

     (I)  which such person or any of such  person's  affiliates  or  associates
          beneficially  owns,  directly or  indirectly,  for purposes of section
          13(d) of the exchange act and rule 13d-3 thereunder (or any comparable
          or successor law or regulation);

     (ii) which such person or any of such person's affiliates or associates has
          (a)  the  right  to  acquire   (whether  such  right  is   exercisable
          immediately  or only  after  the  passage  of  time)  pursuant  to any
          agreement,   arrangement  or   understanding   (other  than  customary
          agreements  with and between  underwriters  and selling  group members
          with respect to a bona fide public  offering of  securities),  or upon
          the exercise of conversion rights, exchange rights, rights (other than
          the rights),  warrants or options,  or otherwise;  provided,  however,
          that a person shall not be deemed pursuant to this section 1(d)(ii)(a)
          to be the beneficial owner of, or to beneficially  own, (1) securities
          tendered  pursuant to a tender or exchange  offer made by or on behalf



          of such person or any of such person's  affiliates or associates until
          such tendered securities are accepted for purchase or exchange, or (2)
          securities  which a  person  or any of  such  person's  affiliates  or
          associates may be deemed to have the right to acquire  pursuant to any
          merger or other  acquisition  agreement  between  the company and such
          person  (or one or  more  of its  affiliates  or  associates)  if such
          agreement has been  approved by the board of directors  prior to there
          being an acquiring  person;  or (b) the right to vote  pursuant to any
          agreement,  arrangement or understanding;  provided,  however,  that a
          person shall not be deemed the beneficial owner of, or to beneficially
          own, any security  under this section  1(d)(ii)(b)  if the  agreement,
          arrangement or  understanding  to vote such security (1) arises solely
          from a revocable  proxy or consent given to such person in response to
          a public  proxy or  consent  solicitation  made  pursuant  to,  and in
          accordance  with, the applicable rules and regulations of the exchange
          act and (2) is not also  then  reportable  on  schedule  13d under the
          exchange act (or any comparable or successor report); or

     (iii)which are  beneficially  owned,  directly or indirectly,  by any other
          person (or any affiliate or associate  thereof) with which such person
          or any of such person's  affiliates or associates  has any  agreement,
          arrangement  or  understanding,  whether or not in writing (other than
          customary  agreements with and between  underwriters and selling group
          members with respect to a bona fide public offering of securities) for
          the  purpose  of  acquiring,  holding,  voting  (except  to the extent
          contemplated  by the proviso to section  1(d)(ii)(b))  or disposing of
          any  securities  of the company;  provided,  however,  that in no case
          shall  an  officer  or  director  of the  company  be  deemed  (x) the
          beneficial  owner of any  securities  beneficially  owned  by  another
          officer  or  director  of the  company  solely by  reason  of  actions
          undertaken by such persons in their  capacity as officers or directors
          of the  company  or (y) the  beneficial  owner of  securities  held of
          record by the trustee of any  employee  benefit plan of the company or
          any  subsidiary  of the company for the benefit of any employee of the
          company or any  subsidiary  of the company,  other than the officer or
          director, by reason of any influence that such officer or director may
          have over the voting of the securities held in the plan.

(e)  "BUSINESS DAY" shall mean any day other than a Saturday, Sunday or a day on
     which banking  institutions  in New York are authorized or obligated by law
     or executive order to close.

(f)  "CLOSE OF BUSINESS" on any given date shall mean 5:00 P.M.,  New York time,
     on such date; provided, however, that if such date is not a Business Day it
     shall mean 5:00 P.M., New York time, on the next succeeding Business Day.

(g)  "COMMON  SHARES"  when used with  reference  to the Company  shall mean the
     shares of Common Stock of the Company, $0.001 par value. Common Shares when
     used with  reference  to any Person  other than the Company  shall mean the
     capital stock (or equity  interest) with the greatest  voting power of such
     other Person or, if such other Person is a  Subsidiary  of another  Person,
     the Person or Persons which ultimately control such first-mentioned Person.


(h)  "COMMON  STOCK  EQUIVALENTS"  shall have the  meaning  set forth in Section
     11(a)(iii) hereof.

(i)  "COMPANY" shall mean NEUROCRINE BIOSCIENCES,  INC., a Delaware corporation,
     subject to the terms of Section 13(a)(iii)(C) hereof.

(j)  "CURRENT PER SHARE MARKET PRICE" of any security (a "Security" for purposes
     of this definition), for all computations other than those made pursuant to
     Section  11(a)(iii)  hereof,  shall mean the  average of the daily  closing
     prices per share of such Security for the thirty (30)  consecutive  Trading
     Days immediately  prior to such date, and for purposes of computations made
     pursuant to Section  11(a)(iii)  hereof, the Current Per Share Market Price
     of any  Security on any date shall be deemed to be the average of the daily
     closing  prices  per share of such  Security  for the ten (10)  consecutive
     Trading Days immediately prior to such date; provided, however, that in the
     event that the Current Per Share Market Price of the Security is determined
     during a period  following the  announcement by the issuer of such Security
     of (i) a dividend or  distribution  on such  Security  payable in shares of
     such  Security  or  securities  convertible  into  such  shares or (ii) any
     subdivision, combination or reclassification of such Security, and prior to
     the  expiration  of the  applicable  thirty  (30)  Trading  Day or ten (10)
     Trading  Day  period,  after  the  ex-dividend  date for such  dividend  or
     distribution,  or the  record  date for such  subdivision,  combination  or
     reclassification, then, and in each such case, the Current Per Share Market
     Price shall be  appropriately  adjusted to reflect the current market price
     per share equivalent of such Security. The closing price for each day shall
     be the last sale price,  regular  way, or, in case no such sale takes place
     on such day, the average of the closing bid and asked prices,  regular way,
     in  either  case as  reported  in the  principal  consolidated  transaction
     reporting  system with respect to securities  listed or admitted to trading
     on the New York  Stock  Exchange  or,  if the  Security  is not  listed  or
     admitted  to trading on the New York Stock  Exchange,  as  reported  in the
     principal  consolidated   transaction  reporting  system  with  respect  to
     securities listed on the principal  national  securities  exchange on which
     the  Security is listed or  admitted to trading or, if the  Security is not
     listed or admitted to trading on any national securities exchange, the last
     sale price or, if such last sale price is not reported,  the average of the
     high bid and low asked prices in the  over-the-counter  market, as reported
     by Nasdaq or such  other  system  then in use,  or, if on any such date the
     Security is not quoted by any such organization, the average of the closing
     bid and asked prices as furnished by a  professional  market maker making a
     market in the Security  selected by the Board of Directors.  If on any such
     date no market maker is making a market in the Security,  the fair value of
     such  shares  on such  date as  determined  in good  faith by the  Board of
     Directors shall be used. If the Preferred  Shares are not publicly  traded,
     the  Current  Per  Share  Market  Price of the  Preferred  Shares  shall be
     conclusively  deemed to be the Current Per Share Market Price of the Common
     Shares as  determined  pursuant  to this  Section  1(k),  as  appropriately
     adjusted to reflect any stock split, stock dividend or similar  transaction
     occurring after the date hereof, multiplied by 1000. If the Security is not
     publicly held or so listed or traded,  Current Per Share Market Price shall
     mean the fair value per share as  determined  in good faith by the Board of
     Directors, whose determination shall be described in a statement filed with
     the Rights Agent and shall be conclusive for all purposes.

(k)  "CURRENT  VALUE"  shall have the  meaning  set forth in Section  11(a)(iii)
     hereof.


(l)  "DISTRIBUTION  DATE" shall mean the earlier of (i) the Close of Business on
     the tenth day (or such  later  date as may be  determined  by action of the
     Board of Directors) after the Shares  Acquisition Date or (ii) the Close of
     Business on the tenth Business Day (or such later date as may be determined
     by  action  of the  Board of  Directors)  after  the date  that a tender or
     exchange offer by any Person (other than the Company, any Subsidiary of the
     Company,  any employee  benefit plan of the Company or of any Subsidiary of
     the Company, or any Person or entity organized, appointed or established by
     the  Company  for or  pursuant  to the  terms  of any  such  plan) is first
     published  or sent or given  within  the  meaning of Rule  14d-2(a)  of the
     General  Rules and  Regulations  under the Exchange  Act, if,  assuming the
     successful consummation thereof, such Person would be an Acquiring Person.

(m)  "EQUIVALENT  SHARES"  shall mean  Preferred  Shares and any other  class or
     series  of  capital  stock of the  Company  which is  entitled  to the same
     rights, privileges and preferences as the Preferred Shares.

(n)  "EXCHANGE ACT" shall mean the Securities Exchange Act of 1934, as amended.

(o)  "EXCHANGE RATIO" shall have the meaning set forth in Section 24(a) hereof.

(p)  "EXERCISE PRICE" shall have the meaning set forth in Section 4(a) hereof.

(q)  "EXPIRATION  DATE"  shall mean the  earliest  to occur of: (i) the Close of
     Business on the Final  Expiration  Date,  (ii) the Redemption  Date,  (iii)
     consummation  of any transaction  contemplated by Section 13(f) hereof,  or
     (iv) the time at which the Board of  Directors  orders the  exchange of the
     Rights as provided in Section 24 hereof.

(r)  "FINAL EXPIRATION DATE" shall mean April 10, 2007.

(s)  "NASDAQ" shall mean the National  Association of Securities  Dealers,  Inc.
     Automated Quotations System.

(t)  "PERMITTED  OFFER"  shall mean a tender  offer for all  outstanding  Common
     Shares made in the manner  prescribed  by Section 14(d) of the Exchange Act
     and the rules and regulations  promulgated thereunder;  provided,  however,
     that such tender  offer  occurs at a time when the Board of  Directors  has
     determined  that the offer is both fair and otherwise in the best interests
     of the Company and its  stockholders  (taking into account all factors that
     the Board of Directors deems relevant).

(u)  "PERSON" shall mean any individual,  firm, corporation or other entity, and
     shall include any successor (by merger or otherwise) of such entity.

(v)  "POST-EVENT  TRANSFEREE"  shall have the meaning set forth in Section  7(e)
     hereof.


(w)  "PREFERRED  SHARES" shall mean shares of Series A  Participating  Preferred
     Stock, $0.001 par value, of the Company.

(x)  "PRE-EVENT  TRANSFEREE"  shall have the meaning  set forth in Section  7(e)
     hereof.

(y)  "PRINCIPAL PARTY" shall have the meaning set forth in Section 13(b) hereof.

(z)  "RECORD  DATE"  shall have the  meaning  set forth in the  recitals  at the
     beginning of this Agreement.

(aa) "REDEMPTION DATE" shall have the meaning set forth in Section 23(a) hereof.

(bb) "REDEMPTION  PRICE"  shall  have the  meaning  set forth in  Section  23(a)
     hereof.

(cc) "RIGHTS  AGENT" shall mean American  Stock  Transfer & Trust Company or its
     successor or replacement as provided in Sections 19 and 21 hereof.

(dd) "RIGHTS  CERTIFICATE"  shall mean a certificate  substantially  in the form
     attached hereto as Exhibit B. ---------

(ee) "RIGHTS DIVIDEND  DECLARATION DATE" shall have the meaning set forth in the
     recitals at the beginning of this Agreement.

(ff) "SECTION  11(A)(II)  TRIGGER  DATE"  shall  have the  meaning  set forth in
     Section 11(a)(iii) hereof.

(gg) "SECTION 13 EVENT" shall mean any event  described  in clause (i),  (ii) or
     (iii) of Section 13(a) hereof.

(hh) "SECURITIES ACT" shall mean the Securities Act of 1933, as amended.

(ii) "SHARES  ACQUISITION DATE" shall mean the first date of public announcement
     (which, for purposes of this definition, shall include, without limitation,
     a report filed  pursuant to Section  13(d) under the  Exchange  Act) by the
     Company or an Acquiring  Person that an  Acquiring  Person has become such;
     provided that, if such Person is determined not to have become an Acquiring
     Person  pursuant to Section 1(a) hereof,  then no Shares  Acquisition  Date
     shall be deemed to have occurred.

(jj) "SPREAD" shall have the meaning set forth in Section 11(a)(iii) hereof.


(kk) "SUBSIDIARY"  of any Person shall mean any  corporation  or other entity of
     which an amount of voting securities  sufficient to elect a majority of the
     directors or Persons having similar  authority of such corporation or other
     entity is beneficially  owned,  directly or indirectly,  by such Person, or
     any corporation or other entity otherwise controlled by such Person.

(ll) "SUBSTITUTION   PERIOD"  shall  have  the  meaning  set  forth  in  Section
     11(a)(iii) hereof.

(mm) "SUMMARY OF RIGHTS" shall mean a summary of this Agreement substantially in
     the form attached hereto as Exhibit C.

(nn) "TOTAL  EXERCISE  PRICE"  shall have the meaning set forth in Section  4(a)
     hereof.

(oo) "TRADING DAY" shall mean a day on which the principal  national  securities
     exchange on which a referenced security is listed or admitted to trading is
     open for the  transaction  of business or, if a referenced  security is not
     listed or  admitted  to  trading on any  national  securities  exchange,  a
     Business Day.

(pp) "TRIGGERING  EVENT"  shall be  deemed  to have  occurred  upon  any  Person
     becoming an Acquiring Person.

Section 2 Appointment of Rights Agent.

     The  Company  hereby  appoints  the  Rights  Agent to act as agent  for the
Company and the holders of the Rights (who, in accordance with Section 3 hereof,
shall prior to the  Distribution  Date also be the holders of the Common Shares)
in accordance with the terms and conditions  hereof, and the Rights Agent hereby
accepts  such  appointment.  The  Company  may from  time to time  appoint  such
co-Rights Agents as it may deem necessary or desirable.

Section 3 Issuance of Rights Certificates.

(a)  Until the Distribution  Date, (i) the Rights will be evidenced  (subject to
     the  provisions of Sections 3(b) and 3(c) hereof) by the  certificates  for
     Common  Shares  registered  in the  names  of the  holders  thereof  (which
     certificates  shall  also be deemed to be Rights  Certificates)  and not by
     separate  Rights   Certificates  and  (ii)  the  right  to  receive  Rights
     Certificates  will be transferable  only in connection with the transfer of
     Common Shares. Until the earlier of the Distribution Date or the Expiration
     Date,  the surrender for transfer of  certificates  for Common Shares shall
     also  constitute the surrender for transfer of the Rights  associated  with
     the Common Shares  represented  thereby.  As soon as practicable  after the
     Distribution  Date, the Company will prepare and execute,  the Rights Agent
     will  countersign,  and the Company  will send or cause to be sent (and the
     Rights Agent will,  if  requested,  send) by  first-class,  postage-prepaid
     mail, to each record holder of Common Shares as of the Close of Business on
     the  Distribution  Date, at the address of such holder shown on the records
     of the Company, a Rights  Certificate  evidencing one Right for each Common
     Share so held,  subject to adjustment as provided herein. In the event that
     an  adjustment  in the  number of  Rights  per  Common  Share has been made
     pursuant  to  Section 11 hereof,  then at the time of  distribution  of the
     Rights  Certificates,  the Company shall make the necessary and appropriate



     rounding  adjustments  (in  accordance  with Section  14(a) hereof) so that
     Rights   Certificates   representing  only  whole  numbers  of  Rights  are
     distributed  and cash is paid in lieu of any fractional  Rights.  As of the
     Distribution  Date,  the Rights  will be  evidenced  solely by such  Rights
     Certificates  and  may  be  transferred  by  the  transfer  of  the  Rights
     Certificates as permitted hereby, separately and apart from any transfer of
     Common Shares, and the holders of such Rights Certificates as listed in the
     records of the Company or any transfer  agent or  registrar  for the Rights
     shall be the record holders thereof.

(b)  On or about the Record  Date,  the  Company  sent a copy of the  Summary of
     Rights by  first-class,  postage-prepaid  mail,  to each  record  holder of
     Common  Shares as of the  Close of  Business  on the  Record  Date,  at the
     address of such holder shown on the records of the Company's transfer agent
     and registrar.  With respect to certificates for Common Shares  outstanding
     as of the Record  Date,  until the  Distribution  Date,  the Rights will be
     evidenced  by such  certificates  registered  in the  names of the  holders
     thereof together with the Summary of Rights.  Until the  Distribution  Date
     (or, if earlier,  the Expiration  Date),  the surrender for transfer of any
     certificate  for Common  Shares  outstanding  on the Record  Date,  with or
     without a copy of the Summary of Rights, shall also constitute the transfer
     of the Rights associated with the Common Shares represented thereby.

(c)  Unless the Board of Directors by  resolution  adopted at or before the time
     of the  issuance of any Common  Shares  specifies to the  contrary,  Rights
     shall be issued in respect of all Common  Shares that are issued  after the
     Record  Date  but  prior to the  earlier  of the  Distribution  Date or the
     Expiration Date or, in certain circumstances provided in Section 22 hereof,
     after the Distribution Date.  Certificates  representing such Common Shares
     shall  also be deemed to be  certificates  for  Rights,  and shall bear the
     following legend:

         THIS  CERTIFICATE  ALSO  EVIDENCES  AND ENTITLES  THE HOLDER  HEREOF TO
         CERTAIN RIGHTS AS SET FORTH IN A RIGHTS  AGREEMENT  BETWEEN  NEUROCRINE
         BIOSCIENCES,  INC. AND AMERICAN STOCK TRANSFER & TRUST COMPANY,  AS THE
         RIGHTS  AGENT (THE "RIGHTS  AGREEMENT"),  THE TERMS OF WHICH ARE HEREBY
         INCORPORATED  HEREIN BY REFERENCE AND A COPY OF WHICH IS ON FILE AT THE
         PRINCIPAL  EXECUTIVE  OFFICES OF NEUROCRINE  BIOSCIENCES,  INC.,  UNDER
         CERTAIN  CIRCUMSTANCES,  AS SET  FORTH IN THE  RIGHTS  AGREEMENT,  SUCH
         RIGHTS WILL BE EVIDENCED BY SEPARATE CERTIFICATES AND WILL NO LONGER BE
         EVIDENCED BY THIS CERTIFICATE.  NEUROCRINE BIOSCIENCES,  INC. WILL MAIL
         TO THE  HOLDER  OF  THIS  CERTIFICATE  A COPY OF THE  RIGHTS  AGREEMENT
         WITHOUT  CHARGE  AFTER  RECEIPT OF A WRITTEN  REQUEST  THEREFOR.  UNDER
         CERTAIN CIRCUMSTANCES SET FORTH IN THE RIGHTS AGREEMENT,  RIGHTS ISSUED
         TO, OR HELD BY, ANY PERSON WHO IS, WAS OR BECOMES AN  ACQUIRING  PERSON



         OR ANY AFFILIATE OR ASSOCIATE THEREOF (AS SUCH TERMS ARE DEFINED IN THE
         RIGHTS  AGREEMENT),  WHETHER  CURRENTLY  HELD BY OR ON  BEHALF  OF SUCH
         PERSON OR BY ANY SUBSEQUENT HOLDER, MAY BECOME NULL AND VOID.

     With respect to such certificates  containing the foregoing  legend,  until
the earlier of (i) the Distribution Date or (ii) the Expiration Date, the Rights
associated  with the Common Shares  represented  by such  certificates  shall be
evidenced by such certificates alone, and the surrender for transfer of any such
certificate shall also constitute the transfer of the Rights associated with the
Common Shares represented thereby.

(d)  In the event that the Company purchases or acquires any Common Shares after
     the Record Date but prior to the Distribution  Date, any Rights  associated
     with such Common  Shares  shall be deemed  canceled and retired so that the
     Company  shall not be entitled to exercise any Rights  associated  with the
     Common Shares which are no longer outstanding.

Section 4 Form of Rights Certificates.

(a)  The Rights  Certificates  (and the forms of  election  to  purchase  Common
     Shares and of  assignment  to be printed on the reverse  thereof)  shall be
     substantially  in the form of  Exhibit B hereto  and may have such marks of
     identification  or designation and such legends,  summaries or endorsements
     printed  thereon  as the  Company  may  deem  appropriate  and  as are  not
     inconsistent  with the provisions of this Agreement,  or as may be required
     to  comply  with any  applicable  law or with any rule or  regulation  made
     pursuant  thereto or with any rule or regulation of any stock exchange or a
     national market system, on which the Rights may from time to time be listed
     or included,  or to conform to usage.  Subject to the provisions of Section
     11 and Section 22 hereof, the Rights  Certificates,  whenever  distributed,
     shall be dated as of the Record Date (or in the case of Rights  issued with
     respect to Common Shares issued by the Company after the Record Date, as of
     the date of issuance of such Common Shares) and on their face shall entitle
     the  holders  thereof to  purchase  such  number of one-  thousandths  of a
     Preferred  Share as shall be set  forth  therein  at the  price  set  forth
     therein (such exercise price per one  one-thousandth  of a Preferred  Share
     being  hereinafter  referred to as the  "EXERCISE  PRICE" and the aggregate
     Exercise Price of all Preferred  Shares issuable upon exercise of one Right
     being  hereinafter  referred  to as the "TOTAL  EXERCISE  PRICE"),  but the
     number and type of securities  purchasable  upon the exercise of each Right
     and the Exercise Price shall be subject to adjustment as provided herein.

(b)  Any Rights Certificate issued pursuant to Section 3(a) or Section 22 hereof
     that represents  Rights  beneficially  owned by: (i) an Acquiring Person or
     any Associate or Affiliate of an Acquiring Person,  (ii) a transferee of an
     Acquiring  Person (or of any such  Associate  or  Affiliate)  who becomes a
     transferee after the Acquiring Person becomes such or (iii) a transferee of
     an Acquiring  Person (or of any such  Associate or Affiliate) who becomes a
     transferee prior to or concurrently with the Acquiring Person becoming such
     and receives such Rights pursuant to either (A) a transfer  (whether or not
     for consideration) from the Acquiring Person to holders of equity interests
     in such Acquiring  Person or to any Person with whom such Acquiring  Person
     has any continuing  agreement,  arrangement or understanding  regarding the
     transferred  Rights or (B) a  transfer  which the  Board of  Directors  has
     determined is part of a plan,  arrangement or understanding  which has as a
     primary purpose or effect avoidance of Section 7(e) hereof,  and any Rights
     Certificate  issued  pursuant  to  Section  6 or  Section  11  hereof  upon



     transfer,   exchange,   replacement  or  adjustment  of  any  other  Rights
     Certificate  referred  to in this  sentence,  shall  contain (to the extent
     feasible) the following legend:

         THE  RIGHTS   REPRESENTED  BY  THIS  RIGHTS  CERTIFICATE  ARE  OR  WERE
         BENEFICIALLY OWNED BY A PERSON WHO WAS OR BECAME AN ACQUIRING PERSON OR
         AN AFFILIATE  OR  ASSOCIATE  OF AN ACQUIRING  PERSON (AS SUCH TERMS ARE
         DEFINED IN THE RIGHTS AGREEMENT).  ACCORDINGLY, THIS RIGHTS CERTIFICATE
         AND THE  RIGHTS  REPRESENTED  HEREBY  MAY  BECOME  NULL AND VOID IN THE
         CIRCUMSTANCES SPECIFIED IN SECTION 7(e) OF THE RIGHTS AGREEMENT.

Section 5 Countersignature and Registration.

(a)  The Rights  Certificates  shall be executed on behalf of the Company by its
     Chairman of the Board,  its Chief  Executive  Officer,  its Chief Financial
     Officer,  its  President  or any  Vice  President,  either  manually  or by
     facsimile signature,  and by the Secretary or an Assistant Secretary of the
     Company, either manually or by facsimile signature,  and shall have affixed
     thereto  the  Company's  seal (if any) or a facsimile  thereof.  The Rights



     Certificates shall be manually  countersigned by the Rights Agent and shall
     not be valid for any purpose unless  countersigned.  In case any officer of
     the  Company  who shall have  signed any of the Rights  Certificates  shall
     cease to be such  officer of the  Company  before  countersignature  by the
     Rights  Agent  and  issuance  and  delivery  by the  Company,  such  Rights
     Certificates,  nevertheless,  may be  countersigned by the Rights Agent and
     issued  and  delivered  by the  Company  with the same  force and effect as
     though  the person who signed  such  Rights  Certificates  on behalf of the
     Company had not ceased to be such  officer of the  Company;  and any Rights
     Certificate  may be signed on behalf of the  Company by any person  who, at
     the actual date of the  execution  of such Rights  Certificate,  shall be a
     proper officer of the Company to sign such Rights Certificate,  although at
     the date of the execution of this Rights  Agreement any such person was not
     such an officer.

(b)  Following the Distribution  Date, the Rights Agent will keep or cause to be
     kept, at its office  designated for such purposes,  books for  registration
     and transfer of the Rights Certificates issued hereunder.  Such books shall
     show the  names and  addresses  of the  respective  holders  of the  Rights
     Certificates,  the  number of Rights  evidenced  on its face by each of the
     Rights Certificates and the date of each of the Rights Certificates.

Section 6 Transfer, Split Up,

     Combination and Exchange of Rights Certificates; Mutilated, Destroyed, Lost
or Stolen Rights Certificates.

(a)  Subject to the provisions of Sections  7(e), 14 and 24 hereof,  at any time
     after the Close of Business on the  Distribution  Date,  and at or prior to
     the Close of Business on the  Expiration  Date,  any Rights  Certificate or
     Rights Certificates may be transferred, split up, combined or exchanged for
     another Rights Certificate or Rights Certificates, entitling the registered
     holder to purchase a like number of  one-thousandths  of a Preferred  Share
     (or, following a Triggering Event, other securities,  cash or other assets,
     as the  case  may be) as the  Rights  Certificate  or  Rights  Certificates
     surrendered  then entitled such holder to purchase.  Any registered  holder
     desiring to transfer,  split up, combine or exchange any Rights Certificate
     or Rights  Certificates shall make such request in writing delivered to the
     Rights  Agent,  and  shall  surrender  the  Rights  Certificate  or  Rights
     Certificates  to be  transferred,  split up,  combined or  exchanged at the
     office of the Rights Agent designated for such purpose.  Neither the Rights
     Agent nor the Company shall be obligated to take any action whatsoever with
     respect to the transfer of any such surrendered  Rights  Certificate  until
     the  registered  holder  shall have  completed  and signed the  certificate
     contained  in the form of  assignment  on the  reverse  side of such Rights
     Certificate  and  shall  have  provided  such  additional  evidence  of the
     identity of the Beneficial Owner (or former Beneficial Owner) or Affiliates
     or Associates  thereof as the Company shall reasonably  request.  Thereupon
     the  Rights  Agent  shall,  subject  to  Sections  7(e),  14 and 24 hereof,
     countersign and deliver to the person entitled thereto a Rights Certificate
     or Rights  Certificates,  as the case may be, as so requested.  The Company
     may require  payment of a sum  sufficient to cover any tax or  governmental
     charge  that may be  imposed in  connection  with any  transfer,  split up,
     combination or exchange of Rights Certificates.

(b)  Upon  receipt by the  Company and the Rights  Agent of evidence  reasonably
     satisfactory  to them of the loss,  theft,  destruction  or mutilation of a
     Rights  Certificate,  and,  in case  of  loss,  theft  or  destruction,  of
     indemnity  or  security  reasonably  satisfactory  to  them,  and,  at  the
     Company's request, reimbursement to the Company and the Rights Agent of all
     reasonable expenses  incidental  thereto,  and upon surrender to the Rights
     Agent and cancellation of the Rights Certificate if mutilated,  the Company
     will make and deliver a new Rights  Certificate of like tenor to the Rights
     Agent  for  delivery  to the  registered  holder  in  lieu  of  the  Rights
     Certificate so lost, stolen, destroyed or mutilated.

Section 7 Exercise of Rights; Exercise Price; Expiration Date of Rights.

(a)  Subject to Sections 7(e), 23(b) and 24(b) hereof,  the registered holder of
     any Rights Certificate may exercise the Rights evidenced thereby (except as
     otherwise  provided  herein)  in  whole or in part at any  time  after  the
     Distribution Date and prior to the Close of Business on the Expiration Date
     by  surrender  of the  Rights  Certificate,  with the form of  election  to
     purchase on the reverse side thereof duly executed,  to the Rights Agent at
     the office of the Rights Agent  designated for such purpose,  together with
     payment of the Exercise Price for each  one-thousandth of a Preferred Share
     (or, following a Triggering Event,  other securities,  cash or other assets
     as the case may be) as to which the Rights are exercised.

(b)  The Exercise Price for each  one-thousandth  of a Preferred  Share issuable
     pursuant to the exercise of a Right shall  initially  be $350.00,  shall be
     subject to  adjustment  from time to time as provided in Sections 11 and 13
     hereof and shall be payable in lawful money of the United States of America
     in accordance with paragraph (c) below.

(c)  Upon receipt of a Rights Certificate  representing exercisable Rights, with
     the form of election to purchase duly  executed,  accompanied by payment of
     the Exercise Price for the number of  one-thousandths  of a Preferred Share
     (or, following a Triggering Event,  other securities,  cash or other assets
     as the case may be) to be purchased  and an amount equal to any  applicable



     transfer tax  required to be paid by the holder of such Rights  Certificate
     in accordance with Section 9(e) hereof, the Rights Agent shall,  subject to
     Section  20(k)  hereof,  thereupon  promptly (i) (A)  requisition  from any
     transfer agent of the Preferred  Shares (or make  available,  if the Rights
     Agent is the transfer  agent for the  Preferred  Shares) a  certificate  or
     certificates  for the number of  one-thousandths  of a Preferred Share (or,
     following a Triggering Event, other securities, cash or other assets as the
     case may be) to be purchased and the Company hereby irrevocably  authorizes
     its transfer  agent to comply with all such  requests or (B) if the Company
     shall have  elected to deposit  the total  number of  one-thousandths  of a
     Preferred Share (or, following a Triggering Event,  other securities,  cash
     or other  assets as the case may be) issuable  upon  exercise of the Rights
     hereunder with a depositary  agent,  requisition  from the depositary agent
     depositary  receipts  representing  such  number  of  one-thousandths  of a
     Preferred Share (or, following a Triggering Event,  other securities,  cash
     or other assets as the case may be) as are to be  purchased  (in which case
     certificates  for the Preferred Shares (or,  following a Triggering  Event,
     other  securities,  cash or other assets as the case may be) represented by
     such receipts  shall be deposited by the transfer agent with the depositary
     agent) and the Company hereby  directs the depositary  agent to comply with
     such  request,  (ii) when  appropriate,  requisition  from the  Company the
     amount  of cash to be paid in lieu of  issuance  of  fractional  shares  in
     accordance with Section 14 hereof, (iii) after receipt of such certificates
     or depositary receipts, cause the same to be delivered to or upon the order
     of the  registered  holder of such Rights  Certificate,  registered in such
     name  or  names  as  may  be  designated  by  such  holder  and  (iv)  when
     appropriate,  after receipt thereof, deliver such cash to or upon the order
     of the  registered  holder of such Rights  Certificate.  The payment of the
     Exercise Price (as such amount may be reduced  (including to zero) pursuant
     to  Section  11(a)(iii)  hereof)  and an  amount  equal  to any  applicable
     transfer tax  required to be paid by the holder of such Rights  Certificate
     in accordance with Section 9(e) hereof, may be made in cash or by certified
     bank  check,  cashier's  check or bank  draft  payable  to the order of the
     Company.  In the event that the Company is obligated to issue securities of
     the Company other than Preferred  Shares,  pay cash and/or distribute other
     property  pursuant  to Section  11(a)  hereof,  the  Company  will make all
     arrangements  necessary  so that such other  securities,  cash and/or other
     property are available for  distribution  by the Rights Agent,  if and when
     appropriate.

(d)  In case the registered holder of any Rights Certificate shall exercise less
     than all the Rights evidenced thereby, a new Rights Certificate  evidencing
     Rights  equivalent to the Rights remaining  unexercised  shall be issued by
     the Rights Agent to the registered holder of such Rights  Certificate or to
     his or her duly authorized assigns, subject to the provisions of Section 14
     hereof.

(e)  Notwithstanding  anything in this Agreement to the contrary, from and after
     the first occurrence of a Triggering Event, any Rights  beneficially  owned
     by (i) an  Acquiring  Person or an  Associate  or Affiliate of an Acquiring
     Person,  (ii) a transferee of an Acquiring Person (or of any such Associate
     or Affiliate) who becomes a transferee  after the Acquiring  Person becomes
     such (a "POST-EVENT TRANSFEREE"), (iii) a transferee of an Acquiring Person
     (or of any such Associate or Affiliate)  who becomes a transferee  prior to
     or concurrently  with the Acquiring  Person becoming such and receives such
     Rights pursuant to either (A) a transfer (whether or not for consideration)
     from the Acquiring  Person to holders of equity interests in such Acquiring
     Person or to any Person with whom the Acquiring  Person has any  continuing
     agreement, arrangement or understanding regarding the transferred Rights or



     (B) a transfer  which the Board of Directors  has  determined  is part of a
     plan, arrangement or understanding which has as a primary purpose or effect
     the avoidance of this Section 7(e) (a "PRE-EVENT  TRANSFEREE")  or (iv) any
     subsequent  transferee  receiving  transferred  Rights  from  a  Post-Event
     Transferee  or a Pre-Event  Transferee,  either  directly or through one or
     more  intermediate  transferees,  shall  become  null and void  without any
     further  action  and no  holder  of  such  Rights  shall  have  any  rights
     whatsoever with respect to such Rights, whether under any provision of this
     Agreement or  otherwise.  The Company shall use all  reasonable  efforts to
     ensure that the provisions of this Section 7(e) and Section 4(b) hereof are
     complied  with,  but  shall  have no  liability  to any  holder  of  Rights
     Certificates  or to any other Person as a result of its failure to make any
     determinations with respect to an Acquiring Person or any of such Acquiring
     Person's Affiliates, Associates or transferees hereunder.

(f)  Notwithstanding  anything in this  Agreement to the  contrary,  neither the
     Rights Agent nor the Company  shall be  obligated  to undertake  any action
     with respect to a registered  holder upon the  occurrence  of any purported
     exercise  as set forth in this  Section  7 unless  such  registered  holder
     shall,  in addition to having  complied  with the  requirements  of Section
     7(a), have (i) completed and signed the  certificate  contained in the form
     of  election  to  purchase  set  forth on the  reverse  side of the  Rights
     Certificate surrendered for such exercise and (ii) provided such additional
     evidence of the  identity  of the  Beneficial  Owner (or former  Beneficial
     Owner) or Affiliates or Associates  thereof as the Company shall reasonably
     request.

Section 8  Cancellation  and  Destruction  of Rights  Certificates.  All  Rights

     Certificates  surrendered for the purpose of exercise,  transfer, split up,
combination  or exchange  shall,  if surrendered to the Company or to any of its
agents,  be delivered to the Rights Agent for  cancellation or in canceled form,
or, if surrendered  to the Rights Agent,  shall be canceled by it, and no Rights
Certificates  shall be issued in lieu thereof  except as expressly  permitted by
any of the provisions of this Agreement. The Company shall deliver to the Rights
Agent for cancellation and retirement,  and the Rights Agent shall so cancel and
retire,  any Rights  Certificate  purchased or acquired by the Company otherwise
than upon the  exercise  thereof.  The Rights  Agent shall  deliver all canceled
Rights  Certificates  to the Company,  or shall,  at the written  request of the
Company,  destroy  such  canceled  Rights  Certificates,  and in such case shall
deliver a certificate of destruction thereof to the Company.

Section 9 Reservation and Availability of Preferred Shares.

(a)  The Company covenants and agrees that it will use its best efforts to cause
     to be  reserved  and kept  available  out of its  authorized  and  unissued
     Preferred  Shares not  reserved for another  purpose  (and,  following  the
     occurrence of a Triggering Event, out of its authorized and unissued Common
     Shares  and/or  other  securities),  the number of  Preferred  Shares (and,
     following the  occurrence  of the  Triggering  Event,  Common Shares and/or
     other securities) that will be sufficient to permit the exercise in full of
     all outstanding Rights.

(b)  If the  Company  shall  hereafter  list any of its  Preferred  Shares  on a
     national  securities  exchange,  then so long as the Preferred Shares (and,
     following the occurrence of a Triggering Event,  Common Shares and/or other
     securities)  issuable and  deliverable  upon  exercise of the Rights may be
     listed on such  exchange,  the Company shall use its best efforts to cause,
     from and after such time as the Rights become  exercisable (but only to the



     extent that it is reasonably likely that the Rights will be exercised), all
     shares  reserved  for such  issuance  to be  listed on such  exchange  upon
     official notice of issuance upon such exercise.

(c)  The Company shall use its best efforts to (i) file, as soon as  practicable
     following  the  earliest  date after the first  occurrence  of a Triggering
     Event in which  the  consideration  to be  delivered  by the  Company  upon
     exercise  of the  Rights is  described  in  Section  11(a)(ii)  or  Section
     11(a)(iii)  hereof,  or as  soon  as  is  required  by  law  following  the
     Distribution  Date, as the case may be, a registration  statement under the
     Securities Act with respect to the securities  purchasable upon exercise of
     the Rights on an appropriate form, (ii) cause such  registration  statement
     to become  effective  as soon as  practicable  after such  filing and (iii)
     cause such registration statement to remain effective (with a prospectus at
     all times meeting the requirements of the Securities Act) until the earlier
     of (A) the date as of which the Rights are no longer  exercisable  for such
     securities  and (B) the date of expiration  of the Rights.  The Company may
     temporarily  suspend, for a period not to exceed ninety (90) days after the
     date set forth in clause (i) of the first  sentence of this  Section  9(c),
     the  exercisability  of the  Rights  in order  to  prepare  and  file  such
     registration  statement  and permit it to become  effective.  Upon any such
     suspension,  the Company  shall issue a public  announcement  stating,  and
     notify the Rights  Agent,  that the  exercisability  of the Rights has been
     temporarily suspended, as well as a public announcement and notification to
     the Rights Agent at such time as the suspension is no longer in effect. The
     Company  will also take such  action  as may be  appropriate  under,  or to
     ensure  compliance  with,  the securities or "blue sky" laws of the various
     states in connection with the exercisability of the Rights. Notwithstanding
     any provision of this  Agreement to the  contrary,  the Rights shall not be
     exercisable in any jurisdiction, unless the requisite qualification in such
     jurisdiction shall have been obtained,  or an exemption  therefrom shall be
     available, and until a registration statement has been declared effective.

(d)  The Company  covenants  and agrees that it will take all such action as may
     be necessary to ensure that all  Preferred  Shares (or other  securities of
     the  Company)  delivered  upon  exercise  of Rights  shall,  at the time of
     delivery of the certificates for such securities (subject to payment of the
     Exercise Price),  be duly and validly  authorized and issued and fully paid
     and nonassessable shares.

(e)  The  Company  further  covenants  and agrees  that it will pay when due and
     payable any and all federal and state  transfer taxes and charges which may
     be payable in respect of the  original  issuance  or delivery of the Rights
     Certificates  or of  any  Preferred  Shares  (or  other  securities  of the
     Company) upon the exercise of Rights.  The Company shall not,  however,  be
     required  to pay any  transfer  tax which may be  payable in respect of any
     transfer or delivery of Rights  Certificates to a person other than, or the
     issuance  or  delivery  of  certificates  or  depositary  receipts  for the
     Preferred  Shares (or other securities of the Company) in a name other than
     that of, the registered holder of the Rights Certificate  evidencing Rights
     surrendered  for  exercise  or to issue or to deliver any  certificates  or
     depositary  receipts  for  Preferred  Shares  (or other  securities  of the
     Company) upon the exercise of any Rights until any such tax shall have been
     paid (any such tax being  payable by the holder of such Rights  Certificate
     at the time of surrender) or until it has been established to the Company's
     satisfaction that no such tax is due.




Section 10 Record Date.

     Each Person in whose name any certificate  for a number of  one-thousandths
of a Preferred  Share (or other  securities  of the  Company) is issued upon the
exercise of Rights shall for all purposes be deemed to have become the holder of
record of Preferred  Shares (or other  securities  of the  Company)  represented
thereby on, and such certificate  shall be dated, the date upon which the Rights
Certificate evidencing such Rights was duly surrendered and payment of the Total
Exercise  Price with  respect to which the Rights have been  exercised  (and any
applicable transfer taxes) was made; provided, however, that if the date of such
surrender and payment is a date upon which the transfer books of the Company are
closed,  such Person  shall be deemed to have  become the record  holder of such
shares on, and such certificate shall be dated, the next succeeding Business Day
on which the  transfer  books of the Company are open.  Prior to the exercise of
the Rights evidenced  thereby,  the holder of a Rights  Certificate shall not be
entitled to any rights of a holder of Preferred  Shares (or other  securities of
the  Company)  for which the Rights  shall be  exercisable,  including,  without
limitation, the right to vote, to receive dividends or other distributions or to
exercise any preemptive  rights, and shall not be entitled to receive any notice
of any proceedings of the Company, except as provided herein.

Section 11 Adjustment of Exercise Price, Number of Shares or Number of Rights.

     The Exercise Price, the number and kind of shares or other property covered
by each Right and the number of Rights  outstanding  are  subject to  adjustment
from time to time as provided in this Section 11.

(a)

     (i)  anything in this  agreement  to the contrary  notwithstanding,  in the
          event the company  shall at any time after the date of this  agreement
          (a) declare a dividend on the  preferred  shares  payable in preferred
          shares,  (b) subdivide the outstanding  preferred shares,  (c) combine
          the outstanding preferred shares (by reverse stock split or otherwise)
          into a smaller number of preferred  shares, or (d) issue any shares of
          its  capital  stock  in a  reclassification  of the  preferred  shares
          (including   any   such   reclassification   in   connection   with  a
          consolidation  or merger in which the  company  is the  continuing  or
          surviving corporation),  then, in each such event, except as otherwise
          provided in this section 11 and section 7(e) hereof:  (1) the exercise
          price in effect at the time of the record date for such dividend or of
          the   effective   date   of   such    subdivision,    combination   or
          reclassification   shall  be  adjusted  so  that  the  exercise  price
          thereafter  shall equal the result  obtained by dividing  the exercise
          price in  effect  immediately  prior to such time by a  fraction  (the
          "adjustment  fraction"),  the  numerator  of which  shall be the total
          number of preferred  shares (or shares of capital stock issued in such
          reclassification  of the  preferred  shares)  outstanding  immediately
          following  such time and the  denominator  of which shall be the total
          number of preferred shares outstanding immediately prior to such time;
          provided, however, that in no event shall the consideration to be paid
          upon the exercise of one right be less than the aggregate par value of
          the shares of capital  stock of the company  issuable upon exercise of
          such right; and (2) the number of one-thousandths of a preferred share
          (or share of such other capital  stock)  issuable upon the exercise of
          each right  shall equal the number of  one-thousandths  of a preferred
          share (or share of such  other  capital  stock) as was  issuable  upon
          exercise of a right  immediately  prior to the occurrence of the event



          described in clauses (a)-(d) of this section  11(a)(i),  multiplied by
          the adjustment fraction;  provided,  however, that, no such adjustment
          shall be made  pursuant  to this  section  11(a)(i) to the extent that
          there shall have simultaneously  occurred an event described in clause
          (a), (b), (c) or (d) of section 11(n) with a proportionate  adjustment
          being made thereunder. each common share that shall become outstanding
          after an adjustment  has been made  pursuant to this section  11(a)(i)
          shall have associated with it the number of rights, exercisable at the
          exercise  price and for the number of  one-thousandths  of a preferred
          share (or shares of such other capital  stock) as one common share has
          associated with it immediately  following the adjustment made pursuant
          to this section 11(a)(i).

     (ii) subject  to section 24 of this  agreement,  in the event a  triggering
          event shall have occurred,  then promptly  following  such  triggering
          event each  holder of a right,  except as  provided  in  section  7(e)
          hereof,  shall  thereafter  have the right to receive  for each right,
          upon exercise  thereof in accordance  with the terms of this agreement
          and payment of the exercise price in effect  immediately  prior to the
          occurrence  of  the  triggering   event,   in  lieu  of  a  number  of
          one-thousandths  of a preferred share, such number of common shares of
          the company as shall  equal the result  obtained  by  multiplying  the
          exercise  price in effect  immediately  prior to the occurrence of the
          triggering event by the number of one-thousandths of a preferred share
          for which a right was exercisable  (or would have been  exercisable if
          the  distribution  date had occurred)  immediately  prior to the first
          occurrence of a triggering  event, and dividing that product by 50% of
          the current per share  market  price for common  shares on the date of
          occurrence  of the  triggering  event;  provided,  however,  that  the
          exercise  price  and the  number of common  shares of the  company  so
          receivable  upon  exercise  of a right  shall be  subject  to  further
          adjustment as appropriate  in accordance  with section 11(e) hereof to
          reflect any events  occurring  in respect of the common  shares of the
          company after the occurrence of the triggering event.  notwithstanding
          the foregoing  provisions of this section 11(a)(ii),  the right to buy
          common  shares of the  company  pursuant to section  11(a)(ii)  hereof
          shall not arise as a result of any person becoming an acquiring person
          through an acquisition of common shares pursuant to a permitted offer.

     (iii)in lieu of issuing common shares in accordance with section  11(a)(ii)
          hereof,  the company  may, if the board of directors  determines  that
          such  action is  necessary  or  appropriate  and not  contrary  to the
          interest  of  holders of rights  and,  in the event that the number of
          common shares which are  authorized by the  company's  certificate  of
          incorporation  but  not  outstanding  or  reserved  for  issuance  for
          purposes  other than upon exercise of the rights are not sufficient to
          permit  the  exercise  in  full  of the  rights,  or if any  necessary
          regulatory  approval for such  issuance  has not been  obtained by the
          company,  the company shall: (a) determine the excess of (1) the value
          of the  common  shares  issuable  upon the  exercise  of a right  (the
          "current  value")  over  (2) the  exercise  price  (such  excess,  the
          "spread") and (b) with respect to each right, make adequate  provision
          to substitute for such common shares, upon exercise of the rights, (1)
          cash,  (2) a  reduction  in  the  exercise  price,  (3)  other  equity
          securities of the company (including,  without  limitation,  shares or
          units of shares of any series of  preferred  stock  which the board of
          directors  has  deemed to have the same value as common  shares  (such
          shares or units of shares of preferred stock are herein called "common



          stock  equivalents")),  except to the extent  that the company has not
          obtained any necessary  stockholder  or  regulatory  approval for such
          issuance,  (4) debt  securities  of the company,  except to the extent
          that  the  company  has not  obtained  any  necessary  stockholder  or
          regulatory  approval  for such  issuance,  (5) other assets or (6) any
          combination of the foregoing,  having an aggregate  value equal to the
          current value,  where such aggregate  value has been determined by the
          board of directors  based upon the advice of a  nationally  recognized
          investment banking firm selected by the board of directors;  provided,
          however,  if the company  shall not have made  adequate  provision  to
          deliver  value  pursuant to clause (b) above  within  thirty (30) days
          following the later of (x) the first  occurrence of a triggering event
          and (y) the date on which the company's  right of redemption  pursuant
          to section 23(a)  expires (the later of (x) and (y) being  referred to
          herein as the  "section  11(a)(ii)  trigger  date"),  then the company
          shall be obligated to deliver,  upon the  surrender  for exercise of a
          right and without  requiring  payment of the  exercise  price,  common
          shares  (to the  extent  available),  except  to the  extent  that the
          company has not  obtained  any  necessary  stockholder  or  regulatory
          approval for such issuance, and then, if necessary, cash, which shares
          and/or cash have an aggregate value equal to the spread.  if the board
          of  directors  shall  determine  in good faith that it is likely  that
          sufficient  additional  common shares could be authorized for issuance
          upon exercise in full of the rights or that any  necessary  regulatory
          approval  for such  issuance  will be  obtained,  the thirty  (30) day
          period set forth above may be extended  to the extent  necessary,  but
          not more than  ninety (90) days after the  section  11(a)(ii)  trigger
          date, in order that the company may seek stockholder  approval for the
          authorization of such additional  shares or take action to obtain such
          regulatory  approval  (such  period,  as  it  may  be  extended,   the
          "substitution period"). to the extent that the company determines that
          some  action  need  be  taken  pursuant  to the  first  and/or  second
          sentences of this section  11(a)(iii),  the company (x) shall provide,
          subject to section 7(e) hereof, that such action shall apply uniformly
          to all outstanding  rights and (y) may suspend the  exercisability  of
          the rights until the expiration of the substitution period in order to
          seek any  authorization  of additional  shares,  to take any action to
          obtain  any  required   regulatory   approval  and/or  to  decide  the
          appropriate  form of  distribution  to be made  pursuant to such first
          sentence and to determine the value thereof.  in the event of any such
          suspension, the company shall issue a public announcement stating that
          the  exercisability of the rights has been temporarily  suspended,  as
          well as a public  announcement  at such time as the  suspension  is no
          longer in effect. for purposes of this section  11(a)(iii),  the value
          of the common  shares  shall be the current per share  market price of
          the common shares on the section  11(a)(ii) trigger date and the value
          of any common stock  equivalent shall be deemed to have the same value
          as the common shares on such date.

(b)  In case the Company  shall,  at any time after the date of this  Agreement,
     fix a record date for the  issuance  of rights,  options or warrants to all
     holders of Preferred  Shares  entitling such holders (for a period expiring
     within  forty-five  (45) calendar days after such record date) to subscribe
     for or  purchase  Preferred  Shares  or  Equivalent  Shares  or  securities
     convertible into Preferred Shares or Equivalent Shares at a price per share
     (or having a conversion  price per share,  if a security  convertible  into
     Preferred Shares or Equivalent Shares) less than the then Current Per Share



     Market Price of the Preferred  Shares or  Equivalent  Shares on such record
     date,  then,  in each such case,  the Exercise  Price to be in effect after
     such record date shall be determined by  multiplying  the Exercise Price in
     effect  immediately prior to such record date by a fraction,  the numerator
     of which shall be the number of Preferred Shares and Equivalent  Shares (if
     any)  outstanding on such record date, plus the number of Preferred  Shares
     or  Equivalent  Shares,  as the case may be, which the  aggregate  offering
     price of the total number of Preferred Shares or Equivalent  Shares, as the
     case  may be,  to be  offered  or  issued  (and/or  the  aggregate  initial
     conversion  price of the  convertible  securities  to be offered or issued)
     would purchase at such current market price,  and the  denominator of which
     shall be the  number of  Preferred  Shares and  Equivalent  Shares (if any)
     outstanding  on such record date,  plus the number of additional  Preferred
     Shares  or  Equivalent  Shares,  as the  case  may be,  to be  offered  for
     subscription or purchase (or into which the convertible securities so to be
     offered are initially  convertible);  provided,  however,  that in no event
     shall the  consideration  to be paid upon the exercise of one Right be less
     than the  aggregate par value of the shares of capital stock of the Company
     issuable upon exercise of one Right. In case such subscription price may be
     paid in a consideration  part or all of which shall be in a form other than
     cash, the value of such consideration  shall be as determined in good faith
     by the Board of  Directors,  whose  determination  shall be  described in a
     statement  filed with the  Rights  Agent and shall be binding on the Rights
     Agent and the holders of the Rights. Preferred Shares and Equivalent Shares
     owned  by or held  for the  account  of the  Company  shall  not be  deemed
     outstanding for the purpose of any such computation.  Such adjustment shall
     be made successively whenever such a record date is fixed, and in the event
     that such rights, options or warrants are not so issued, the Exercise Price
     shall be adjusted to be the Exercise Price which would then be in effect if
     such record date had not been fixed.

(c)  In case the Company  shall,  at any time after the date of this  Agreement,
     fix a record  date for the making of a  distribution  to all holders of the
     Preferred Shares or of any class or series of Equivalent  Shares (including
     any such  distribution made in connection with a consolidation or merger in
     which the Company is the continuing or surviving  corporation) of evidences
     of indebtedness or assets (other than a regular quarterly cash dividend, if
     any, or a dividend  payable in Preferred  Shares) or  subscription  rights,
     options or warrants  (excluding those referred to in Section 11(b)),  then,
     in each such case,  the  Exercise  Price to be in effect  after such record
     date  shall be  determined  by  multiplying  the  Exercise  Price in effect
     immediately prior to such record date by a fraction, the numerator of which
     shall be the Current  Per Share  Market  Price of a  Preferred  Share or an
     Equivalent  Share on such  record  date,  less the fair  market  value  per
     Preferred  Share or  Equivalent  Share (as  determined in good faith by the
     Board of Directors,  whose  determination shall be described in a statement
     filed  with the  Rights  Agent)  of the  portion  of the  cash,  assets  or
     evidences of  indebtedness  so to be  distributed  or of such  subscription
     rights or warrants  applicable to a Preferred Share or Equivalent Share, as
     the case may be, and the  denominator  of which  shall be such  Current Per
     Share Market Price of a Preferred Share or Equivalent  Share on such record
     date;  provided,  however,  that in no event shall the  consideration to be
     paid upon the exercise of one Right be less than the aggregate par value of
     the shares of capital  stock of the Company  issuable  upon exercise of one



     Right. Such adjustments  shall be made successively  whenever such a record
     date is fixed, and in the event that such  distribution is not so made, the
     Exercise  Price shall be adjusted to be the Exercise Price which would have
     been in effect if such record date had not been fixed.

(d)  Anything  herein to the  contrary  notwithstanding,  no  adjustment  in the
     Exercise Price shall be required  unless such  adjustment  would require an
     increase  or  decrease  of at least  1% in the  Exercise  Price;  provided,
     however, that any adjustments which by reason of this Section 11(d) are not
     required to be made shall be carried  forward and taken into account in any
     subsequent adjustment. All calculations under this Section 11 shall be made
     to the nearest cent or to the nearest  ten-thousandth  of a Common Share or
     other share or one hundred-thousandth of a Preferred Share, as the case may
     be.   Notwithstanding  the  first  sentence  of  this  Section  11(d),  any
     adjustment  required  by this  Section  11 shall be made no later  than the
     earlier  of (i)  three  (3) years  from the date of the  transaction  which
     requires such adjustment or (ii) the Expiration Date.

(e)  If as a result of an  adjustment  made  pursuant to Section  11(a) or 13(a)
     hereof, the holder of any Right thereafter  exercised shall become entitled
     to receive  any  shares of  capital  stock  other  than  Preferred  Shares,
     thereafter  the number of such other shares so receivable  upon exercise of
     any Right and, if required, the Exercise Price thereof, shall be subject to
     adjustment from time to time in a manner and on terms as nearly  equivalent
     as  practicable  to the  provisions  with respect to the  Preferred  Shares
     contained in Sections 11(a),  11(b),  11(c),  11(d),  11(g),  11(h), 11(i),
     11(j),  11(k) and 11(l), and the provisions of Sections 7, 9, 10, 13 and 14
     with respect to the Preferred  Shares shall apply on like terms to any such
     other shares.

(f)  All Rights  originally  issued by the Company  subsequent to any adjustment
     made to the Exercise Price  hereunder shall evidence the right to purchase,
     at  the  adjusted  Exercise  Price,  the  number  of  one-thousandths  of a
     Preferred  Share  purchasable  from time to time hereunder upon exercise of
     the Rights, all subject to further adjustment as provided herein.

(g)  Unless the Company shall have exercised its election as provided in Section
     11(h),  upon  each  adjustment  of the  Exercise  Price as a result  of the
     calculations  made  in  Section  11(b)  and  (c),  each  Right  outstanding
     immediately  prior  to the  making  of  such  adjustment  shall  thereafter
     evidence the right to purchase, at the adjusted Exercise Price, that number
     of Preferred Shares (calculated to the nearest one  hundred-thousandth of a
     share)  obtained  by (i)  multiplying  (x) the number of  Preferred  Shares
     covered  by a  Right  immediately  prior  to  this  adjustment,  by (y) the
     Exercise  Price  in  effect  immediately  prior to such  adjustment  of the
     Exercise  Price,  and (ii) dividing the product so obtained by the Exercise
     Price in effect immediately after such adjustment of the Exercise Price.

(h)  The  Company  may  elect on or  after  the  date of any  adjustment  of the
     Exercise Price as a result of the calculations made in Section 11(b) or (c)
     to adjust the number of Rights,  in substitution  for any adjustment in the
     number of Preferred Shares  purchasable upon the exercise of a Right.  Each
     of the Rights  outstanding  after such  adjustment  of the number of Rights
     shall be exercisable for the number of one-thousandths of a Preferred Share
     for which a Right was  exercisable  immediately  prior to such  adjustment.
     Each Right held of record prior to such  adjustment of the number of Rights
     shall  become  that  number  of  Rights  (calculated  to  the  nearest  one
     hundred-thousandth)  obtained  by  dividing  the  Exercise  Price in effect
     immediately prior to adjustment of the Exercise Price by the Exercise Price
     in effect  immediately  after adjustment of the Exercise Price. The Company



     shall make a public  announcement  of its  election to adjust the number of
     Rights, indicating the record date for the adjustment, and, if known at the
     time, the amount of the adjustment to be made.  This record date may be the
     date on which the Exercise Price is adjusted or any day thereafter, but, if
     the Rights  Certificates have been issued,  shall be at least ten (10) days
     later than the date of the public announcement. If Rights Certificates have
     been issued,  upon each adjustment of the number of Rights pursuant to this
     Section 11(h),  the Company shall, as promptly as practicable,  cause to be
     distributed to holders of record of Rights Certificates on such record date
     Rights  Certificates   evidencing,   subject  to  Section  14  hereof,  the
     additional  Rights to which such  holders  shall be entitled as a result of
     such  adjustment,  or, at the  option  of the  Company,  shall  cause to be
     distributed to such holders of record in  substitution  and replacement for
     the  Rights  Certificates  held  by  such  holders  prior  to the  date  of
     adjustment,  and upon surrender  thereof,  if required by the Company,  new
     Rights  Certificates  evidencing all the Rights to which such holders shall
     be entitled after such adjustment. Rights Certificates so to be distributed
     shall be issued,  executed  and  countersigned  in the manner  provided for
     herein (and may bear, at the option of the Company,  the adjusted  Exercise
     Price)  and shall be  registered  in the names of the  holders of record of
     Rights   Certificates   on  the  record  date   specified   in  the  public
     announcement.

(i)  Irrespective  of any  adjustment  or  change in the  Exercise  Price or the
     number of Preferred  Shares  issuable upon the exercise of the Rights,  the
     Rights  Certificates  theretofore  and  thereafter  issued may  continue to
     express the Exercise Price per one  one-thousandth of a Preferred Share and
     the number of  one-thousandths of a Preferred Share which were expressed in
     the initial Rights Certificates issued hereunder.

(j)  Before  taking  any action  that would  cause an  adjustment  reducing  the
     Exercise  Price  below the par or stated  value,  if any,  of the number of
     one-thousandths  of a Preferred Share issuable upon exercise of the Rights,
     the Company  shall take any  corporate  action which may, in the opinion of
     its counsel, be necessary in order that the Company may validly and legally
     issue as fully paid and nonassessable shares such number of one-thousandths
     of a Preferred Share at such adjusted Exercise Price.

(k)  In any case in which this Section 11 shall  require that an  adjustment  in
     the  Exercise  Price be made  effective as of a record date for a specified
     event,  the Company may elect to defer until the  occurrence  of such event
     the issuing to the holder of any Right  exercised after such record date of
     the number of  one-thousandths of a Preferred Share and other capital stock
     or securities of the Company,  if any, issuable upon such exercise over and
     above the number of  one-thousandths of a Preferred Share and other capital
     stock or securities of the Company,  if any, issuable upon such exercise on
     the  basis of the  Exercise  Price  in  effect  prior  to such  adjustment;
     provided, however, that the Company shall deliver to such holder a due bill
     or other appropriate  instrument  evidencing such holder's right to receive
     such additional shares (fractional or otherwise) upon the occurrence of the
     event requiring such adjustment.


(l)  Anything in this Section 11 to the contrary  notwithstanding,  prior to the
     Distribution Date, the Company shall be entitled to make such reductions in
     the Exercise Price, in addition to those adjustments  expressly required by
     this Section 11, as and to the extent that it in its sole discretion  shall
     determine  to  be  advisable  in  order  that  any  (i)   consolidation  or
     subdivision  of the Preferred or Common  Shares,  (ii) issuance  wholly for
     cash of any  Preferred  or Common  Shares at less than the  current  market
     price,  (iii)  issuance  wholly for cash of Preferred  or Common  Shares or
     securities  which by their terms are convertible  into or exchangeable  for
     Preferred or Common Shares, (iv) stock dividends or (v) issuance of rights,
     options or warrants  referred to in this Section 11,  hereafter made by the
     Company to holders of its  Preferred or Common  Shares shall not be taxable
     to such stockholders.

(m)  The Company covenants and agrees that, after the Distribution Date, it will
     not,  except as permitted by Sections 23, 24 or 27 hereof,  take (or permit
     to be  taken)  any  action  if at the  time  such  action  is  taken  it is
     reasonably  foreseeable  that such action will  diminish  substantially  or
     otherwise eliminate the benefits intended to be afforded by the Rights.

(n)  In the event the Company shall at any time after the date of this Agreement
     (A) declare a dividend on the Common Shares payable in Common  Shares,  (B)
     subdivide the outstanding Common Shares, (C) combine the outstanding Common
     Shares (by  reverse  stock  split or  otherwise)  into a smaller  number of
     Common  Shares,  or  (D)  issue  any  shares  of  its  capital  stock  in a
     reclassification of the Common Shares (including any such  reclassification
     in connection  with a  consolidation  or merger in which the Company is the
     continuing or surviving  corporation),  then, in each such event, except as
     otherwise  provided in this Section 11(a) and Section 7(e) hereof: (1) each
     Common Share (or shares of capital stock issued in such reclassification of
     the Common Shares) outstanding  immediately  following such time shall have
     associated  with it the number of Rights as were associated with one Common
     Share immediately prior to the occurrence of the event described in clauses
     (A)-(D)  above;  (2) the Exercise Price in effect at the time of the record
     date  for  such  dividend  or of the  effective  date of such  subdivision,
     combination  or  reclassification  shall be adjusted  so that the  Exercise
     Price  thereafter  shall  equal the  result  obtained  by  multiplying  the
     Exercise Price in effect immediately prior to such time by a fraction,  the
     numerator of which shall be the total number of Common  Shares  outstanding
     immediately  prior to the event described in clauses (A)-(D) above, and the
     denominator of which shall be the total number of Common Shares outstanding
     immediately after such event; provided, however, that in no event shall the
     consideration  to be paid upon the  exercise  of one Right be less than the
     aggregate par value of the shares of capital stock of the Company  issuable
     upon  exercise of such Right;  and (3) the number of  one-thousandths  of a
     Preferred  Share (or shares of such other capital stock)  issuable upon the
     exercise of each Right  outstanding after such event shall equal the number
     of one-  thousandths of a Preferred  Share (or shares of such other capital
     stock) as were issuable with respect to one Right immediately prior to such
     event. Each Common Share that shall become  outstanding after an adjustment
     has been made pursuant to this Section 11(n) shall have  associated with it
     the number of Rights,  exercisable at the Exercise Price and for the number
     of  one-thousandths  of a Preferred  Share (or shares of such other capital
     stock) as one Common Share has associated with it immediately following the
     adjustment  made pursuant to this Section  11(n).  If an event occurs which
     would  require an  adjustment  under both this  Section  11(n) and  Section
     11(a)(ii) hereof,  the adjustment  provided for in this Section 11(n) shall
     be in  addition  to, and shall be made prior to,  any  adjustment  required
     pursuant to Section 11(a)(ii) hereof.


Section 12 Certificate of Adjusted Exercise Price or Number of Shares.

     Whenever  an  adjustment  is made as provided in Sections 11 and 13 hereof,
the  Company  shall  promptly  (a)  prepare a  certificate  setting  forth  such
adjustment and a brief  statement of the facts  accounting for such  adjustment,
(b) file with the Rights Agent and with each  transfer  agent for the  Preferred
Shares a copy of such  certificate  and (c) mail a brief summary thereof to each
holder  of  a  Rights   Certificate  in  accordance   with  Section  26  hereof.
Notwithstanding the foregoing sentence,  the failure of the Company to make such
certification  or give  such  notice  shall  not  affect  the  validity  of such
adjustment or the force or effect of the  requirement for such  adjustment.  The
Rights Agent shall be fully protected in relying on any such  certificate and on
any  adjustment  contained  therein and shall not be deemed to have knowledge of
such adjustment unless and until it shall have received such certificate.

Section 13 Consolidation, Merger or Sale or Transfer of Assets or Earning Power.

(a)  In the event that, following a Triggering Event, directly or indirectly:

     (i)  the company shall  consolidate with, or merge with and into, any other
          person  (other  than a  wholly-owned  subsidiary  of the  company in a
          transaction  the principal  purpose of which is to change the state of
          incorporation  of the company and which  complies  with section  11(m)
          hereof);

     (ii) any person shall consolidate with the company,  or merge with and into
          the company  and the  company  shall be the  continuing  or  surviving
          corporation of such  consolidation  or merger and, in connection  with
          such merger, all or part of the common shares shall be changed into or
          exchanged  for stock or other  securities  of any other person (or the
          company); or

     (iii)the company  shall sell or  otherwise  transfer (or one or more of its
          subsidiaries  shall  sell  or  otherwise  transfer),  in one  or  more
          transactions,  assets or earning power  aggregating 50% or more of the
          assets or earning power of the company and its subsidiaries  (taken as
          a whole) to any other person or persons (other than the company or one
          or more of its wholly owned  subsidiaries in one or more transactions,
          each of which  individually (and together) complies with section 11(m)
          hereof),then, concurrent with and in each such case,

          (A)  each  holder of a Right  (except  as  provided  in  Section  7(e)
               hereof)  shall  thereafter  have the right to  receive,  upon the
               exercise  thereof at a price  equal to the Total  Exercise  Price
               applicable  immediately prior to the occurrence of the Section 13
               Event in accordance with the terms of this Agreement, such number
               of validly authorized and issued,  fully paid,  nonassessable and
               freely   tradable  Common  Shares  of  the  Principal  Party  (as
               hereinafter defined), free of any liens, encumbrances,  rights of
               first refusal or other adverse  claims,  as shall be equal to the
               result  obtained by dividing such Total  Exercise Price by 50% of
               the Current Per Share Market  Price of the Common  Shares of such
               Principal  Party on the date of  consummation  of such Section 13
               Event, provided,  however, that the Exercise Price and the number
               of  Common  Shares of such  Principal  Party so  receivable  upon



               exercise  of a Right  shall be subject to further  adjustment  as
               appropriate in accordance with Section 11(e) hereof;

          (B)  such  Principal  Party shall  thereafter be liable for, and shall
               assume,  by virtue of such Section 13 Event,  all the obligations
               and duties of the Company pursuant to this Agreement;

          (C)  the term  "Company"  shall  thereafter be deemed to refer to such
               Principal  Party,  it  being   specifically   intended  that  the
               provisions  of  Section  11  hereof  shall  apply  only  to  such
               Principal  Party  following the first  occurrence of a Section 13
               Event;

          (D)  such Principal  Party shall take such steps  (including,  but not
               limited to, the reservation of a sufficient  number of its Common
               Shares)  in  connection   with  the   consummation  of  any  such
               transaction  as may be  necessary  to ensure that the  provisions
               hereof shall  thereafter be  applicable,  as nearly as reasonably
               may be, in relation to its Common Shares  thereafter  deliverable
               upon the exercise of the Rights; and

          (E)  upon the subsequent occurrence of any consolidation, merger, sale
               or  transfer  of assets  or other  extraordinary  transaction  in
               respect of such  Principal  Party,  each  holder of a Right shall
               thereupon  be entitled to receive,  upon  exercise of a Right and
               payment of the Total  Exercise  Price as provided in this Section
               13(a),  such cash,  shares,  rights,  warrants and other property
               which such  holder  would have been  entitled to receive had such
               holder, at the time of such transaction,  owned the Common Shares
               of the Principal Party receivable upon the exercise of such Right
               pursuant to this Section 13(a),  and such  Principal  Party shall
               take such steps  (including,  but not limited to,  reservation of
               shares of stock) as may be  necessary  to permit  the  subsequent
               exercise of the Rights in  accordance  with the terms  hereof for
               such cash, shares, rights, warrants and other property.

          (F)  For purposes  hereof,  the "earning power" of the Company and its
               Subsidiaries  shall be  determined in good faith by the Company's
               Board of Directors on the basis of the operating earnings of each
               business operated by the Company and its Subsidiaries  during the
               three fiscal years preceding the date of such  determination (or,
               in the case of any  business  not  operated by the Company or any
               Subsidiary  during three full fiscal years  preceding  such date,
               during the period such  business  was  operated by the Company or
               any Subsidiary).

(b)  For purposes of this Agreement, the term "PRINCIPAL PARTY" shall mean:

     (i)  in the case of any  transaction  described  in  clause  (i) or (ii) of
          section  13(a)  hereof:  (a)  the  person  that is the  issuer  of the
          securities  into which the common  shares are converted in such merger
          or  consolidation,  or,  if there is more  than one such  issuer,  the
          issuer the common shares of which have the greatest  aggregate  market
          value of shares  outstanding,  or (b) if no securities  are so issued,
          (x) the person that is the other  party to the merger,  if such person



          survives said merger,  or, if there is more than one such person,  the
          person the common shares of which have the greatest  aggregate  market
          value of shares  outstanding  or (y) if the  person  that is the other
          party to the merger does not survive the merger,  the person that does
          survive the merger  (including  the company if it survives) or (z) the
          person resulting from the consolidation; and

     (ii) in the case of any  transaction  described  in clause (iii) of section
          13(a)  hereof,  the person that is the party  receiving  the  greatest
          portion of the assets or earning  power  transferred  pursuant to such
          transaction  or  transactions,  or, if more than one person  that is a
          party to such transaction or transactions receives the same portion of
          the  assets or  earning  power so  transferred  and each such  portion
          would,  were it not for  the  other  equal  portions,  constitute  the
          greatest portion of the assets or earning power so transferred,  or if
          the person  receiving  the  greatest  portion of the assets or earning
          power cannot be determined, whichever of such persons is the issuer of
          common  shares  having the greatest  aggregate  market value of shares
          outstanding; provided, however, that in any such case described in the
          foregoing  clause  (b)(i) or  (b)(ii),  if the  common  shares of such
          person  are not at such  time or have not been  continuously  over the
          preceding  12-month period registered under section 12 of the exchange
          act,  then (1) if such  person is a direct or indirect  subsidiary  of
          another  person  the  common  shares  of which  are and  have  been so
          registered,  the term  "principal  party"  shall  refer to such  other
          person, or (2) if such person is a subsidiary, directly or indirectly,
          of more than one person,  the common shares of which are and have been
          so registered,  the term "principal party" shall refer to whichever of
          such  persons  is the  issuer of common  shares  having  the  greatest
          aggregate market value of shares outstanding, or (3) if such person is
          owned,  directly or  indirectly,  by a joint venture  formed by two or
          more persons that are not owned,  directly or  indirectly  by the same
          person,  the rules set forth in clauses  (1) and (2) above shall apply
          to each of the  owners  having an  interest  in the  venture as if the
          person owned by the joint  venture was a subsidiary  of both or all of
          such joint venturers,  and the principal party in each such case shall
          bear the obligations set forth in this section 13 in the same ratio as
          its interest in such person bears to the total of such interests.

(c)  The Company shall not  consummate any Section 13 Event unless the Principal
     Party shall have a sufficient  number of authorized Common Shares that have
     not been issued or reserved  for issuance to permit the exercise in full of
     the Rights in accordance  with this Section 13 and unless prior thereto the
     Company and such issuer  shall have  executed  and  delivered to the Rights
     Agent a supplemental  agreement confirming that such Principal Party shall,
     upon  consummation  of such  Section 13 Event,  assume  this  Agreement  in
     accordance  with Sections 13(a) and 13(b) hereof,  that all rights of first
     refusal or preemptive rights in respect of the issuance of Common Shares of
     such Principal Party upon exercise of outstanding  Rights have been waived,
     that there are no rights,  warrants,  instruments or securities outstanding
     or any agreements or arrangements which, as a result of the consummation of
     such  transaction,  would eliminate or substantially  diminish the benefits
     intended to be afforded by the Rights and that such  transaction  shall not
     result in a default  by such  Principal  Party  under this  Agreement,  and
     further  providing  that,  as soon as  practicable  after  the date of such
     Section 13 Event, such Principal Party will:


     (i)  prepare and file a  registration  statement  under the  securities act
          with  respect  to the  rights  and  the  securities  purchasable  upon
          exercise of the rights on an appropriate form, use its best efforts to
          cause  such  registration  statement  to become  effective  as soon as
          practicable  after such filing and use its best  efforts to cause such
          registration  statement to remain  effective (with a prospectus at all
          times  meeting  the  requirements  of the  securities  act)  until the
          expiration date, and similarly comply with applicable state securities
          laws;

     (ii) use its best  efforts to list (or  continue the listing of) the rights
          and the  securities  purchasable  upon  exercise  of the  rights  on a
          national securities  exchange or to meet the eligibility  requirements
          for  quotation  on nasdaq and list (or  continue  the  listing of) the
          rights and the securities  purchasable  upon exercise of the rights on
          nasdaq; and

     (iii)deliver to holders of the rights historical  financial  statements for
          such   principal   party  which  comply  in  all  respects   with  the
          requirements for registration on form 10 (or any successor form) under
          the exchange act.

     In the event that at any time after the  occurrence  of a Triggering  Event
some or all of the  Rights  shall  not  have  been  exercised  at the  time of a
transaction  described in this Section 13, the Rights which have not theretofore
been  exercised  shall  thereafter  be  exercisable  in the manner  described in
Section  13(a)  (without  taking into account any prior  adjustment  required by
Section 11(a)(ii)).

(d)  In case the  "Principal  Party" for  purposes of Section  13(b)  hereof has
     provision in any of its  authorized  securities  or in its  certificate  of
     incorporation  or  by-laws  or other  instrument  governing  its  corporate
     affairs,  which  provision  would  have  the  effect  of (i)  causing  such
     Principal  Party to issue  (other  than to  holders of Rights  pursuant  to
     Section  13  hereof),  in  connection  with,  or as a  consequence  of, the
     consummation of a Section 13 Event,  Common Shares or Equivalent  Shares of
     such  Principal  Party at less than the then Current Per Share Market Price
     thereof or securities  exercisable for, or convertible  into, Common Shares
     or Equivalent Shares of such Principal Party at less than such then Current
     Per Share Market Price, or (ii) providing for any special  payment,  tax or
     similar  provision in connection  with the issuance of the Common Shares of
     such Principal Party pursuant to the provisions of Section 13 hereof, then,
     in such event, the Company hereby agrees with each holder of Rights that it
     shall not consummate any such transaction  unless prior thereto the Company
     and such  Principal  Party shall have  executed and delivered to the Rights
     Agent a supplemental  agreement providing that the provision in question of
     such Principal Party shall have been canceled,  waived or amended,  or that
     the  authorized  securities  shall  be  redeemed,  so that  the  applicable
     provision  will have no effect in connection  with or as a consequence  of,
     the consummation of the proposed transaction.

(e)  The Company  covenants  and agrees that it shall not, at any time after the
     Distribution  Date,  effect or permit to occur any Section 13 Event, if (i)
     at the time or  immediately  after  such  Section  13 Event  there  are any
     rights,   warrants  or  other  instruments  or  securities  outstanding  or
     agreements  in effect  which  would  substantially  diminish  or  otherwise
     eliminate  the benefits  intended to be afforded by the Rights,  (ii) prior
     to,  simultaneously  with or immediately  after such Section 13 Event,  the
     stockholders of the Person who constitutes, or



     would  constitute,  the  "Principal  Party" for  purposes of Section  13(b)
     hereof shall have received a  distribution  of Rights  previously  owned by
     such Person or any of its  Affiliates  or  Associates  or (iii) the form or
     nature of  organization  of the Principal Party would preclude or limit the
     exercisability of the Rights.

(f)  Notwithstanding  anything in this  Agreement  to the  contrary,  Section 13
     shall not be applicable to a transaction  described in clauses (i) and (ii)
     of Section 13(a) if: (i) such  transaction is consummated  with a Person or
     Persons who  acquired  Common  Shares  pursuant to a Permitted  Offer (or a
     wholly-owned  Subsidiary of any such Person or Persons); (ii) the price per
     share of Common  Shares  offered in such  transaction  is not less than the
     price per share of Common Shares paid to all holders of Common Shares whose
     shares were purchased  pursuant to such Permitted Offer; and (iii) the form
     of  consideration  being offered to the remaining  holders of Common Shares
     pursuant to such  transaction is the same form as the form of consideration
     paid  pursuant  to such  Permitted  Offer.  Upon  consummation  of any such
     transaction  contemplated by this Section 13(f), all Rights hereunder shall
     expire.

(g)  The  provisions  of this  Section 13 shall  similarly  apply to  successive
     mergers or consolidations or sales or other transfers.

Section 14 Fractional Rights and Fractional Shares.

(a)  The  Company  shall  not be  required  to issue  fractions  of Rights or to
     distribute Rights Certificates which evidence fractional Rights. In lieu of
     such fractional  Rights,  there shall be paid to the registered  holders of
     the Rights  Certificates  with regard to which such fractional Rights would
     otherwise be issuable,  an amount in cash equal to the same fraction of the
     current  market  value of a whole  Right.  For the purposes of this Section
     14(a), the current market value of a whole Right shall be the closing price
     of the Rights for the  Trading Day  immediately  prior to the date on which
     such fractional  Rights would have been otherwise  issuable,  as determined
     pursuant to the second sentence of Section 1(k) hereof.

(b)  The Company  shall not be required to issue  fractions of Preferred  Shares
     (other than fractions that are integral  multiples of one one-thousandth of
     a  Preferred   Share)  upon   exercise  of  the  Rights  or  to  distribute
     certificates  which  evidence  fractional   Preferred  Shares  (other  than
     fractions that are integral  multiples of one one-thousandth of a Preferred
     Share). Interests in fractions of Preferred Shares in integral multiples of
     one  one-thousandth  of a  Preferred  Share  may,  at the  election  of the
     Company,  be evidenced by depositary  receipts,  pursuant to an appropriate
     agreement  between the Company and a depositary  selected by it;  provided,
     that such  agreement  shall  provide  that the  holders of such  depositary
     receipts  shall have all the rights,  privileges  and  preferences to which
     they are entitled as beneficial owners of the Preferred Shares  represented
     by such depositary  receipts.  In lieu of fractional  Preferred Shares that
     are not integral  multiples of one one-thousandth of a Preferred Share, the
     Company shall pay to the registered  holders of Rights  Certificates at the
     time such Rights are  exercised as herein  provided an amount in cash equal
     to the same fraction of the current market value of a Preferred  Share. For
     purposes of this  Section  14(b),  the current  market value of a Preferred
     Share shall be one thousand  times the closing  price of a Common Share (as
     determined  pursuant to the second sentence of Section 1(k) hereof) for the
     Trading Day immediately prior to the date of such exercise.


(c)  The Company shall not be required to issue fractions of Common Shares or to
     distribute  certificates  which evidence  fractional Common Shares upon the
     exercise or exchange of Rights.  In lieu of such fractional  Common Shares,
     the Company shall pay to the registered  holders of Rights  Certificates at
     the time such  Rights are  exercised  as herein  provided an amount in cash
     equal to the same  fraction of the current  market value of a Common Share.
     For purposes of this Section  14(c),  the current  market value of a Common
     Share shall be the closing price of a Common Share (as determined  pursuant
     to the  second  sentence  of  Section  1(k)  hereof)  for the  Trading  Day
     immediately prior to the date of such exercise.

(d)  The holder of a Right by the acceptance of the Right  expressly  waives his
     or her right to receive  any  fractional  Rights or any  fractional  shares
     (other than fractions that are integral  multiples of one one-thousandth of
     a Preferred Share) upon exercise of a Right.

Section 15 Rights of Action.

     All rights of action in respect of this Agreement,  excepting the rights of
action  given to the Rights  Agent  under  Section 18 hereof,  are vested in the
respective  registered  holders of the Rights  Certificates  (and,  prior to the
Distribution  Date,  the  registered  holders  of the  Common  Shares);  and any
registered holder of any Rights Certificate (or, prior to the Distribution Date,
of the Common Shares),  without the consent of the Rights Agent or of the holder
of any other Rights  Certificate  (or,  prior to the  Distribution  Date, of the
Common  Shares),  may, in his or her own behalf and for his or her own  benefit,
enforce,  and may institute and maintain any suit, action or proceeding  against
the  Company to  enforce,  or  otherwise  act in respect of, his or her right to
exercise the Rights evidenced by such Rights  Certificate in the manner provided
in such Rights Certificate and in this Agreement. Without limiting the foregoing
or  any  remedies  available  to  the  holders  of  Rights,  it is  specifically
acknowledged that the holders of Rights would not have an adequate remedy at law
for any breach of this Agreement and will be entitled to specific performance of
the  obligations  under,  and  injunctive  relief  against  actual or threatened
violations of, the obligations of any Person subject to this Agreement.

Section 16 Agreement of Rights Holders.

     Every holder of a Right,  by accepting  the same,  consents and agrees with
the Company and the Rights Agent and with every other holder of a Right that:

(a)  prior to the  Distribution  Date, the Rights will be  transferable  only in
     connection with the transfer of the Common Shares;

(b)  after the Distribution Date, the Rights  Certificates are transferable only
     on the registry  books of the Rights Agent if  surrendered at the principal
     office or offices of the Rights Agent  designated for such  purposes,  duly
     endorsed or  accompanied  by a proper  instrument  of transfer and with the
     appropriate forms and certificates fully executed; and


(c)  subject to Sections 6(a) and 7(f) hereof,  the Company and the Rights Agent
     may deem and treat the  person in whose name the  Rights  Certificate  (or,
     prior to the Distribution  Date, the associated Common Shares  certificate)
     is  registered as the absolute  owner  thereof and of the Rights  evidenced
     thereby  (notwithstanding  any  notations  of  ownership  or writing on the
     Rights  Certificates or the associated  Common Shares  certificate  made by
     anyone  other  than the  Company  or the  Rights  Agent)  for all  purposes
     whatsoever,  and neither the Company nor the Rights Agent shall be affected
     by any notice to the contrary.

Section 17 Rights Certificate Holder Not Deemed a Stockholder.

     No holder,  as such, of any Rights  Certificate  shall be entitled to vote,
receive dividends or be deemed for any purpose to be the holder of the Preferred
Shares or any other  securities of the Company which may at any time be issuable
on the exercise of the Rights represented  thereby, nor shall anything contained
herein or in any Rights  Certificate  be  construed to confer upon the holder of
any  Rights  Certificate,  as such,  any of the rights of a  stockholder  of the
Company or any right to vote for the  election of  directors  or upon any matter
submitted to stockholders at any meeting thereof, or to give or withhold consent
to any  corporate  action,  or to receive  notice of meetings  or other  actions
affecting  stockholders (except as provided in Section 25 hereof), or to receive
dividends  or  subscription  rights,  or  otherwise,  until  the Right or Rights
evidenced by such Rights  Certificate  shall have been  exercised in  accordance
with the provisions hereof.

Section 18 Concerning the Rights Agent.

(a)  The Company agrees to pay to the Rights Agent  reasonable  compensation for
     all services  rendered by it hereunder and, from time to time, on demand of
     the Rights  Agent,  its  reasonable  expenses  and  counsel  fees and other
     disbursements   incurred  in  the  administration  and  execution  of  this
     Agreement and the exercise and  performance  of its duties  hereunder.  The
     Company  also  agrees to  indemnify  the Rights  Agent for,  and to hold it
     harmless  against,  any  loss,  liability  or  expense,   incurred  without
     negligence,  bad  faith or  willful  misconduct  on the part of the  Rights
     Agent,  for anything done or omitted by the Rights Agent in connection with
     the acceptance and  administration  of this Agreement,  including the costs
     and expenses of defending  against any claim of liability in the  premises.
     In no event  will  the  Rights  Agent  be  liable  for  special,  indirect,
     incidental or consequential loss or damage of any kind whatsoever,  even if
     the  Rights  Agent  has been  advised  of the  possibility  of such loss or
     damage.

(b)  The Rights Agent shall be protected and shall incur no liability for, or in
     respect of any action taken,  suffered or omitted by it in connection with,
     its   administration   of  this  Agreement  in  reliance  upon  any  Rights
     Certificate or certificate for the Preferred Shares or Common Shares or for
     other  securities  of the Company,  instrument  of  assignment or transfer,
     power of  attorney,  endorsement,  affidavit,  letter,  notice,  direction,
     consent,  certificate,  statement  or other  paper or  document  reasonably
     believed  by  it to be  genuine  and  to be  signed,  executed  and,  where
     necessary,  verified or acknowledged,  by the proper Person or Persons,  or
     otherwise upon the advice of counsel as set forth in Section 20 hereof.


Section 19 Merger or Consolidation or Change of Name of Rights Agent.

(a)  Any corporation  into which the Rights Agent or any successor  Rights Agent
     may be  merged or with  which it may be  consolidated,  or any  corporation
     resulting from any merger or consolidation to which the Rights Agent or any
     successor  Rights Agent shall be a party, or any corporation  succeeding to
     the corporate  trust  business of the Rights Agent or any successor  Rights
     Agent,  shall be the  successor  to the Rights  Agent under this  Agreement
     without the execution or filing of any paper or any further act on the part
     of any of the parties  hereto;  provided,  however,  that such  corporation
     would be eligible  for  appointment  as a successor  Rights Agent under the
     provisions of Section 21 hereof.  In case at the time such successor Rights
     Agent shall  succeed to the agency  created by this  Agreement,  any of the
     Rights  Certificates shall have been  countersigned but not delivered,  any
     such  successor  Rights  Agent  may  adopt  the   countersignature  of  the
     predecessor   Rights  Agent  and  deliver  such  Rights   Certificates   so
     countersigned;  and in case at that  time  any of the  Rights  Certificates
     shall  not  have  been  countersigned,   any  successor  Rights  Agent  may
     countersign such Rights  Certificates either in the name of the predecessor
     Rights Agent or in the name of the successor  Rights Agent; and in all such
     cases such Rights  Certificates  shall have the full force  provided in the
     Rights Certificates and in this Agreement.

(b)  In case at any time the name of the Rights  Agent  shall be changed  and at
     such time any of the Rights  Certificates shall have been countersigned but
     not delivered,  the Rights Agent may adopt the  countersignature  under its
     prior name and deliver Rights Certificates so countersigned; and in case at
     that time any of the Rights Certificates shall not have been countersigned,
     the Rights Agent may  countersign  such Rights  Certificates  either in its
     prior  name or in its  changed  name;  and in all such  cases  such  Rights
     Certificates shall have the full force provided in the Rights  Certificates
     and in this Agreement.

Section 20 Duties of Rights Agent.

     The Rights  Agent  undertakes  the duties and  obligations  imposed by this
Agreement upon the following terms and  conditions,  by all of which the Company
and the holders of Rights  Certificates,  by their acceptance thereof,  shall be
bound:

(a)  The Rights Agent may consult with legal  counsel (who may be legal  counsel
     for the Company),  and the written  advice or opinion of such counsel shall
     be full and complete authorization and protection to the Rights Agent as to
     any action taken or omitted by it in good faith and in accordance with such
     written advice or opinion.

(b)  Whenever in the  performance  of its duties under this Agreement the Rights
     Agent  shall  deem it  necessary  or  desirable  that  any  fact or  matter
     (including,  without  limitation,  the identity of any Acquiring Person and
     the  determination  of  Current  Per  Share  Market  Price)  be  proved  or
     established  by the  Company  prior  to  taking  or  suffering  any  action
     hereunder, such fact or matter (unless other evidence in respect thereof be
     herein specifically prescribed) may be deemed to be conclusively proved and
     established  by a  certificate  signed  by any one of the  Chairman  of the
     Board, the Chief Executive Officer, the President,  any Vice President, the
     Chief Financial  Officer,  the Secretary or any Assistant  Secretary of the
     Company and delivered to the Rights Agent;  and such  certificate  shall be
     full  authorization to the Rights Agent for any action taken or suffered in



     good faith by it under the  provisions  of this  Agreement in reliance upon
     such certificate.

(c)  The Rights  Agent  shall be liable  hereunder  to the Company and any other
     Person only for its own negligence, bad faith or willful misconduct.

(d)  The  Rights  Agent  shall  not be  liable  for or by  reason  of any of the
     statements of fact or recitals contained in this Agreement or in the Rights
     Certificates (except its countersignature thereof) or be required to verify
     the same,  but all such  statements and recitals are and shall be deemed to
     have been made by the Company only.

(e)  The Rights  Agent shall not be under any  responsibility  in respect of the
     validity of this Agreement or the execution and delivery hereof (except the
     due execution  hereof by the Rights Agent) or in respect of the validity or
     execution of any Rights Certificate (except its countersignature  thereof);
     nor shall it be  responsible  for any breach by the Company of any covenant
     or condition contained in this Agreement or in any Rights Certificate;  nor
     shall it be responsible for any change in the  exercisability of the Rights
     or any adjustment in the terms of the Rights (including the manner,  method
     or amount  thereof)  provided  for in  Sections 3, 11, 13, 23 or 24, or the
     ascertaining  of the  existence of facts that would require any such change
     or adjustment  (except with respect to the exercise of Rights  evidenced by
     Rights  Certificates  after  receipt by the Rights  Agent of a  certificate
     furnished pursuant to Section 12 describing such change or adjustment); nor
     shall it by any act  hereunder  be  deemed  to make any  representation  or
     warranty as to the  authorization or reservation of any Preferred Shares to
     be issued  pursuant to this  Agreement or any Rights  Certificate  or as to
     whether any Preferred Shares will, when issued,  be validly  authorized and
     issued, fully paid and nonassessable.

(f)  The Company agrees that it will perform,  execute,  acknowledge and deliver
     or cause to be  performed,  executed,  acknowledged  and delivered all such
     further and other acts,  instruments  and  assurances as may  reasonably be
     required by the Rights  Agent for the  carrying  out or  performing  by the
     Rights Agent of the provisions of this Agreement.

(g)  The Rights Agent is hereby  authorized and directed to accept  instructions
     with respect to the performance of its duties hereunder from any one of the
     Chairman of the Board, the Chief Executive Officer, the President, any Vice
     President,  the Chief  Financial  Officer,  the  Secretary or any Assistant
     Secretary  of the  Company,  and to apply to such  officers  for  advice or
     instructions in connection with its duties,  and it shall not be liable for
     any  action  taken  or  suffered  by it in good  faith in  accordance  with
     instructions  of any such officer or for any delay in acting while  waiting
     for those  instructions.  Any  application  by the Rights Agent for written
     instructions  from the Company may, at the option of the Rights Agent,  set
     forth in writing  any action  proposed to be taken or omitted by the Rights
     Agent under this Rights  Agreement  and the date on and/or after which such
     action shall be taken or such omission shall be effective. The Rights Agent
     shall not be liable for any  action  taken by, or  omission  of, the Rights
     Agent in accordance with a proposal  included in any such application on or
     after the date specified in such application  (which date shall not be less
     than five (5)  Business  Days  after the date any  officer  of the  Company
     actually  receives  such  application,  unless any such officer  shall have
     consented in writing to an earlier date)  unless,  prior to taking any such
     action (or the effective date in the case of an omission), the Rights Agent
     shall have received  written  instructions in response to such  application
     specifying the action to be taken or omitted.


(h)  The Rights Agent and any stockholder,  director, officer or employee of the
     Rights Agent may buy, sell or deal in any of the Rights or other securities
     of the Company or become pecuniarily interested in any transaction in which
     the  Company  may be  interested,  or  contract  with or lend  money to the
     Company or  otherwise  act as fully and freely as though it were not Rights
     Agent under this Agreement.  Nothing herein shall preclude the Rights Agent
     from  acting in any other  capacity  for the Company or for any other legal
     entity.

(i)  The  Rights  Agent may  execute  and  exercise  any of the rights or powers
     hereby  vested in it or perform any duty  hereunder  either itself or by or
     through  its  attorneys  or  agents,  and the  Rights  Agent  shall  not be
     answerable or accountable  for any act,  default,  neglect or misconduct of
     any such attorneys or agents or for any loss to the Company  resulting from
     any such act, default, neglect or misconduct,  provided reasonable care was
     exercised in the selection and continued employment thereof.

(j)  No provision of this Agreement  shall require the Rights Agent to expend or
     risk its own  funds or  otherwise  incur  any  financial  liability  in the
     performance of any of its duties hereunder or in the exercise of its rights
     if there shall be reasonable  grounds for believing  that repayment of such
     funds or adequate  indemnification  against  such risk or  liability is not
     reasonably assured to it.

(k)  If, with respect to any Rights Certificate  surrendered to the Rights Agent
     for  exercise  or  transfer,  the  certificate  attached  to  the  form  of
     assignment or form of election to purchase,  as the case may be, has either
     not been completed or indicates an affirmative  response to clause 1 and/or
     2 thereof,  the Rights Agent shall not take any further action with respect
     to such requested  exercise or transfer  without first  consulting with the
     Company.

Section 21 Change of Rights Agent.

     The Rights Agent or any successor Rights Agent may resign and be discharged
from its duties  under this  Agreement  upon thirty (30) days' notice in writing
mailed to the Company and to each transfer agent of the Preferred Shares and the
Common Shares by registered or certified  mail, and to the holders of the Rights
Certificates by first-class mail. The Company may remove the Rights Agent or any
successor  Rights Agent upon thirty (30) days' notice in writing,  mailed to the
Rights Agent or successor Rights Agent, as the case may be, and to each transfer
agent of the  Preferred  Shares and the Common Shares by registered or certified
mail, and to the holders of the Rights  Certificates by first-class mail. If the
Rights Agent shall resign or be removed or shall otherwise  become  incapable of
acting,  the Company  shall  appoint a  successor  to the Rights  Agent.  If the
Company shall fail to make such appointment  within a period of thirty (30) days
after giving  notice of such removal or after it has been notified in writing of
such resignation or incapacity by the resigning or incapacitated Rights Agent or
by the holder of a Rights  Certificate (who shall, with such notice,  submit his
or her Rights  Certificate  for inspection by the Company),  then the registered
holder  of  any  Rights   Certificate  may  apply  to  any  court  of  competent
jurisdiction  for the  appointment of a new Rights Agent.  Any successor  Rights
Agent,  whether  appointed  by the  Company  or by  such  a  court,  shall  be a



corporation  organized and doing business under the laws of the United States or
of any state of the United States,  in good standing,  which is authorized under
such laws to exercise  corporate  trust or  stockholder  services  powers and is
subject to supervision  or  examination by federal or state  authority and which
has at the time of its  appointment  as  Rights  Agent a  combined  capital  and
surplus of at least $100 million. After appointment,  the successor Rights Agent
shall be vested with the same powers,  rights, duties and responsibilities as if
it had been  originally  named as Rights Agent without  further act or deed; but
the predecessor  Rights Agent shall deliver and transfer to the successor Rights
Agent any property at the time held by it hereunder, and execute and deliver any
further assurance,  conveyance, act or deed necessary for the purpose. Not later
than the effective date of any such  appointment,  the Company shall file notice
thereof in writing with the predecessor  Rights Agent and each transfer agent of
the Preferred Shares and the Common Shares, and mail a notice thereof in writing
to the registered holders of the Rights Certificates. Failure to give any notice
provided  for in this  Section 21,  however,  or any defect  therein,  shall not
affect the  legality  or validity  of the  resignation  or removal of the Rights
Agent or the appointment of the successor Rights Agent, as the case may be.

Section 22 Issuance of New Rights Certificates.

     Notwithstanding any of the provisions of this Agreement or of the Rights to
the  contrary,  the Company  may, at its option,  issue new Rights  Certificates
evidencing  Rights in such form as may be approved by its Board of  Directors to
reflect any adjustment or change in the Exercise Price and the number or kind or
class of shares or other  securities  or property  purchasable  under the Rights
Certificates  made in  accordance  with the  provisions  of this  Agreement.  In
addition, in connection with the issuance or sale of Common Shares following the
Distribution  Date and prior to the redemption or expiration of the Rights,  the
Company (a) shall,  with respect to Common  Shares so issued or sold pursuant to
the exercise of stock options or under any employee plan or  arrangement or upon
the  exercise,  conversion  or  exchange  of  other  securities  of the  Company
outstanding  at the date hereof or upon the exercise,  conversion or exchange of
securities  hereinafter issued by the Company and (b) may, in any other case, if
deemed  necessary  or  appropriate  by the  Board  of  Directors,  issue  Rights
Certificates  representing  the appropriate  number of Rights in connection with
such issuance or sale;  provided,  however,  that (i) no such Rights Certificate
shall be issued  and this  sentence  shall be null and void ab initio if, and to
the extent that, such issuance or this sentence would create a significant  risk
of or result in material  adverse tax  consequences to the Company or the Person
to whom such Rights  Certificate  would be issued or would create a  significant
risk of or result in such options' or employee plans' or  arrangements'  failing
to qualify for otherwise available special tax treatment and (ii) no such Rights
Certificate shall be issued if, and to the extent that,  appropriate  adjustment
shall otherwise have been made in lieu of the issuance thereof.

Section 23 Redemption.

(a)  The  Company  may,  at its  option  and with the  approval  of the Board of
     Directors,  at any time prior to (i) the Shares  Acquisition  Date and (ii)
     the  Final  Expiration  Date,  redeem  all but not  less  than all the then
     outstanding Rights at a redemption price of $0.01 per Right,  appropriately
     adjusted to reflect any stock split, stock dividend or similar  transaction
     occurring  after  the date  hereof  (such  redemption  price  being  herein
     referred to as the "REDEMPTION  PRICE") and the Company may, at its option,
     pay the Redemption  Price either in Common Shares (based on the Current Per
     Share  Market  Price  thereof  at the time of  redemption)  or  cash.  Such
     redemption of the Rights by the Company may be made effective at such time,



     on such basis and with such  conditions  as the Board of  Directors  in its
     sole  discretion  may  establish.  The date on which the Board of Directors
     elects  to make  the  redemption  effective  shall  be  referred  to as the
     "REDEMPTION DATE."

(b)  Immediately  upon  the  action  of the  Board  of  Directors  ordering  the
     redemption of the Rights,  evidence of which shall have been filed with the
     Rights Agent,  and without any further  action and without any notice,  the
     right to exercise the Rights will  terminate and the only right  thereafter
     of the holders of Rights  shall be to receive  the  Redemption  Price.  The
     Company shall promptly give public notice of any such redemption; provided,
     however,  that the failure to give or any defect in, any such notice  shall
     not affect the validity of such redemption.  Within ten (10) days after the
     action of the Board of Directors ordering the redemption of the Rights, the
     Company  shall give notice of such  redemption  to the Rights Agent and the
     holders of the then  outstanding  Rights by mailing such notice to all such
     holders at their last  addresses as they appear upon the registry  books of
     the Rights Agent or, prior to the Distribution  Date, on the registry books
     of the transfer agent for the Common Shares.  Any notice which is mailed in
     the manner herein provided shall be deemed given, whether or not the holder
     receives the notice.  Each such notice of redemption  will state the method
     by which the  payment of the  Redemption  Price will be made.  Neither  the
     Company nor any of its  Affiliates  or  Associates  may redeem,  acquire or
     purchase  for value any  Rights at any time in any  manner  other than that
     specifically  set forth in this  Section 23 or in  Section  24 hereof,  and
     other than in  connection  with the purchase of Common  Shares prior to the
     Distribution Date.

Section 24 Exchange.

(a)  Subject  to  applicable  laws,  rules  and  regulations,   and  subject  to
     subsection  24(c) below,  the Company  may, at its option,  by the Board of
     Directors, at any time after the occurrence of a Triggering Event, exchange
     all or part of the then outstanding and exercisable Rights (which shall not
     include  Rights that have become void pursuant to the provisions of Section
     7(e) hereof) for Common Shares at an exchange ratio of one Common Share per
     Right, appropriately adjusted to reflect any stock split, stock dividend or
     similar  transaction  occurring  after the date hereof (such exchange ratio
     being hereinafter referred to as the "EXCHANGE RATIO"). Notwithstanding the
     foregoing,  the Board of  Directors  shall not be  empowered to effect such
     exchange  at any  time  after  any  Person  (other  than the  Company,  any
     Subsidiary of the Company,  any employee benefit plan of the Company or any
     such Subsidiary, or any entity holding Common Shares for or pursuant to the
     terms of any such plan),  together with all  Affiliates  and  Associates of
     such  Person,  becomes  the  Beneficial  Owner of 50% or more of the Common
     Shares then outstanding.

(b)  Immediately upon the action of the Board of Directors ordering the exchange
     of any Rights  pursuant to subsection  24(a) of this Section 24 and without
     any  further  action and without  any  notice,  the right to exercise  such
     Rights shall  terminate  and the only right  thereafter of a holder of such
     Rights shall be to receive that number of Common Shares equal to the number
     of such Rights held by such holder  multiplied by the Exchange  Ratio.  The
     Company shall give public notice of any such exchange;  provided,  however,
     that the failure to give,  or any defect in,  such notice  shall not affect
     the validity of such exchange.  The Company shall mail a notice of any such
     exchange to all of the holders of such  Rights at their last  addresses  as
     they appear upon the registry  books of the Rights Agent.  Any notice which
     is mailed in the manner herein  provided shall be deemed given,  whether or
     not the holder receives the notice. Each such notice of exchange will state



     the method by which the  exchange  of the Common  Shares for Rights will be
     effected  and, in the event of any partial  exchange,  the number of Rights
     which will be exchanged.  Any partial  exchange  shall be effected pro rata
     based on the number of Rights  (other  than  Rights  which have become void
     pursuant to the  provisions  of Section 7(e) hereof) held by each holder of
     Rights.

(c)  In the event that there shall not be  sufficient  Common  Shares issued but
     not outstanding or authorized but unissued to permit any exchange of Rights
     as contemplated in accordance with Section 24(a),  the Company shall either
     take such action as may be necessary to authorize  additional Common Shares
     for issuance upon exchange of the Rights or alternatively, at the option of
     a majority of the Board of  Directors,  with  respect to each Right (i) pay
     cash in an amount equal to the Current Value (as hereinafter  defined),  in
     lieu of issuing Common Shares in exchange  therefor,  or (ii) issue debt or
     equity  securities  or a combination  thereof,  having a value equal to the
     Current  Value,  in lieu of issuing Common Shares in exchange for each such
     Right,  where  the  value  of such  securities  shall  be  determined  by a
     nationally  recognized investment banking firm selected by majority vote of
     the Board of Directors, or (iii) deliver any combination of cash, property,
     Common Shares and/or other  securities  having a value equal to the Current
     Value in exchange for each Right.  For purposes of this Section 24(c) only,
     the Current  Value  shall mean the product of the Current Per Share  Market
     Price of Common Shares on the date of the occurrence of the event described
     above in  subparagraph  (a),  multiplied by the number of Common Shares for
     which the Right  otherwise  would be  exchangeable if there were sufficient
     shares  available.  To the extent  that the  Company  determines  that some
     action need be taken pursuant to clauses (i), (ii) or (iii) of this Section
     24(c), the Board of Directors may temporarily suspend the exercisability of
     the  Rights  for a period of up to sixty  (60) days  following  the date on
     which the event described in Section 24(a) shall have occurred, in order to
     seek any  authorization  of  additional  Common Shares and/or to decide the
     appropriate form of distribution to be made pursuant to the above provision
     and to determine the value  thereof.  In the event of any such  suspension,
     the  Company   shall  issue  a  public   announcement   stating   that  the
     exercisability of the Rights has been temporarily suspended.

(d)  The Company shall not be required to issue fractions of Common Shares or to
     distribute certificates which evidence fractional Common Shares. In lieu of
     such  fractional  Common  Shares,  there  shall  be paid to the  registered
     holders of the Rights  Certificates  with  regard to which such  fractional
     Common Shares would  otherwise be issuable,  an amount in cash equal to the
     same  fraction  of the current  market  value of a whole  Common  Share (as
     determined pursuant to the second sentence of Section 1(k) hereof).

(e)  The Company may, at its option, by majority vote of the Board of Directors,
     at any time before any Person has become an Acquiring Person,  exchange all
     or  part  of the  then  outstanding  Rights  for  rights  of  substantially
     equivalent value, as determined reasonably and with good faith by the Board
     of Directors,  based upon the advice of one or more  nationally  recognized
     investment banking firms.


(f)  Immediately upon the action of the Board of Directors ordering the exchange
     of any Rights  pursuant to subsection  24(e) of this Section 24 and without
     any  further  action and without  any  notice,  the right to exercise  such
     Rights shall  terminate  and the only right  thereafter of a holder of such
     Rights  shall be to receive  that number of rights in exchange  therefor as
     has been determined by the Board of Directors in accordance with subsection
     24(e) above.  The Company  shall give public  notice of any such  exchange;
     provided,  however, that the failure to give, or any defect in, such notice
     shall not affect the validity of such  exchange.  The Company  shall mail a
     notice of any such  exchange  to all of the holders of such Rights at their
     last addresses as they appear upon the registry books of the transfer agent
     for the Common  Shares of the  Company.  Any notice  which is mailed in the
     manner herein  provided  shall be deemed  given,  whether or not the holder
     receives the notice.  Each such notice of exchange will state the method by
     which the exchange of the Rights will be effected.

Section 25 Notice of Certain Events.

(a)  In case the  Company  shall  propose  to  effect  or  permit  to occur  any
     Triggering Event or Section 13 Event, the Company shall give notice thereof
     to each  holder of Rights in  accordance  with  Section  26 hereof at least
     twenty  (20) days  prior to  occurrence  of such  Triggering  Event or such
     Section 13 Event.

(b)  In case any Triggering Event or Section 13 Event shall occur,  then, in any
     such case, the Company shall as soon as practicable thereafter give to each
     holder of a Rights  Certificate,  in accordance  with Section 26 hereof,  a
     notice of the  occurrence of such event,  which shall specify the event and
     the consequences of the event to holders of Rights under Sections 11(a)(ii)
     and 13 hereof.

Section 26 Notices.  Notices or demands authorized by this Agreement to be given
or made by the Rights Agent or by the holder of any Rights  Certificate to or on
the Company shall be  sufficiently  given or made if sent by  first-class  mail,
postage  prepaid,  addressed (until another address is filed in writing with the
Rights Agent) as follows:

NEUROCRINE BIOSCIENCES, INC.
3050 Science Park Road
San Diego, California  92121
Attention:  Gary A. Lyons

with a copy to:

Latham & Watkins
633 West Fifth Street, Suite 4000
Los Angeles, California  90071-2007
Attention:  Michael W. Sturrock

     Subject  to the  provisions  of  Section  21  hereof,  any notice or demand
authorized by this Agreement to be given or made by the Company or by the holder



of any Rights  Certificate to or on the Rights Agent shall be sufficiently given
or made if sent by first-class mail,  postage prepaid,  addressed (until another
address is filed in writing with the Company) as follows:

American Stock Transfer & Trust Company
6201 15th Avenue, 3rd Floor

Brooklyn, NY  11219
Attention:  Isaac Kagan

     Notices or demands  authorized by this Agreement to be given or made by the
Company or the Rights  Agent to the  holder of any Rights  Certificate  shall be
sufficiently  given  or  made  if sent by  first-class  mail,  postage  prepaid,
addressed  to such holder at the address of such holder as shown on the registry
books of the Company.

Section 27 Supplements and Amendments. Prior to the occurrence of a Distribution
Date, the Company may supplement or amend this Agreement in any respect  without
the approval of any holders of Rights and the Rights Agent shall, if the Company
so directs, execute such supplement or amendment.  From and after the occurrence
of a  Distribution  Date, the Company and the Rights Agent may from time to time
supplement or amend this Agreement without the approval of any holders of Rights
in order to (i) cure any  ambiguity,  (ii) correct or  supplement  any provision
contained  herein  which  may  be  defective  or  inconsistent  with  any  other
provisions  herein,  (iii) shorten or lengthen any time period hereunder or (iv)
to change or supplement the provisions  hereunder in any manner that the Company
may deem  necessary  or  desirable  and that  shall  not  adversely  affect  the
interests  of the  holders  of  Rights  (other  than an  Acquiring  Person or an
Affiliate or Associate of an Acquiring Person); provided, this Agreement may not
be  supplemented  or  amended  to  lengthen,  pursuant  to clause  (iii) of this
sentence,  (A) a time period relating to when the Rights may be redeemed at such
time as the Rights are not then  redeemable  or (B) any other time period unless
such  lengthening is for the purpose of protecting,  enhancing or clarifying the
rights  of,  and/or  the  benefits  to, the  holders  of Rights  (other  than an
Acquiring Person or an Affiliate or Associate of an Acquiring Person).  Upon the
delivery of a certificate from an appropriate officer of the Company that states
that the proposed  supplement  or amendment is in  compliance  with the terms of
this Section 27, the Rights Agent shall  execute such  supplement  or amendment.
Prior to the Distribution  Date, the interests of the holders of Rights shall be
deemed coincident with the interests of the holders of Common Shares.

Section 28 Successors.

     All the covenants and provisions of this Agreement by or for the benefit of
the  Company or the Rights  Agent  shall bind and inure to the  benefit of their
respective successors and assigns hereunder.

Section 29  Determinations  and Actions by the Board of Directors,  etc.

     For all purposes of this Agreement, any calculation of the number of Common
Shares outstanding at any particular time, including for purposes of determining
the particular  percentage of such outstanding Common Shares of which any Person
is the Beneficial  Owner,  shall be made in accordance with the last sentence of
Rule 13d-3(d)(1)(i) of the General Rules and Regulations under the Exchange Act.
The  Board of  Directors  shall  have  the  exclusive  power  and  authority  to
administer  this  Agreement  and to exercise all rights and powers  specifically
granted to the Board, or the Company, or as may be necessary or advisable in the



administration of this Agreement,  including,  without limitation, the right and
power to (i)  interpret  the  provisions  of this  Agreement  and (ii)  make all
determinations  deemed  necessary or advisable  for the  administration  of this
Agreement  (including a  determination  to redeem or not redeem the Rights or to
amend  the  Agreement).  All such  actions,  calculations,  interpretations  and
determinations  (including, for purposes of clause (y) below, all omissions with
respect to the  foregoing)  which are done or made by the Board of  Directors in
good  faith,  shall (x) be final,  conclusive  and binding on the  Company,  the
Rights Agent,  the holders of the Rights  Certificates and all other parties and
(y) not subject the Board of  Directors  to any  liability to the holders of the
Rights. All determinations and actions requiring the vote of, or permitted to be
taken by, the Board of Directors shall be by the affirmative  vote of a majority
of such Board of Directors to be valid and binding.

Section  30  Benefits  of this  Agreement.

     Nothing in this  Agreement  shall be  construed to give to any Person other
than the  Company,  the Rights  Agent and the  registered  holders of the Rights
Certificates  (and, prior to the Distribution Date, the Common Shares) any legal
or equitable  right,  remedy or claim under this  Agreement;  but this Agreement
shall be for the sole and exclusive benefit of the Company, the Rights Agent and
the  registered   holders  of  the  Rights   Certificates  (and,  prior  to  the
Distribution Date, the Common Shares).

Section 31 Severability.

     If any term,  provision,  covenant or restriction of this Agreement is held
by a court of competent  jurisdiction or other authority to be invalid,  void or
unenforceable,   the   remainder  of  the  terms,   provisions,   covenants  and
restrictions  of this Agreement  shall remain in full force and effect and shall
in no  way  be  affected,  impaired  or  invalidated;  provided,  however,  that
notwithstanding  anything in this  Agreement to the contrary,  if any such term,
provision,  covenant or  restriction  is held by such court or  authority  to be
invalid, void or unenforceable and the Board of Directors determines in its good
faith  judgment that severing the invalid  language  from this  Agreement  would
adversely  affect  the  purpose  or  effect  of this  Agreement,  the  right  of
redemption  set forth in Section  23 hereof  shall be  reinstated  and shall not
expire until the Close of Business on the tenth day  following  the date of such
determination by the Board of Directors.

Section  32  Governing  Law.

     This Agreement and each Right and each Rights  Certificate issued hereunder
shall be deemed to be a contract  made  under the laws of the State of  Delaware
and for all purposes  shall be governed by and construed in accordance  with the
laws of such State  applicable  to contracts to be made and  performed  entirely
within such State.

Section  33  Counterparts.

     This  Agreement may be executed in any number of  counterparts  and each of
such  counterparts  shall for all purposes be deemed to be an original,  and all
such counterparts shall together constitute but one and the same instrument.

Section 34 Descriptive Headings.

     Descriptive headings of the several Sections of this Agreement are inserted
for convenience only and shall not control or affect the meaning or construction
of any of the provisions hereof.





     IN WITNESS  WHEREOF,  the parties  hereto have caused this  Agreement to be
duly executed as of the day and year first above written.

                                  "COMPANY"
                                  NEUROCRINE BIOSCIENCES, INC.



                                  By:
                                     --------------------------------------
                                  Name:      Gary Lyons
                                  Title:     CEO


                                  "RIGHTS AGENT"
                                  AMERICAN STOCK TRANSFER & TRUST COMPANY



                                  By:
                                     --------------------------------------
                                  Name:
                                  Title:     Vice President





                                       A-5


                                    EXHIBIT A

   CERTIFICATE OF DESIGNATIONS OF RIGHTS, PREFERENCES AND PRIVILEGES OF SERIES
         A PARTICIPATING PREFERRED STOCK OF NEUROCRINE BIOSCIENCES, INC.

     The  undersigned,  Gary  A.  Lyons  and  Margaret-Valeur-Jensen  do  hereby
certify:

     1. That they are the duly  elected  and  acting  President  and  Secretary,
respectively,  of  Neurocrine  Biosciences,  Inc., a Delaware  corporation  (the
"CORPORATION").

     2. That pursuant to the authority  conferred upon the Board of Directors by
the  Certificate of  Incorporation  of the said  Corporation,  the said Board of
Directors on April 10, 1997 adopted the following  resolution  creating a series
of 50,000  shares  of  Preferred  Stock  designated  as  Series A  Participating
Preferred Stock:

     "RESOLVED,  that pursuant to the authority vested in the Board of Directors
of the corporation by the Restated  Certificate of  Incorporation,  the Board of
Directors  does hereby  provide for the issue of a series of Preferred  Stock of
the   Corporation  and  does  hereby  fix  and  herein  state  and  express  the
designations,  powers, preferences and relative and other special rights and the
qualifications,  limitations and  restrictions of such series of Preferred Stock
as follows:

Section 1. Designation and Amount.

     The shares of such series shall be  designated  as "SERIES A  PARTICIPATING
PREFERRED  STOCK." The Series A  Participating  Preferred Stock shall have a par
value of $0.001 per share,  and the number of shares  constituting  such  series
shall be 50,000.

Section 2. Proportional Adjustment.

     In the event the  Corporation  shall at any time after the  issuance of any
share or shares of  Series A  Participating  Preferred  Stock  (i)  declare  any
dividend on Common Stock of the Corporation  ("COMMON  STOCK") payable in shares
of Common Stock,  (ii) subdivide the  outstanding  Common Stock or (iii) combine
the outstanding Common Stock into a smaller number of shares,  then in each such
case the Corporation shall  simultaneously  effect a proportional  adjustment to
the number of outstanding shares of Series A Participating Preferred Stock.

Section 3. Dividends and Distributions.

(a)  Subject to the prior and superior right of the holders of any shares of any
     series of  Preferred  Stock  ranking  prior and  superior  to the shares of
     Series A  Participating  Preferred  Stock with  respect to  dividends,  the
     holders  of shares  of  Series A  Participating  Preferred  Stock  shall be
     entitled to receive  when, as and if declared by the Board of Directors out
     of funds legally available for the purpose,  quarterly dividends payable in
     cash on the last day of January, April, July and October in each year (each
     such date being referred to herein as a "QUARTERLY DIVIDEND PAYMENT DATE"),
     commencing  on the first  Quarterly  Dividend  Payment Date after the first
     issuance  of a share  or  fraction  of a share of  Series  A  Participating



     Preferred Stock, in an amount per share (rounded to the nearest cent) equal
     to 1,000 times the  aggregate per share amount of all cash  dividends,  and
     1,000  times  the  aggregate  per  share  amount  (payable  in kind) of all
     non-cash dividends or other  distributions other than a dividend payable in
     shares of Common Stock or a subdivision of the outstanding shares of Common
     Stock (by  reclassification  or  otherwise),  declared on the Common  Stock
     since the immediately  preceding  Quarterly Dividend Payment Date, or, with
     respect  to the first  Quarterly  Dividend  Payment  Date,  since the first
     issuance  of any share or  fraction  of a share of  Series A  Participating
     Preferred Stock.

(b)  The  Corporation  shall declare a dividend or  distribution on the Series A
     Participating   Preferred   Stock  as  provided  in  paragraph   (a)  above
     immediately  after it  declares a dividend  or  distribution  on the Common
     Stock (other than a dividend payable in shares of Common Stock).

(c)  Dividends  shall  begin  to  accrue  on  outstanding  shares  of  Series  A
     Participating Preferred Stock from the Quarterly Dividend Payment Date next
     preceding  the date of  issue  of such  shares  of  Series A  Participating
     Preferred  Stock,  unless the date of issue of such  shares is prior to the
     record date for the first  Quarterly  Dividend  Payment Date, in which case
     dividends  on such  shares  shall begin to accrue from the date of issue of
     such shares,  or unless the date of issue is a Quarterly  Dividend  Payment
     Date or is a date after the record date for the determination of holders of
     shares of Series A  Participating  Preferred  Stock  entitled  to receive a
     quarterly  dividend and before such  Quarterly  Dividend  Payment  Date, in
     either of which  events  such  dividends  shall  begin to accrue  from such
     Quarterly  Dividend  Payment Date.  Accrued but unpaid  dividends shall not
     bear  interest.  Dividends  paid on the  shares of  Series A  Participating
     Preferred  Stock in an amount less than the total amount of such  dividends
     at the time accrued and payable on such shares shall be allocated  pro rata
     on a  share-by-share  basis among all such shares at the time  outstanding.
     The  Board of  Directors  may fix a record  date for the  determination  of
     holders of shares of Series A  Participating  Preferred  Stock  entitled to
     receive  payment of a dividend  or  distribution  declared  thereon,  which
     record  date  shall be no more than 30 days prior to the date fixed for the
     payment thereof.

Section 4. Voting Rights.

     The holders of shares of Series A Participating  Preferred Stock shall have
the following voting rights:

(a)  Each share of Series A  Participating  Preferred  Stock  shall  entitle the
     holder  thereof to 1,000  votes on all matters  submitted  to a vote of the
     stockholders of the Corporation.

(b)  Except as  otherwise  provided  herein or by law,  the holders of shares of
     Series A Participating  Preferred Stock and the holders of shares of Common
     Stock shall vote  together as one class on all matters  submitted to a vote
     of stockholders of the Corporation.

(c)  Except as  required  by law,  holders of Series A  Participating  Preferred
     Stock shall have no special  voting  rights and their  consent shall not be
     required  (except to the extent they are  entitled to vote with  holders of
     Common Stock as set forth herein) for taking any corporate action.


Section 5. Certain Restrictions.

(a)  The  Corporation  shall not declare any dividend on, make any  distribution
     on, or redeem or purchase or otherwise acquire for consideration any shares
     of Common Stock after the first  issuance of a share or fraction of a share
     of Series A Participating  Preferred Stock unless concurrently therewith it
     shall declare a dividend on the Series A  Participating  Preferred Stock as
     required by Section 3 hereof.

(b)  Whenever quarterly dividends or other dividends or distributions payable on
     the Series A Participating  Preferred Stock as provided in Section 3 are in
     arrears,  thereafter  and  until  all  accrued  and  unpaid  dividends  and
     distributions, whether or not declared, on shares of Series A Participating
     Preferred Stock  outstanding  shall have been paid in full, the Corporation
     shall not

     (i)  declare  or pay  dividends  on,  make any other  distributions  on, or
          redeem or purchase or otherwise  acquire for  consideration any shares
          of stock ranking junior  (either as to dividends or upon  liquidation,
          dissolution  or winding  up) to the Series A  Participating  Preferred
          Stock;

     (ii) declare  or pay  dividends  on,  make any other  distributions  on any
          shares of stock  ranking on a parity  (either as to  dividends or upon
          liquidation,  dissolution  or winding up) with Series A  Participating
          Preferred  Stock,  except  dividends  paid  ratably  on the  Series  A
          Participating  Preferred  Stock  and all  such  parity  stock on which
          dividends are payable or in arrears in proportion to the total amounts
          to which the holders of all such shares are then entitled;

     (iii)redeem or purchase or otherwise  acquire for  consideration  shares of
          any  stock  ranking  on a  parity  (either  as to  dividends  or  upon
          liquidation,   dissolution   or   winding   up)  with  the   Series  A
          Participating  Preferred  Stock,  provided that the Corporation may at
          any time  redeem,  purchase or  otherwise  acquire  shares of any such
          parity  stock in exchange  for shares of any stock of the  Corporation
          ranking   junior   (either  as  to  dividends  or  upon   dissolution,
          liquidation  or winding  up) to the Series A  Participating  Preferred
          Stock;

     (iv) purchase or otherwise acquire for consideration any shares of Series A
          Participating  Preferred  Stock,  or any shares of stock  ranking on a
          parity  with the Series A  Participating  Preferred  Stock,  except in
          accordance with a purchase offer made in writing or by publication (as
          determined  by the Board of  Directors)  to all holders of such shares
          upon such terms as the Board of Directors,  after consideration of the
          respective  annual  dividend  rates  and  other  relative  rights  and
          preferences of the respective  series and classes,  shall determine in
          good  faith  will  result in fair and  equitable  treatment  among the
          respective series or classes.

(c)  The  Corporation  shall not permit any  subsidiary  of the  Corporation  to
     purchase or otherwise  acquire for consideration any shares of stock of the
     Corporation  unless the  Corporation  could,  under  paragraph  (a) of this
     Section 5,  purchase or  otherwise  acquire such shares at such time and in
     such manner.


Section 6. Reacquired Shares.

     Any shares of Series A Participating Preferred Stock purchased or otherwise
acquired  by the  Corporation  in any manner  whatsoever  shall be  retired  and
canceled  promptly  after the  acquisition  thereof.  All such shares shall upon
their cancellation  become authorized but unissued shares of Preferred Stock and
may be  reissued  as part of a new  series of  Preferred  Stock to be created by
resolution or resolutions  of the Board of Directors,  subject to the conditions
and  restrictions on issuance set forth herein and, in the Restated  Certificate
of Incorporation, as then amended.

Section 7. Liquidation, Dissolution or Winding Up.

     Upon any  liquidation,  dissolution or winding up of the  Corporation,  the
holders of shares of Series A Participating Preferred Stock shall be entitled to
receive an aggregate  amount per share equal to 1000 times the aggregate  amount
to be distributed  per share to holders of shares of Common Stock plus an amount
equal  to  any  accrued  and  unpaid  dividends  on  such  shares  of  Series  A
Participating Preferred Stock.

Section 8. Consolidation, Merger, etc.

     In case  the  Corporation  shall  enter  into  any  consolidation,  merger,
combination  or other  transaction  in which  the  shares  of  Common  Stock are
exchanged for or changed into other stock or  securities,  cash and/or any other
property,  then in any such case the shares of Series A Participating  Preferred
Stock shall at the same time be similarly  exchanged or changed in an amount per
share  equal to 1,000  times the  aggregate  amount of stock,  securities,  cash
and/or any other property  (payable in kind),  as the case may be, into which or
for which each share of Common Stock is changed or exchanged.

Section 9. No Redemption.

     The  shares  of  Series  A  Participating  Preferred  Stock  shall  not  be
redeemable.

Section 10. Ranking.

     The Series A  Participating  Preferred Stock shall rank junior to all other
series of the  Corporation's  Preferred Stock as to the payment of dividends and
the  distribution  of assets,  unless the terms of any such series shall provide
otherwise.

Section 11. Amendment.

     The Restated  Certificate of Incorporation of the Corporation  shall not be
further amended in any manner which would materially alter or change the powers,
preference or special rights of the Series A Participating Preferred Stock so as
to affect  them  adversely  without  the  affirmative  vote of the  holders of a
majority of the outstanding  shares of Series A Participating  Preferred  Stock,
voting separately as a class.

Section 12. Fractional Shares.

     Series A  Participating  Preferred  Stock may be issued in  fractions  of a
share which shall entitle the holder, in proportion to such holder's  fractional
shares,   to  exercise  voting  rights,   receive   dividends,   participate  in
distributions and to have the benefit of all other rights of holders of Series A
Participating Preferred Stock.

     RESOLVED  FURTHER,  that  the  President  or any  Vice  President  and  the
Secretary or any  Assistant  Secretary of this  corporation  be, and they hereby
are, authorized and directed to prepare and file a Certificate of Designation of
Rights,  Preferences and Privileges in accordance with the foregoing  resolution
and the  provisions  of Delaware  law and to take such  actions as they may deem
necessary or appropriate to carry out the intent of the foregoing resolution."


     We further  declare  under penalty of perjury that the matters set forth in
the  foregoing  Certificate  of  Designation  are  true and  correct  of our own
knowledge.

                  Executed at _______________ on ________________, 20.




                        /s/ Gary A. Lyons
                        --------------------------------------------
                        Gary A. Lyons, President


                        /s/ Margaret Valeur-Jensen
                        --------------------------------------------
                        Margaret Valeur-Jensen, Secretary





                                       B-3

                                    EXHIBIT B

                           FORM OF RIGHTS CERTIFICATE

Certificate No. R -                           Series A Preferred Purchase Rights

         NOT  EXERCISABLE  AFTER THE EARLIER OF (i) APRIL 10, 2007 (ii) THE DATE
         TERMINATED  BY THE COMPANY OR (iii) THE DATE THE COMPANY  EXCHANGES THE
         RIGHTS  PURSUANT  TO THE RIGHTS  AGREEMENT.  THE RIGHTS ARE  SUBJECT TO
         REDEMPTION,  AT THE  OPTION OF THE  COMPANY,  AT $0.01 PER RIGHT ON THE
         TERMS SET FORTH IN THE RIGHTS AGREEMENT.  UNDER CERTAIN  CIRCUMSTANCES,
         RIGHTS  BENEFICIALLY  OWNED BY AN  ACQUIRING  PERSON OR AN AFFILIATE OR
         ASSOCIATE  OF AN  ACQUIRING  PERSON (AS SUCH  TERMS ARE  DEFINED IN THE
         RIGHTS  AGREEMENT) AND ANY SUBSEQUENT  HOLDER OF SUCH RIGHTS MAY BECOME
         NULL AND VOID. [THE RIGHTS  REPRESENTED BY THIS RIGHTS  CERTIFICATE ARE
         OR WERE  BENEFICIALLY  OWNED BY A PERSON WHO WAS OR BECAME AN ACQUIRING
         PERSON OR AN AFFILIATE  OR  ASSOCIATE  OF AN ACQUIRING  PERSON (AS SUCH
         TERMS ARE DEFINED IN THE RIGHTS  AGREEMENT).  ACCORDINGLY,  THIS RIGHTS
         CERTIFICATE AND THE RIGHTS  REPRESENTED HEREBY MAY BECOME NULL AND VOID
         IN  THE  CIRCUMSTANCES   SPECIFIED  IN  SECTION  7(e)  OF  SUCH  RIGHTS
         AGREEMENT.]1

                               RIGHTS CERTIFICATE

                          NEUROCRINE BIOSCIENCES, INC.

     This certifies that ______________________________,  or registered assigns,
is the registered  owner of the number of Rights set forth above,  each of which
entitles the owner thereof,  subject to the terms,  provisions and conditions of
the Amended and Restated  Rights  Agreement  dated as of January 11, 2002,  (the
"RIGHTS  AGREEMENT"),  by and between NEUROCRINE  BIOSCIENCES,  INC., a Delaware
corporation (the  "COMPANY"),  and American Stock Transfer & Trust Company ( the
"RIGHTS AGENT"), to purchase from the Company at any time after the Distribution
Date (as such term is defined in the Rights  Agreement)  and prior to 5:00 P.M.,
New York time,  on April 10, 2007 at the office of the Rights  Agent  designated
for such  purpose,  or at the  office  of its  successor  as Rights  Agent,  one
one-thousandth  (1/1,000)  of a fully  paid  non-assessable  share  of  Series A
Participating  Preferred Stock, no par value, (the "PREFERRED  SHARES"),  of the

_________________
1    The portion of the legend in bracket  shall be inserted  only if applicable
     and shall replace the preceding sentence.




Company,  at a Exercise Price of $350.00 per one thousandth of a Preferred Share
(the  "EXERCISE  PRICE"),   upon  presentation  and  surrender  of  this  Rights
Certificate  with the Form of Election to Purchase and related  Certificate duly
executed.  The number of Rights  evidenced by this Rights  Certificate  (and the
number of  one-thousandths  of a  Preferred  Share which may be  purchased  upon
exercise hereof) set forth above are the number and Exercise Price as of January
11, 2002 based on the Preferred  Shares as constituted at such date. As provided
in the Rights Agreement, the Exercise Price and the number and kind of Preferred
Shares or other  securities  which may be  purchased  upon the  exercise  of the
Rights  evidenced by this Rights  Certificate  are subject to  modification  and
adjustment upon the happening of certain events.

     This  Rights  Certificate  is subject to all of the terms,  provisions  and
conditions of the Rights Agreement,  which terms,  provisions and conditions are
hereby  incorporated  herein by  reference  and made a part  hereof and to which
Rights Agreement  reference is hereby made for a full description of the rights,
limitations  of rights,  obligations,  duties and  immunities  hereunder  of the
Rights  Agent,  the Company and the  holders of the Rights  Certificates,  which
limitations of rights include the temporary  suspension of the exercisability of
such Rights under the specific  circumstances set forth in the Rights Agreement.
Copies of the Rights Agreement are on file at the principal executive offices of
the Company and the above-mentioned office of the Rights Agent.

     Subject to the provisions of the Rights Agreement,  the Rights evidenced by
this Rights Certificate (i) may be redeemed by the Company,  at its option, at a
redemption  price of $0.01 per Right or (ii) may be  exchanged by the Company in
whole or in part for Common  Shares,  substantially  equivalent  rights or other
consideration as determined by the Company.

     This Rights Certificate,  with or without other Rights  Certificates,  upon
surrender at the office of the Rights Agent designated for such purpose,  may be
exchanged for another Rights  Certificate or Rights  Certificates  of like tenor
and date  evidencing  Rights  entitling the holder to purchase a like  aggregate
amount of securities as the Rights evidenced by the Rights Certificate or Rights
Certificates  surrendered  shall have entitled such holder to purchase.  If this
Rights  Certificate  shall be exercised in part, the holder shall be entitled to
receive upon surrender hereof another Rights Certificate or Rights  Certificates
for the number of whole Rights not exercised.

     No fractional  portion of less than one one-thousandth of a Preferred Share
will be issued upon the exercise of any Right or Rights  evidenced hereby but in
lieu thereof a cash payment will be made, as provided in the Rights Agreement.

     No holder of this Rights Certificate, as such, shall be entitled to vote or
receive  dividends  or be deemed for any  purpose  the  holder of the  Preferred
Shares  or of any  other  securities  of the  Company  which  may at any time be
issuable on the  exercise  hereof,  nor shall  anything  contained in the Rights
Agreement or herein be construed to confer upon the holder hereof,  as such, any
of the  rights  of a  stockholder  of the  Company  or any right to vote for the
election  of  directors  or upon any matter  submitted  to  stockholders  at any
meeting thereof,  or to give or withhold consent to any corporate  action, or to
receive notice of meetings or other actions  affecting  stockholders  (except as
provided  in the Rights  Agreement),  or to receive  dividends  or  subscription
rights,  or  otherwise,  until  the  Right or Rights  evidenced  by this  Rights
Certificate shall have been exercised as provided in the Rights Agreement.

     This Rights  Certificate  shall not be valid or obligatory  for any purpose
until it shall have been countersigned by the Rights Agent.



     WITNESS the facsimile  signature of the proper  officers of the Company and
its corporate seal. Dated as of _______________, 20____.

                       ATTEST:
                       NEUROCRINE BIOSCIENCES, INC.

                       ___________________________________
                       By:  Margaret Valeur-Jensen
                       Its: Secretary


                       Countersigned:

                       AMERICAN STOCK TRANSFER & TRUST COMPANY,
                       as Rights Agent

                       By:   ______________________________
                       Its:  ______________________________







                   FORM OF REVERSE SIDE OF RIGHTS CERTIFICATE

                               FORM OF ASSIGNMENT

                (To be executed by the registered holder if such
               holder desires to transfer the Rights Certificate)

     FOR VALUE RECEIVED  ___________________________  hereby sells,  assigns and
transfers unto  _________________________________________________  (Please print
name and address of transferee)  __________________________________  this Rights
Certificate,  together  with all right,  title and  interest  therein,  and does
hereby irrevocably constitute and appoint  __________________________  Attorney,
to  transfer  the within  Rights  Certificate  on the books of the  within-named
Company, with full power of substitution.

Dated: _______________, 20____



                                             _________________________________
                                             Signature

Signature Guaranteed:

                  Signatures must be guaranteed by a member firm of a registered
national securities exchange, a member of the National Association of Securities
Dealers,  Inc.,  or a  commercial  bank or trust  company  having  an  office or
correspondent in the United States.






                                   CERTIFICATE

    The undersigned hereby certifies by checking the appropriate boxes that:

     (1) this  Rights  Certificate  [ ] is [ ] is not being sold,  assigned  and
transferred by or on behalf of a Person who is or was an Acquiring Person, or an
Affiliate  or  Associate  of any such  Person (as such terms are  defined in the
Rights Agreement);

     (2) after due inquiry and to the best knowledge of the undersigned,  it [ ]
did [ ] did not acquire the Rights evidenced by this Rights Certificate from any
Person who is, was or subsequently became an Acquiring Person or an Affiliate or
Associate of any such Person.

Dated: _______________, 20____



                                             __________________________________
                                             Signature

Signature Guaranteed:

                  Signatures must be guaranteed by a member firm of a registered
national securities exchange, a member of the National Association of Securities
Dealers,  Inc.,  or a  commercial  bank or trust  company  having  an  office or
correspondent in the United States.





             FORM OF REVERSE SIDE OF RIGHTS CERTIFICATE - CONTINUED
                          FORM OF ELECTION TO PURCHASE

                      (To be executed if holder desires to
                        exercise the Rights Certificate)

To: ___________________________

     The     undersigned     hereby     irrevocably     elects    to    exercise
_________________________  Rights  represented  by this  Rights  Certificate  to
purchase the number of  one-thousandths  of a Preferred  Share issuable upon the
exercise of such Rights and requests that  certificates  for such number of one-
thousandths of a Preferred Share issued in the name of:

Please insert social security
or other identifying number

________________________________________________________________________________
                         (Please print name and address)

________________________________________________________________________________

If such number of Rights  shall not be all the Rights  evidenced  by this Rights
Certificate,  a new Rights  Certificate for the balance remaining of such Rights
shall be registered in the name of and delivered to:

Please insert social security
or other identifying number

________________________________________________________________________________
                         (Please print name and address)

________________________________________________________________________________


Dated: _______________, 20____


                                    ___________________________________________
                                    Signature

Signature Guaranteed:

                  Signatures must be guaranteed by a member firm of a registered
national securities exchange, a member of the National Association of Securities
Dealers,  Inc.,  or a  commercial  bank or trust  company  having  an  office or
correspondent in the United States.





                                   CERTIFICATE

    The undersigned hereby certifies by checking the appropriate boxes that:

     (1) the Rights  evidenced  by this Rights  Certificate  [ ] are [ ] are not
being exercised by or on behalf of a Person who is or was an Acquiring Person or
an  Affiliate  or Associate of any such Person (as such terms are defined in the
Rights Agreement);

     (2) after due inquiry and to the best knowledge of the undersigned,  it [ ]
did [ ] did not acquire the Rights evidenced by this Rights Certificate from any
Person who is, was or subsequently became an Acquiring Person or an Affiliate or
Associate of any such Person.

Dated: _______________, 20____


                                                  _____________________________
                                                  Signature

Signature Guaranteed:

     Signatures  must be  guaranteed  by a member firm of a registered  national
securities exchange, a member of the National Association of Securities Dealers,
Inc., or a commercial bank or trust company having an office or correspondent in
the United States.





                  FORM OF REVERSE SIDE OF RIGHTS CERTIFICATE -
                                CONTINUED NOTICE

     The  signature in the  foregoing  Forms of  Assignment  and  Election  must
conform to the name as written upon the face of this Rights Certificate in every
particular, without alteration or enlargement or any change whatsoever.





                                       C-2


                                    EXHIBIT C

                             STOCKHOLDER RIGHTS PLAN
                          NEUROCRINE BIOSCIENCES, INC.

SUMMARY OF RIGHTS1

     Distribution and Transfer of Rights:  The Board of Directors has declared a
Transfer of Rights dividend of one Right for Rights  Certificate:  each share of
NEUROCRINE BIOSCIENCES, INC. Common Stock outstanding. Prior to the Distribution
Date  referred  to below,  the Rights  will be  evidenced  by and trade with the
certificates  for the Common  Stock.  After the  Distribution  Date,  NEUROCRINE
BIOSCIENCES, INC. (the "COMPANY") will mail Rights certificates to the Company's
stockholders  and the  Rights  will  become  transferable  apart from the Common
Stock.

     Distribution  Date:  Rights will  separate from the Common Stock and become
exercisable following (a) the tenth day (or such later date as may be determined
by a  majority  of the  Board of  Directors)  after a person  or group  acquires
beneficial  ownership  of 15% or more of the  Company's  Common Stock or (b) the
tenth  business  day (or such  later date as may be  determined  by the Board of
Directors)  after a person or group  announces a tender or exchange  offer,  the
consummation  of which would  result in ownership by a person or group of 15% or
more of the Company's Common Stock.

     Preferred Stock Purchasable Upon Exercise of Rights: After the Distribution
Date,  each Right will entitle the holder to purchase for $350.00 (the "EXERCISE
PRICE"),  a fraction of a share of the Company's  Preferred  Stock with economic
terms similar to that of one share of the Company's Common Stock.

     Flip-In:  If an acquiror (an "ACQUIRING PERSON") obtains 15% or more of the
Company's  Common Stock (other than  pursuant to a tender offer deemed  adequate
and in the best  interests of the Company and its  stockholders  by the Board of
Directors (a "PERMITTED OFFER")), then each Right (other than Rights owned by an
Acquiring Person or its affiliates) will entitle the holder thereof to purchase,
for the Exercise Price, a number of shares of the Company's  Common Stock having
a then current market value of twice the Exercise Price.

     Flip-Over:  If,  after  an  Acquiring  Person  obtains  15% or  more of the
Company's  Common  Stock,  (a) the Company  merges into another  entity,  (b) an
acquiring  entity merges into the Company or (c) the Company sells more than 50%
of the  Company's  assets or earning  power,  then each Right (other than Rights
owned by an Acquiring  Person or its affiliates) will entitle the holder thereof
to purchase,  for the Exercise  Price, a number of shares of Common Stock of the
person engaging in the  transaction  having a then current market value of twice
the Exercise Price (unless the transaction  satisfies certain  conditions and is
consummated  with a person who acquired shares pursuant to a Permitted Offer, in
which case the Rights will expire).



     Exchange Provision:  At any time after the date an Acquiring Person obtains
15% or more of the Company's  Common Stock and prior to the  acquisition  by the
Acquiring Person of 50% of the outstanding Common Stock, a majority of the Board
of Directors  may exchange the Rights  (other than Rights owned by the Acquiring
Person or its  affiliates),  in whole or in part,  for shares of Common Stock of
the Company at an exchange ratio of one share of Common Stock per Right (subject
to adjustment).

     Redemption of Rights: Rights will be redeemable at the Company's option for
$0.01 per Right at any time  prior to a public  announcement  that a Person  has
acquired beneficial  ownership of 15% or more of the Company's Common Stock (the
"SHARES ACQUISITION DATE").

     Expiration  of the  Rights:  The Rights  expire on the  earliest of (a) ten
years after the date of adoption of the Plan,  (b) exchange or redemption of the
Rights as described  above, or (c)  consummation of a merger,  consolidation  or
asset sale resulting in expiration of the Rights as described above.

     Amendment of Rights:  The terms of the Rights and the Rights  Agreement may
be amended in any respect  without the consent of the Rights holders on or prior
to the  Distribution  Date;  thereafter,  the terms of the Rights and the Rights
Agreement may be amended  without the consent of the Rights  holders in order to
cure any  ambiguities  or to make  changes  which do not  adversely  affect  the
interests of Rights holders (other than the Acquiring Person).

     Voting Rights: Rights will not have any voting rights.


     Anti-Dilution Provisions: Rights will have the benefit of certain customary
anti-dilution provisions.

     Taxes: The Rights distribution should not be taxable for federal income tax
purposes.  However,  following an event which renders the Rights  exercisable or
upon redemption of the Rights, stockholders may recognize taxable income.

     The foregoing is a summary of certain  principal terms of the Plan only and
is qualified in its entirety by reference to the detailed terms of the Preferred
Shares Rights Agreement between the Company and the Rights Agent.
_________________
1    The portion of the legend in bracket  shall be inserted  only if applicable
     and shall replace the preceding sentence.

                                        1

FOR IMMEDIATE RELEASE

Contact at Neurocrine Biosciences
Claudia Jones or Paul Hawran  (858) 658-7600



              NEUROCRINE BIOSCIENCES AMENDS SHAREHOLDER RIGHTS PLAN

San Diego, CA, January 11, 2002 - Neurocrine  Biosciences,  Inc. (NASDAQ:  NBIX)
today  announced  that its Board of  Directors  has approved an amendment of its
shareholder  rights plan to increase  the initial  exercise  price of the rights
issued pursuant to the plan from $51.75 to $350.00 per right.

The intent of the increase is to preserve the  effectiveness of the plan in view
of the recent  appreciation of the company's  stock price.  No other  amendments
were made to the plan. The  shareholder  rights plan was originally  approved in
April 1997. The Company was advised by Robertson Stephens, Inc.

Neurocrine  Biosciences,  Inc.  is  a  product-based  biopharmaceutical  company
focused on  neurological  and  endocrine  diseases  and  disorders.  Our product
candidates  address  some of the  largest  pharmaceutical  markets  in the world
including insomnia, anxiety,  depression,  malignant brain tumors and peripheral
cancers,  diabetes,   multiple  sclerosis,   irritable  bowel  syndrome,  eating
disorders,  pain,  stroke,  and  certain  female  health  disorders.  Neurocrine
Biosciences,  Inc. news releases are available through the Company's website via
the Internet at http://www.neurocrine.com.

                           -------------------------

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